CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation
Perivascular macrophages (PVM) constitute a subpopulation of resident macrophages in the central nervous system (CNS) that by virtue of their strategic location at the blood‐brain barrier potentially lend themselves to a variety of important functions in both health and disease. Functional evidence...
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| Veröffentlicht in: | Glia 2005-09, Vol.51 (4), p.297-305 |
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| creator | Fabriek, Babs O. Van Haastert, Elise S. Galea, Ian Polfliet, Machteld M.J. Döpp, Ed D. Van Den Heuvel, Michel M. Van Den Berg, Timo K. De Groot, Corline J.A. Van Der Valk, Paul Dijkstra, Christine D. |
| description | Perivascular macrophages (PVM) constitute a subpopulation of resident macrophages in the central nervous system (CNS) that by virtue of their strategic location at the blood‐brain barrier potentially lend themselves to a variety of important functions in both health and disease. Functional evidence suggests that PVM play a supportive role during experimental autoimmune encephalomyelitis in rodents. However, the function of PVM in the human CNS remains poorly characterized. We first set out to investigate the validity of the antibody EDhu1, which recognizes human CD163, to specifically identify human PVM. Second, we wanted to gain insight into the function of PVM in antigen recognition and presentation and therefore we studied the expression of DC‐SIGN, mannose receptor, MHC class II, and several costimulatory molecules by PVM in the normal and inflamed human CNS (multiple sclerosis (MS) brain lesions). Conventional immunohistochemistry and double‐labeled immunofluorescence techniques were used. We show that CD163 specifically reveals PVM in the normal human CNS. In MS lesions, CD163 staining reveals expression on foamy macrophages and microglia, besides an upregulation of the amount of PVM stained. In contrast, mannose receptor expression is restricted to PVM in both normal and inflamed brain tissue. Furthermore, we show that a subpopulation of PVM in the human brain express several molecules involved in antigen recognition, presentation, and costimulation. Therefore PVM, which occupy a strategic location at the BBB, are equipped to recognize antigen and present it to T cells, supporting a role in the regulation of perivascular inflammation in the human CNS. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/glia.20208 |
| format | Article |
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Functional evidence suggests that PVM play a supportive role during experimental autoimmune encephalomyelitis in rodents. However, the function of PVM in the human CNS remains poorly characterized. We first set out to investigate the validity of the antibody EDhu1, which recognizes human CD163, to specifically identify human PVM. Second, we wanted to gain insight into the function of PVM in antigen recognition and presentation and therefore we studied the expression of DC‐SIGN, mannose receptor, MHC class II, and several costimulatory molecules by PVM in the normal and inflamed human CNS (multiple sclerosis (MS) brain lesions). Conventional immunohistochemistry and double‐labeled immunofluorescence techniques were used. We show that CD163 specifically reveals PVM in the normal human CNS. In MS lesions, CD163 staining reveals expression on foamy macrophages and microglia, besides an upregulation of the amount of PVM stained. In contrast, mannose receptor expression is restricted to PVM in both normal and inflamed brain tissue. Furthermore, we show that a subpopulation of PVM in the human brain express several molecules involved in antigen recognition, presentation, and costimulation. Therefore PVM, which occupy a strategic location at the BBB, are equipped to recognize antigen and present it to T cells, supporting a role in the regulation of perivascular inflammation in the human CNS. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0894-1491</identifier><identifier>EISSN: 1098-1136</identifier><identifier>DOI: 10.1002/glia.20208</identifier><identifier>PMID: 15846794</identifier><identifier>CODEN: GLIAEJ</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Antigen Presentation - immunology ; antigen presentation and recognition ; Antigen-Presenting Cells - immunology ; Antigen-Presenting Cells - metabolism ; Antigens, CD - immunology ; Antigens, Differentiation, Myelomonocytic - immunology ; Biological and medical sciences ; Blood-Brain Barrier - cytology ; Blood-Brain Barrier - immunology ; Cell Adhesion Molecules - immunology ; Cell Adhesion Molecules - metabolism ; Central Nervous System - immunology ; Central Nervous System - metabolism ; Central Nervous System - physiopathology ; Cerebral Arteries - cytology ; Cerebral Arteries - immunology ; costimulatory molecules ; DC-SIGN ; Encephalitis - immunology ; Encephalitis - metabolism ; Encephalitis - physiopathology ; Female ; Fundamental and applied biological sciences. Psychology ; Histocompatibility Antigens Class II - immunology ; Histocompatibility Antigens Class II - metabolism ; Humans ; Inflammation Mediators - immunology ; Inflammation Mediators - metabolism ; Isolated neuron and nerve. Neuroglia ; Lectins, C-Type - immunology ; Lectins, C-Type - metabolism ; Lymphocyte Activation - immunology ; Macrophages - immunology ; Macrophages - metabolism ; Male ; mannose receptor ; Mannose-Binding Lectins - immunology ; Mannose-Binding Lectins - metabolism ; Medical sciences ; Microcirculation - cytology ; Microcirculation - immunology ; Microglia - immunology ; Microglia - metabolism ; Middle Aged ; multiple sclerosis ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; perivascular macrophages ; Receptors, Cell Surface - immunology ; Receptors, Cell Surface - metabolism ; T-Lymphocytes - immunology ; Vertebrates: nervous system and sense organs</subject><ispartof>Glia, 2005-09, Vol.51 (4), p.297-305</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>(c) 2005 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4928-58c31e349d60b8b174d324813296766c334e72b173673d28daede487f9f9e45c3</citedby><cites>FETCH-LOGICAL-c4928-58c31e349d60b8b174d324813296766c334e72b173673d28daede487f9f9e45c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fglia.20208$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fglia.20208$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17032944$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15846794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fabriek, Babs O.</creatorcontrib><creatorcontrib>Van Haastert, Elise S.</creatorcontrib><creatorcontrib>Galea, Ian</creatorcontrib><creatorcontrib>Polfliet, Machteld M.J.</creatorcontrib><creatorcontrib>Döpp, Ed D.</creatorcontrib><creatorcontrib>Van Den Heuvel, Michel M.</creatorcontrib><creatorcontrib>Van Den Berg, Timo K.</creatorcontrib><creatorcontrib>De Groot, Corline J.A.</creatorcontrib><creatorcontrib>Van Der Valk, Paul</creatorcontrib><creatorcontrib>Dijkstra, Christine D.</creatorcontrib><title>CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation</title><title>Glia</title><addtitle>Glia</addtitle><description>Perivascular macrophages (PVM) constitute a subpopulation of resident macrophages in the central nervous system (CNS) that by virtue of their strategic location at the blood‐brain barrier potentially lend themselves to a variety of important functions in both health and disease. Functional evidence suggests that PVM play a supportive role during experimental autoimmune encephalomyelitis in rodents. However, the function of PVM in the human CNS remains poorly characterized. We first set out to investigate the validity of the antibody EDhu1, which recognizes human CD163, to specifically identify human PVM. Second, we wanted to gain insight into the function of PVM in antigen recognition and presentation and therefore we studied the expression of DC‐SIGN, mannose receptor, MHC class II, and several costimulatory molecules by PVM in the normal and inflamed human CNS (multiple sclerosis (MS) brain lesions). Conventional immunohistochemistry and double‐labeled immunofluorescence techniques were used. We show that CD163 specifically reveals PVM in the normal human CNS. In MS lesions, CD163 staining reveals expression on foamy macrophages and microglia, besides an upregulation of the amount of PVM stained. In contrast, mannose receptor expression is restricted to PVM in both normal and inflamed brain tissue. Furthermore, we show that a subpopulation of PVM in the human brain express several molecules involved in antigen recognition, presentation, and costimulation. Therefore PVM, which occupy a strategic location at the BBB, are equipped to recognize antigen and present it to T cells, supporting a role in the regulation of perivascular inflammation in the human CNS. © 2005 Wiley‐Liss, Inc.</description><subject>Aged</subject><subject>Antigen Presentation - immunology</subject><subject>antigen presentation and recognition</subject><subject>Antigen-Presenting Cells - immunology</subject><subject>Antigen-Presenting Cells - metabolism</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, Differentiation, Myelomonocytic - immunology</subject><subject>Biological and medical sciences</subject><subject>Blood-Brain Barrier - cytology</subject><subject>Blood-Brain Barrier - immunology</subject><subject>Cell Adhesion Molecules - immunology</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Central Nervous System - immunology</subject><subject>Central Nervous System - metabolism</subject><subject>Central Nervous System - physiopathology</subject><subject>Cerebral Arteries - cytology</subject><subject>Cerebral Arteries - immunology</subject><subject>costimulatory molecules</subject><subject>DC-SIGN</subject><subject>Encephalitis - immunology</subject><subject>Encephalitis - metabolism</subject><subject>Encephalitis - physiopathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Histocompatibility Antigens Class II - metabolism</subject><subject>Humans</subject><subject>Inflammation Mediators - immunology</subject><subject>Inflammation Mediators - metabolism</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Lectins, C-Type - immunology</subject><subject>Lectins, C-Type - metabolism</subject><subject>Lymphocyte Activation - immunology</subject><subject>Macrophages - immunology</subject><subject>Macrophages - metabolism</subject><subject>Male</subject><subject>mannose receptor</subject><subject>Mannose-Binding Lectins - immunology</subject><subject>Mannose-Binding Lectins - metabolism</subject><subject>Medical sciences</subject><subject>Microcirculation - cytology</subject><subject>Microcirculation - immunology</subject><subject>Microglia - immunology</subject><subject>Microglia - metabolism</subject><subject>Middle Aged</subject><subject>multiple sclerosis</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>perivascular macrophages</subject><subject>Receptors, Cell Surface - immunology</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>T-Lymphocytes - immunology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0894-1491</issn><issn>1098-1136</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALgehSuPADkC9wQErx18b2sWxhqYiWQ0E9Wl5nsmtInNROSvvvcdiF3uBkefR4Rn4HoZeUnFFC2Ltd6-0ZI4yoR2hBiVYFpbx8jBZEaVFQoekJepbSd0Jovsin6IQulSilFguUVhe05MXQJz_6W8ADRH9rk5taG3FnXeyHvd1Bwj7gcQ94P3U24NXmCsPdECEl3PUtZJ5J00dsw-h3EHAE1-9C7tmHXKvxbCGMdi48R08a2yZ4cTxP0bePH76uPhXVl_Xl6rwqnNBMFUvlOAUudF2SrdpSKWrOhKKc6VKWpeNcgGS5zkvJa6ZqCzUIJRvdaBBLx0_Rm0PfIfY3E6TRdD45aFsboJ-SKZVgSij2X5hHCEmFzPDtAeZcUorQmCH6zsZ7Q4mZd2HmXZjfu8j41bHrtO2gfqDH8DN4fQQ5cNs20Qbn04OTJH9VzI4e3E_fwv0_Rpp1dXn-Z3hxeOPTCHd_39j4w-S05NJcb9ZmQ64vqqvqvfnMfwEGZrBr</recordid><startdate>200509</startdate><enddate>200509</enddate><creator>Fabriek, Babs O.</creator><creator>Van Haastert, Elise S.</creator><creator>Galea, Ian</creator><creator>Polfliet, Machteld M.J.</creator><creator>Döpp, Ed D.</creator><creator>Van Den Heuvel, Michel M.</creator><creator>Van Den Berg, Timo K.</creator><creator>De Groot, Corline J.A.</creator><creator>Van Der Valk, Paul</creator><creator>Dijkstra, Christine D.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200509</creationdate><title>CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation</title><author>Fabriek, Babs O. ; Van Haastert, Elise S. ; Galea, Ian ; Polfliet, Machteld M.J. ; Döpp, Ed D. ; Van Den Heuvel, Michel M. ; Van Den Berg, Timo K. ; De Groot, Corline J.A. ; Van Der Valk, Paul ; Dijkstra, Christine D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4928-58c31e349d60b8b174d324813296766c334e72b173673d28daede487f9f9e45c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>Antigen Presentation - immunology</topic><topic>antigen presentation and recognition</topic><topic>Antigen-Presenting Cells - immunology</topic><topic>Antigen-Presenting Cells - metabolism</topic><topic>Antigens, CD - immunology</topic><topic>Antigens, Differentiation, Myelomonocytic - immunology</topic><topic>Biological and medical sciences</topic><topic>Blood-Brain Barrier - cytology</topic><topic>Blood-Brain Barrier - immunology</topic><topic>Cell Adhesion Molecules - immunology</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Central Nervous System - immunology</topic><topic>Central Nervous System - metabolism</topic><topic>Central Nervous System - physiopathology</topic><topic>Cerebral Arteries - cytology</topic><topic>Cerebral Arteries - immunology</topic><topic>costimulatory molecules</topic><topic>DC-SIGN</topic><topic>Encephalitis - immunology</topic><topic>Encephalitis - metabolism</topic><topic>Encephalitis - physiopathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histocompatibility Antigens Class II - immunology</topic><topic>Histocompatibility Antigens Class II - metabolism</topic><topic>Humans</topic><topic>Inflammation Mediators - immunology</topic><topic>Inflammation Mediators - metabolism</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Lectins, C-Type - immunology</topic><topic>Lectins, C-Type - metabolism</topic><topic>Lymphocyte Activation - immunology</topic><topic>Macrophages - immunology</topic><topic>Macrophages - metabolism</topic><topic>Male</topic><topic>mannose receptor</topic><topic>Mannose-Binding Lectins - immunology</topic><topic>Mannose-Binding Lectins - metabolism</topic><topic>Medical sciences</topic><topic>Microcirculation - cytology</topic><topic>Microcirculation - immunology</topic><topic>Microglia - immunology</topic><topic>Microglia - metabolism</topic><topic>Middle Aged</topic><topic>multiple sclerosis</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>perivascular macrophages</topic><topic>Receptors, Cell Surface - immunology</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>T-Lymphocytes - immunology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fabriek, Babs O.