Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study
Summary Objective Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5‐year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese. Design...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 2007-02, Vol.66 (2), p.211-217 |
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| creator | Xu, Jian Yu Sham, Pak C. Xu, Aimin Tso, Annette W. K. Wat, Nelson M. S. Cheng, King Yip Fong, Carol H. Y. Janus, Edward D. Lam, Karen S. L. |
| description | Summary
Objective Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5‐year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese.
Design and patients We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, −420C→G and +62G→A, previously reported in cross‐sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort.
Results We identified 15 polymorphisms, including 2 novel but rare polymorphisms (−319G→A and +63G→C). Compared to subjects with the CC genotype, −420GG subjects had higher 2‐h glucose (7·7 ± 1·8 vs. 7·2 ± 2·0 mmol/l, P = 0·011) and insulin (101·6 ± 69·5 vs. 79·8 ± 59·5 mU/l, P = 0·021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25·3 ± 4·0 vs. 24·5 ± 3·6 kg/m2 in GG, P = 0·02). The presence of the allele −420G (OR 2·15, 95% CI 1·28–3·60, P = 0·004) or +62A (OR1·86, 95% CI 1·08–3·21, P = 0·025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G‐A also conferred a higher risk of progression in glycaemia (P = 0·002).
Conclusion Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese. |
| doi_str_mv | 10.1111/j.1365-2265.2006.02710.x |
| format | Article |
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Objective Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5‐year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese.
Design and patients We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, −420C→G and +62G→A, previously reported in cross‐sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort.
Results We identified 15 polymorphisms, including 2 novel but rare polymorphisms (−319G→A and +63G→C). Compared to subjects with the CC genotype, −420GG subjects had higher 2‐h glucose (7·7 ± 1·8 vs. 7·2 ± 2·0 mmol/l, P = 0·011) and insulin (101·6 ± 69·5 vs. 79·8 ± 59·5 mU/l, P = 0·021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25·3 ± 4·0 vs. 24·5 ± 3·6 kg/m2 in GG, P = 0·02). The presence of the allele −420G (OR 2·15, 95% CI 1·28–3·60, P = 0·004) or +62A (OR1·86, 95% CI 1·08–3·21, P = 0·025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G‐A also conferred a higher risk of progression in glycaemia (P = 0·002).
Conclusion Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2006.02710.x</identifier><identifier>PMID: 17223990</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; China ; Disease Progression ; Endocrinopathies ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genotype ; Humans ; Hyperglycemia - genetics ; Insulin Resistance - genetics ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Obesity - genetics ; Polymorphism, Single Nucleotide ; Prospective Studies ; Resistin - genetics ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2007-02, Vol.66 (2), p.211-217</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5010-152ee4cc3c02c1f2dedd557ee44d357a04a271be84a8f2bfd1374e09dc5153ae3</citedby><cites>FETCH-LOGICAL-c5010-152ee4cc3c02c1f2dedd557ee44d357a04a271be84a8f2bfd1374e09dc5153ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2006.02710.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2006.02710.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18487469$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17223990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Jian Yu</creatorcontrib><creatorcontrib>Sham, Pak C.</creatorcontrib><creatorcontrib>Xu, Aimin</creatorcontrib><creatorcontrib>Tso, Annette W. K.</creatorcontrib><creatorcontrib>Wat, Nelson M. S.</creatorcontrib><creatorcontrib>Cheng, King Yip</creatorcontrib><creatorcontrib>Fong, Carol H. Y.</creatorcontrib><creatorcontrib>Janus, Edward D.</creatorcontrib><creatorcontrib>Lam, Karen S. L.</creatorcontrib><title>Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5‐year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese.
Design and patients We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, −420C→G and +62G→A, previously reported in cross‐sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort.
Results We identified 15 polymorphisms, including 2 novel but rare polymorphisms (−319G→A and +63G→C). Compared to subjects with the CC genotype, −420GG subjects had higher 2‐h glucose (7·7 ± 1·8 vs. 7·2 ± 2·0 mmol/l, P = 0·011) and insulin (101·6 ± 69·5 vs. 79·8 ± 59·5 mU/l, P = 0·021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25·3 ± 4·0 vs. 24·5 ± 3·6 kg/m2 in GG, P = 0·02). The presence of the allele −420G (OR 2·15, 95% CI 1·28–3·60, P = 0·004) or +62A (OR1·86, 95% CI 1·08–3·21, P = 0·025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G‐A also conferred a higher risk of progression in glycaemia (P = 0·002).
