A short-term diabetes induced changes of catecholamines and p38-MAPK in discrete areas of rat brain

Chronic diabetes is associated with the alteration of second messengers and CNS disorders. We have recently identified that protein kinases (CaMKII and PKC-α) and brain neurotransmitters are altered during diabetes as well as in hyperglycemic and acidotic conditions. In this study, we investigated t...

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Veröffentlicht in:	Life sciences (1973) 2005-08, Vol.77 (15), p.1825-1835
Hauptverfasser:	Ramakrishnan, R., Kempuraj, D., Prabhakaran, K., Jayakumar, A.R., Devi, R.S., Suthanthirarajan, N., Namasivayam, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Animals Blood Glucose - metabolism Brain - drug effects Brain - metabolism Catecholamines Catecholamines - metabolism Cerebellum - drug effects Cerebellum - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Diabetes Mellitus, Experimental - metabolism Dopamine - metabolism Epinephrine - metabolism Hippocampus - drug effects Hippocampus - metabolism Hypothalamus - drug effects Hypothalamus - metabolism Insulin - pharmacology Norepinephrine - metabolism p38 Mitogen-Activated Protein Kinases - metabolism p38-MAPK Pons - drug effects Pons - metabolism Rat brain Rats Rats, Wistar
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