Activation of ERK during DNA damage-induced apoptosis involves protein kinase Cdelta

We have previously shown that protein kinase C (PKC) acts upstream of caspases to regulate cisplatin-induced apoptosis. Since extracellular signal-regulated kinases (ERKs) have also been implicated in DNA damage-induced apoptosis, we have examined if ERK signaling pathway acts downstream of PKC in t...

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Veröffentlicht in:	Biochemical and biophysical research communications 2005-09, Vol.334 (4), p.1068-1073
Hauptverfasser:	Basu, Alakananda, Tu, Haidi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cisplatin - pharmacology DNA Damage Enzyme Activation - drug effects Extracellular Signal-Regulated MAP Kinases - metabolism HeLa Cells Humans Protein Kinase C - metabolism Protein Kinase C-delta Signal Transduction - drug effects
Online-Zugang:	Volltext
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