Body Mass Index and Risk of Parkinson's Disease: A Prospective Cohort Study
High body mass index has been associated with increased risk of several chronic diseases, including cardiovascular disease, and, recently, Alzheimer's disease. There are few data on the association of body mass index with Parkinson's disease, and results have been inconsistent. The authors...
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| Veröffentlicht in: | American journal of epidemiology 2007-11, Vol.166 (10), p.1186-1190 |
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| container_title | American journal of epidemiology |
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| creator | Logroscino, Giancarlo Sesso, Howard D. Paffenbarger, Ralph S. Lee, I-Min |
| description | High body mass index has been associated with increased risk of several chronic diseases, including cardiovascular disease, and, recently, Alzheimer's disease. There are few data on the association of body mass index with Parkinson's disease, and results have been inconsistent. The authors conducted a prospective study among 10,812 men in the Harvard Alumni Health Study, followed from 1988 to 1998 (mean age at baseline: 67.7 years), to test the hypothesis that body mass index is associated with Parkinson's disease risk. Among 106 incident cases of Parkinson's disease, body mass index at baseline was not associated with Parkinson's disease risk (for body mass index |
| doi_str_mv | 10.1093/aje/kwm211 |
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There are few data on the association of body mass index with Parkinson's disease, and results have been inconsistent. The authors conducted a prospective study among 10,812 men in the Harvard Alumni Health Study, followed from 1988 to 1998 (mean age at baseline: 67.7 years), to test the hypothesis that body mass index is associated with Parkinson's disease risk. Among 106 incident cases of Parkinson's disease, body mass index at baseline was not associated with Parkinson's disease risk (for body mass index <22.5, 22.5–<24.9, and ≥25.0 kg/m2: multivariate relative risks = 1.51 (95% confidence interval: 0.95, 2.40), 1.00 (referent), and 0.86 (95% confidence interval: 0.53, 1.41)). The authors had information on body mass index during late adolescence, when men entered college; this was unrelated to Parkinson's disease risk as well. Subjects who lost at least 0.5 units of body mass index per decade between college entry and 1988 had a significantly increased Parkinson's disease risk, compared with men having stable body mass index (multivariate relative risk = 2.60, 95% confidence interval: 1.10, 6.10). The authors conclude that body mass index is unrelated to Parkinson's disease risk and speculate that the observation of increased risk with body mass index loss since late adolescence may reflect weight loss due to Parkinson's disease that preceded clinical diagnosis.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwm211</identifier><identifier>PMID: 17709328</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Adult ; Age Factors ; Aged ; Analysis. Health state ; Biological and medical sciences ; Body fat ; Body Mass Index ; body weight ; cohort studies ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Epidemiology ; General aspects ; Humans ; Male ; Medical research ; Medical sciences ; Middle Aged ; Miscellaneous ; Neurology ; Obesity ; Parkinson disease ; Parkinson Disease - epidemiology ; Parkinson's disease ; Prospective Studies ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Assessment ; Risk factors ; United States - epidemiology</subject><ispartof>American journal of epidemiology, 2007-11, Vol.166 (10), p.1186-1190</ispartof><rights>American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2007</rights><rights>2008 INIST-CNRS</rights><rights>American Journal of Epidemiology © The Author 2007. Published by the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-a7ef6a5c04f7e0693ea2ee4b5e633010e4914fd9fbfd5bc93428f0f198becf153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19242097$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17709328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Logroscino, Giancarlo</creatorcontrib><creatorcontrib>Sesso, Howard D.</creatorcontrib><creatorcontrib>Paffenbarger, Ralph S.</creatorcontrib><creatorcontrib>Lee, I-Min</creatorcontrib><title>Body Mass Index and Risk of Parkinson's Disease: A Prospective Cohort Study</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>High body mass index has been associated with increased risk of several chronic diseases, including cardiovascular disease, and, recently, Alzheimer's disease. There are few data on the association of body mass index with Parkinson's disease, and results have been inconsistent. The authors conducted a prospective study among 10,812 men in the Harvard Alumni Health Study, followed from 1988 to 1998 (mean age at baseline: 67.7 years), to test the hypothesis that body mass index is associated with Parkinson's disease risk. Among 106 incident cases of Parkinson's disease, body mass index at baseline was not associated with Parkinson's disease risk (for body mass index <22.5, 22.5–<24.9, and ≥25.0 kg/m2: multivariate relative risks = 1.51 (95% confidence interval: 0.95, 2.40), 1.00 (referent), and 0.86 (95% confidence interval: 0.53, 1.41)). The authors had information on body mass index during late adolescence, when men entered college; this was unrelated to Parkinson's disease risk as well. Subjects who lost at least 0.5 units of body mass index per decade between college entry and 1988 had a significantly increased Parkinson's disease risk, compared with men having stable body mass index (multivariate relative risk = 2.60, 95% confidence interval: 1.10, 6.10). The authors conclude that body mass index is unrelated to Parkinson's disease risk and speculate that the observation of increased risk with body mass index loss since late adolescence may reflect weight loss due to Parkinson's disease that preceded clinical diagnosis.