Conclusion Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>China</subject><subject>Disease Progression</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Hyperglycemia - genetics</subject><subject>Insulin Resistance - genetics</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obesity - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prospective Studies</subject><subject>Resistin - genetics</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuP0zAURi0EYsrAX0DewC7l-hWnSCxQNAyIahBoeOws17lpXfIodgLNv8eh1cwWb2z5nmNffyaEMliyNF7tl0zkKuM8V0sOkC-B61Q7PiCLu8JDsgABkEGeywvyJMY9AKgC9GNywTTnYrWCBdl9wejj4Du6xQ7poW-mtg-HnY9tpLar6CH024Ax-r6jfU23zeQstt7SpMR-HHYYOlrufIcRX1NLVTahDbMWD-gG_xtpHMZqekoe1baJ-Ow8X5Kv765uy_fZ-tP1h_LtOnMKGGRMcUTpnHDAHat5hVWllE57shJKW5A2PXWDhbRFzTd1xYSWCKvKKaaERXFJXp7OTR38GjEOpvXRYdPYDvsxmryQXEuZJ7A4gS61GgPW5hB8a8NkGJg5ZbM3c5hmDtPMKZt_KZtjUp-f7xg3LVb34jnWBLw4AzY629TBds7He66QhZb5KnFvTtwf3-D03w2Y8upmXiU_O_npC_F459vw0-RaaGW-31wb_XHNf9x-_mZK8ReBRKkP</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Xu, Jian Yu</creator><creator>Sham, Pak C.</creator><creator>Xu, Aimin</creator><creator>Tso, Annette W. K.</creator><creator>Wat, Nelson M. S.</creator><creator>Cheng, King Yip</creator><creator>Fong, Carol H. Y.</creator><creator>Janus, Edward D.</creator><creator>Lam, Karen S. L.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study</title><author>Xu, Jian Yu ; Sham, Pak C. ; Xu, Aimin ; Tso, Annette W. K. ; Wat, Nelson M. S. ; Cheng, King Yip ; Fong, Carol H. Y. ; Janus, Edward D. ; Lam, Karen S. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5010-152ee4cc3c02c1f2dedd557ee44d357a04a271be84a8f2bfd1374e09dc5153ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>China</topic><topic>Disease Progression</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Hyperglycemia - genetics</topic><topic>Insulin Resistance - genetics</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obesity - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prospective Studies</topic><topic>Resistin - genetics</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Jian Yu</creatorcontrib><creatorcontrib>Sham, Pak C.</creatorcontrib><creatorcontrib>Xu, Aimin</creatorcontrib><creatorcontrib>Tso, Annette W. K.</creatorcontrib><creatorcontrib>Wat, Nelson M. S.</creatorcontrib><creatorcontrib>Cheng, King Yip</creatorcontrib><creatorcontrib>Fong, Carol H. Y.</creatorcontrib><creatorcontrib>Janus, Edward D.</creatorcontrib><creatorcontrib>Lam, Karen S. L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Jian Yu</au><au>Sham, Pak C.</au><au>Xu, Aimin</au><au>Tso, Annette W. K.</au><au>Wat, Nelson M. S.</au><au>Cheng, King Yip</au><au>Fong, Carol H. Y.</au><au>Janus, Edward D.</au><au>Lam, Karen S. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2007-02</date><risdate>2007</risdate><volume>66</volume><issue>2</issue><spage>211</spage><epage>217</epage><pages>211-217</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5‐year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese.
Design and patients We conducted a systematic search for variants in RETN in 70 southern Chinese subjects. This was followed by the genotyping in 624 unrelated nondiabetic subjects of two polymorphisms, −420C→G and +62G→A, previously reported in cross‐sectional studies to be associated with T2DM in Asians, to examine their relationship with the progression of glycaemia in this cohort.
Results We identified 15 polymorphisms, including 2 novel but rare polymorphisms (−319G→A and +63G→C). Compared to subjects with the CC genotype, −420GG subjects had higher 2‐h glucose (7·7 ± 1·8 vs. 7·2 ± 2·0 mmol/l, P = 0·011) and insulin (101·6 ± 69·5 vs. 79·8 ± 59·5 mU/l, P = 0·021) during an oral glucose tolerance test. Carriers of the +62A allele had higher body mass indices (25·3 ± 4·0 vs. 24·5 ± 3·6 kg/m2 in GG, P = 0·02). The presence of the allele −420G (OR 2·15, 95% CI 1·28–3·60, P = 0·004) or +62A (OR1·86, 95% CI 1·08–3·21, P = 0·025) predicted the progression of glycaemia at Year 5, after adjustment for sex, age or body mass index. The haplotype G‐A also conferred a higher risk of progression in glycaemia (P = 0·002).
Conclusion Our study would support the role of the resistin gene in obesity, insulin resistance and progression of glycaemia in southern Chinese.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17223990</pmid><doi>10.1111/j.1365-2265.2006.02710.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences China Disease Progression Endocrinopathies Female Fundamental and applied biological sciences. Psychology Gene Frequency Genotype Humans Hyperglycemia - genetics Insulin Resistance - genetics Longitudinal Studies Male Medical sciences Middle Aged Obesity - genetics Polymorphism, Single Nucleotide Prospective Studies Resistin - genetics Vertebrates: endocrinology |
| title | Resistin gene polymorphisms and progression of glycaemia in southern Chinese: a 5-year prospective study |
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