Plants as a source of anti-cancer agents
Plant-derived compounds have been an important source of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, derived from epipodophyllotoxin, and paclitaxel (taxol ®). A number of promising new agent...
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| Veröffentlicht in: | Journal of ethnopharmacology 2005-08, Vol.100 (1), p.72-79 |
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| container_title | Journal of ethnopharmacology |
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| creator | Cragg, Gordon M. Newman, David J. |
| description | Plant-derived compounds have been an important source of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, derived from epipodophyllotoxin, and paclitaxel (taxol
®). A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest. |
| doi_str_mv | 10.1016/j.jep.2005.05.011 |
| format | Article |
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®). A number of promising new agents are in clinical development based on selective activity against cancer-related molecular targets, including flavopiridol and combretastin A4 phosphate, while some agents which failed in earlier clinical studies are stimulating renewed interest.</description><subject>Animals</subject><subject>anticarcinogenic activity</subject><subject>antineoplastic agents</subject><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Camptothecins</subject><subject>Cell cycle target inhibitors</subject><subject>clinical development</subject><subject>clinical trials</subject><subject>Combretastatins</subject><subject>Flavopiridol</subject><subject>Humans</subject><subject>medicinal plants</subject><subject>Molecular Structure</subject><subject>Neoplasms - drug therapy</subject><subject>phytochemicals</subject><subject>Plants, Medicinal - chemistry</subject><subject>Podophyllotoxins</subject><subject>Taxanes</subject><subject>Vinca alkaloids</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk5_gDfaK_GmNadJ0xSvZPgFAwXddciS05GyrTNpBf-9KR14J7wkcHjOy-Eh5BJoBhTEXZM1uM9ySotsCMARmYIs87QsSnZMppSVMpUlhwk5C6GhlJbA6SmZgKC0KnKYktv3jd51IdExSWh7bzBp6yTOXGr0zqBP9BojcU5Oar0JeHH4Z2T59Pg5f0kXb8-v84dFajjILkVmmbYcLafCcAEr1FW9KqDUldE11QASK47CYsFyZkDYSpYAwhTCFpW0bEZuxt69b796DJ3aumBwE8_Etg9KSM6AxWdGYASNb0PwWKu9d1vtfxRQNehRjYp61KBHDQGIO1eH8n61Rfu3cfARgesRqHWr9Nq7oJYfOQVGY2MFkkXifiQwSvh26FUwDqMo6zyaTtnW_XPALx7JfMI</recordid><startdate>20050822</startdate><enddate>20050822</enddate><creator>Cragg, Gordon M.</creator><creator>Newman, David J.</creator><general>Elsevier Ireland Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050822</creationdate><title>Plants as a source of anti-cancer agents</title><author>Cragg, Gordon M. ; Newman, David J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-e3d3ad4ed406c461bea9fb517a9caf0a118e94e6de5323c16d987116c56d598d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>anticarcinogenic activity</topic><topic>antineoplastic agents</topic><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Camptothecins</topic><topic>Cell cycle target inhibitors</topic><topic>clinical development</topic><topic>clinical trials</topic><topic>Combretastatins</topic><topic>Flavopiridol</topic><topic>Humans</topic><topic>medicinal plants</topic><topic>Molecular Structure</topic><topic>Neoplasms - drug therapy</topic><topic>phytochemicals</topic><topic>Plants, Medicinal - chemistry</topic><topic>Podophyllotoxins</topic><topic>Taxanes</topic><topic>Vinca alkaloids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cragg, Gordon M.</creatorcontrib><creatorcontrib>Newman, David J.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cragg, Gordon M.</au><au>Newman, David J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plants as a source of anti-cancer agents</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2005-08-22</date><risdate>2005</risdate><volume>100</volume><issue>1</issue><spage>72</spage><epage>79</epage><pages>72-79</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Plant-derived compounds have been an important source of several clinically useful anti-cancer agents. These include vinblastine, vincristine, the camptothecin derivatives, topotecan and irinotecan, etoposide, derived from epipodophyllotoxin, and paclitaxel (taxol
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| ispartof | Journal of ethnopharmacology, 2005-08, Vol.100 (1), p.72-79 |
| issn | 0378-8741 1872-7573 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals anticarcinogenic activity antineoplastic agents Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Camptothecins Cell cycle target inhibitors clinical development clinical trials Combretastatins Flavopiridol Humans medicinal plants Molecular Structure Neoplasms - drug therapy phytochemicals Plants, Medicinal - chemistry Podophyllotoxins Taxanes Vinca alkaloids |
| title | Plants as a source of anti-cancer agents |
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