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Analysis. Health state</subject><subject>Biological and medical sciences</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>body weight</subject><subject>cohort studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Epidemiology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neurology</subject><subject>Obesity</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinson's disease</subject><subject>Prospective Studies</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>United States - epidemiology</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0V1rFDEUBuAgFrtWb_wBEgQVhLH5zsS7ura2tGr9AulNyGROcPZjsiYztfvvm7KLC17oVW6evIdzXoSeUPKaEsMP3QwO57-XjNJ7aEKFVpViUt1HE0IIqwxTbB89zHlGCKVGkgdon2pdPrJ6gs7fxnaNP7ic8Vnfwg12fYu_dHmOY8CXLs27Psf-Zcbvugwuwxt8hC9TzCvwQ3cNeBp_xjTgr8PYrh-hveAWGR5v3wP0_eT42_S0uvj0_mx6dFF5IehQOQ1BOemJCBqIMhwcAxCNBMU5oQSEoSK0JjShlY03XLA6kEBN3YAPVPID9GKTu0rx1wh5sMsue1gsXA9xzFbVgnMj_w_LNUxNpSrw2V9wFsfUlyUs47IWRrO7tFcb5Mv-OUGwq9QtXVpbSuxdEbYUYTdFFPx0mzg2S2h3dHv5Ap5vgcveLUJyve_yzhkmGDF65-K4-vfAauO6PMDNH1katEpzLe3pjyt7_tHIz0Je2RN-C6i7q1k</recordid><startdate>20071115</startdate><enddate>20071115</enddate><creator>Logroscino, Giancarlo</creator><creator>Sesso, Howard D.</creator><creator>Paffenbarger, Ralph S.</creator><creator>Lee, I-Min</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U1</scope><scope>7X8</scope></search><sort><creationdate>20071115</creationdate><title>Body Mass Index and Risk of Parkinson's Disease: A Prospective Cohort Study</title><author>Logroscino, Giancarlo ; Sesso, Howard D. ; Paffenbarger, Ralph S. ; Lee, I-Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-a7ef6a5c04f7e0693ea2ee4b5e633010e4914fd9fbfd5bc93428f0f198becf153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Analysis. Health state</topic><topic>Biological and medical sciences</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>body weight</topic><topic>cohort studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Epidemiology</topic><topic>General aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Neurology</topic><topic>Obesity</topic><topic>Parkinson disease</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinson's disease</topic><topic>Prospective Studies</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Logroscino, Giancarlo</creatorcontrib><creatorcontrib>Sesso, Howard D.</creatorcontrib><creatorcontrib>Paffenbarger, Ralph S.</creatorcontrib><creatorcontrib>Lee, I-Min</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Risk Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Logroscino, Giancarlo</au><au>Sesso, Howard D.</au><au>Paffenbarger, Ralph S.</au><au>Lee, I-Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body Mass Index and Risk of Parkinson's Disease: A Prospective Cohort Study</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2007-11-15</date><risdate>2007</risdate><volume>166</volume><issue>10</issue><spage>1186</spage><epage>1190</epage><pages>1186-1190</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>High body mass index has been associated with increased risk of several chronic diseases, including cardiovascular disease, and, recently, Alzheimer's disease. There are few data on the association of body mass index with Parkinson's disease, and results have been inconsistent. The authors conducted a prospective study among 10,812 men in the Harvard Alumni Health Study, followed from 1988 to 1998 (mean age at baseline: 67.7 years), to test the hypothesis that body mass index is associated with Parkinson's disease risk. Among 106 incident cases of Parkinson's disease, body mass index at baseline was not associated with Parkinson's disease risk (for body mass index <22.5, 22.5–<24.9, and ≥25.0 kg/m2: multivariate relative risks = 1.51 (95% confidence interval: 0.95, 2.40), 1.00 (referent), and 0.86 (95% confidence interval: 0.53, 1.41)). The authors had information on body mass index during late adolescence, when men entered college; this was unrelated to Parkinson's disease risk as well. Subjects who lost at least 0.5 units of body mass index per decade between college entry and 1988 had a significantly increased Parkinson's disease risk, compared with men having stable body mass index (multivariate relative risk = 2.60, 95% confidence interval: 1.10, 6.10). The authors conclude that body mass index is unrelated to Parkinson's disease risk and speculate that the observation of increased risk with body mass index loss since late adolescence may reflect weight loss due to Parkinson's disease that preceded clinical diagnosis.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>17709328</pmid><doi>10.1093/aje/kwm211</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Age Factors Aged Analysis. Health state Biological and medical sciences Body fat Body Mass Index body weight cohort studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Epidemiology General aspects Humans Male Medical research Medical sciences Middle Aged Miscellaneous Neurology Obesity Parkinson disease Parkinson Disease - epidemiology Parkinson's disease Prospective Studies Public health. Hygiene Public health. Hygiene-occupational medicine Risk Assessment Risk factors United States - epidemiology |
| title | Body Mass Index and Risk of Parkinson's Disease: A Prospective Cohort Study |
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