Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer: a case-control study

RNASEL is thought to be a susceptibility gene for hereditary prostate cancer and encodes the endoribonuclease RNase L, which has a role in apoptosis and is a candidate tumour-suppressor protein. A common sequence variation in RNASEL, Arg462Gln, has been associated with hereditary and sporadic prosta...

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Veröffentlicht in:	The lancet oncology 2005-08, Vol.6 (8), p.566-572
Hauptverfasser:	Krüger, Stefan, Silber, Ann-Sophie, Engel, Christoph, Görgens, Heike, Mangold, Elisabeth, Pagenstecher, Constanze, Holinski-Feder, Elke, von Knebel Doeberitz, Magnus, Moeslein, Gabriela, Dietmaier, Wolfgang, Stemmler, Susanne, Friedl, Waltraut, Rüschoff, Josef, Schackert, Hans K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Age of Onset Aged Apoptosis Case-Control Studies Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - pathology Endoribonucleases - genetics Female Gene Dosage Genetic Predisposition to Disease Genetic Variation Genotype & phenotype Germ-Line Mutation Humans Kinases Male Middle Aged Mutation Prostate cancer Prostatic Neoplasms - genetics Signal transduction
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