Runx1/AML1/Cbfa2 Mediates Onset of Mesenchymal Cell Differentiation Toward Chondrogenesis

Runx proteins mediate skeletal development. We studied the regulation of Runx1 during chondrocyte differentiation by real‐time RT‐PCR and its function during chondrogenesis using overexpression and RNA interference. Runx1 induces mesenchymal stem cell commitment to the early stages of chondrogenesis...

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Veröffentlicht in:	Journal of bone and mineral research 2005-09, Vol.20 (9), p.1624-1636
Hauptverfasser:	Wang, YongJun, Belflower, Ruth M, Dong, Yu‐Feng, Schwarz, Edward M, O'Keefe, Regis J, Drissi, Hicham
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcian Blue - pharmacology Animals Biological and medical sciences Blotting, Western Bone and Bones Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins - metabolism Cartilage - cytology Cartilage - metabolism Cell Differentiation Cell Proliferation chondrocytes Chondrocytes - metabolism Collagen Type II - metabolism Collagen Type X - metabolism Coloring Agents - pharmacology Core Binding Factor Alpha 2 Subunit - physiology DNA Primers - chemistry Fundamental and applied biological sciences. Psychology Immunohistochemistry In Situ Hybridization Lac Operon Limb Buds - metabolism Mesoderm - metabolism Mice Mice, Inbred C3H Mice, Inbred ICR Phenotype Protein Isoforms Retroviridae - genetics Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism RNA Interference RNA, Messenger - metabolism RNA, Small Interfering - metabolism Runx1/Cbfa2 Runx2/Cbfa1 skeleton Skeleton and joints Stem Cells - cytology Time Factors transcription Transforming Growth Factor beta - metabolism Up-Regulation Vertebrates: osteoarticular system, musculoskeletal system
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