</creatorcontrib><creatorcontrib>Van Haastert, Elise S.</creatorcontrib><creatorcontrib>Galea, Ian</creatorcontrib><creatorcontrib>Polfliet, Machteld M.J.</creatorcontrib><creatorcontrib>Döpp, Ed D.</creatorcontrib><creatorcontrib>Van Den Heuvel, Michel M.</creatorcontrib><creatorcontrib>Van Den Berg, Timo K.</creatorcontrib><creatorcontrib>De Groot, Corline J.A.</creatorcontrib><creatorcontrib>Van Der Valk, Paul</creatorcontrib><creatorcontrib>Dijkstra, Christine D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Glia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fabriek, Babs O.</au><au>Van Haastert, Elise S.</au><au>Galea, Ian</au><au>Polfliet, Machteld M.J.</au><au>Döpp, Ed D.</au><au>Van Den Heuvel, Michel M.</au><au>Van Den Berg, Timo K.</au><au>De Groot, Corline J.A.</au><au>Van Der Valk, Paul</au><au>Dijkstra, Christine D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation</atitle><jtitle>Glia</jtitle><addtitle>Glia</addtitle><date>2005-09</date><risdate>2005</risdate><volume>51</volume><issue>4</issue><spage>297</spage><epage>305</epage><pages>297-305</pages><issn>0894-1491</issn><eissn>1098-1136</eissn><coden>GLIAEJ</coden><abstract>Perivascular macrophages (PVM) constitute a subpopulation of resident macrophages in the central nervous system (CNS) that by virtue of their strategic location at the blood‐brain barrier potentially lend themselves to a variety of important functions in both health and disease. Functional evidence suggests that PVM play a supportive role during experimental autoimmune encephalomyelitis in rodents. However, the function of PVM in the human CNS remains poorly characterized. We first set out to investigate the validity of the antibody EDhu1, which recognizes human CD163, to specifically identify human PVM. Second, we wanted to gain insight into the function of PVM in antigen recognition and presentation and therefore we studied the expression of DC‐SIGN, mannose receptor, MHC class II, and several costimulatory molecules by PVM in the normal and inflamed human CNS (multiple sclerosis (MS) brain lesions). Conventional immunohistochemistry and double‐labeled immunofluorescence techniques were used. We show that CD163 specifically reveals PVM in the normal human CNS. In MS lesions, CD163 staining reveals expression on foamy macrophages and microglia, besides an upregulation of the amount of PVM stained. In contrast, mannose receptor expression is restricted to PVM in both normal and inflamed brain tissue. Furthermore, we show that a subpopulation of PVM in the human brain express several molecules involved in antigen recognition, presentation, and costimulation. Therefore PVM, which occupy a strategic location at the BBB, are equipped to recognize antigen and present it to T cells, supporting a role in the regulation of perivascular inflammation in the human CNS. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15846794</pmid><doi>10.1002/glia.20208</doi><tpages>9</tpages></addata></record> |
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| ispartof | Glia, 2005-09, Vol.51 (4), p.297-305 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Antigen Presentation - immunology antigen presentation and recognition Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Antigens, CD - immunology Antigens, Differentiation, Myelomonocytic - immunology Biological and medical sciences Blood-Brain Barrier - cytology Blood-Brain Barrier - immunology Cell Adhesion Molecules - immunology Cell Adhesion Molecules - metabolism Central Nervous System - immunology Central Nervous System - metabolism Central Nervous System - physiopathology Cerebral Arteries - cytology Cerebral Arteries - immunology costimulatory molecules DC-SIGN Encephalitis - immunology Encephalitis - metabolism Encephalitis - physiopathology Female Fundamental and applied biological sciences. Psychology Histocompatibility Antigens Class II - immunology Histocompatibility Antigens Class II - metabolism Humans Inflammation Mediators - immunology Inflammation Mediators - metabolism Isolated neuron and nerve. Neuroglia Lectins, C-Type - immunology Lectins, C-Type - metabolism Lymphocyte Activation - immunology Macrophages - immunology Macrophages - metabolism Male mannose receptor Mannose-Binding Lectins - immunology Mannose-Binding Lectins - metabolism Medical sciences Microcirculation - cytology Microcirculation - immunology Microglia - immunology Microglia - metabolism Middle Aged multiple sclerosis Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology perivascular macrophages Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism T-Lymphocytes - immunology Vertebrates: nervous system and sense organs |
| title | CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation |
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