Treatment of actinomycetoma due to Nocardia spp. with amoxicillin-clavulanate
Summary Background Actinomycetoma is a chronic occupational condition that occurs frequently in tropical regions. In Mexico 85% of cases are caused by Nocardia brasiliensis. There are two treatments of choice for these cases: a regimen of dapsone plus trimethoprim–sulfamethoxazole (co‐trimoxazole)...
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| Veröffentlicht in: | British journal of dermatology (1951) 2007-02, Vol.156 (2), p.308-311 |
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| container_title | British journal of dermatology (1951) |
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| creator | Bonifaz, A. Flores, P. Saúl, A. Carrasco-Gerard, E. Ponce, R.M. |
| description | Summary
Background Actinomycetoma is a chronic occupational condition that occurs frequently in tropical regions. In Mexico 85% of cases are caused by Nocardia brasiliensis. There are two treatments of choice for these cases: a regimen of dapsone plus trimethoprim–sulfamethoxazole (co‐trimoxazole) and, recently, amikacin, either alone or combined. However, not all cases respond properly to these therapies.
Objectives To report a retrospective, 11‐year study of cases of actinomycetomas caused by Nocardia spp., treated with amoxicillin–clavulanate (co‐amoxiclav).
Methods All cases were identified clinically and microbiologically and had previously failed standard therapies. Oral co‐amoxiclav 875/125 mg was administered every 12 h. Clinical, microbiological and laboratory follow up was performed every 2 months during the treatment period.
Results Twenty‐one cases of actinomycetoma were included, 19 caused by N. brasiliensis and one each by N. asteroides and N. otitidiscaviarum. Clinical and microbiological cure occurred in 15 of 21 cases (71%); two cases improved (10%) and four failed (19%). Mean treatment period was 9·6 months, during which neither side‐effects nor laboratory test alterations were reported.
Conclusions Treatment with co‐amoxiclav represents an alternative or rescue treatment for cases that have previously failed standard therapies. |
| doi_str_mv | 10.1111/j.1365-2133.2006.07557.x |
| format | Article |
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Background Actinomycetoma is a chronic occupational condition that occurs frequently in tropical regions. In Mexico 85% of cases are caused by Nocardia brasiliensis. There are two treatments of choice for these cases: a regimen of dapsone plus trimethoprim–sulfamethoxazole (co‐trimoxazole) and, recently, amikacin, either alone or combined. However, not all cases respond properly to these therapies.
Objectives To report a retrospective, 11‐year study of cases of actinomycetomas caused by Nocardia spp., treated with amoxicillin–clavulanate (co‐amoxiclav).
Methods All cases were identified clinically and microbiologically and had previously failed standard therapies. Oral co‐amoxiclav 875/125 mg was administered every 12 h. Clinical, microbiological and laboratory follow up was performed every 2 months during the treatment period.
Results Twenty‐one cases of actinomycetoma were included, 19 caused by N. brasiliensis and one each by N. asteroides and N. otitidiscaviarum. Clinical and microbiological cure occurred in 15 of 21 cases (71%); two cases improved (10%) and four failed (19%). Mean treatment period was 9·6 months, during which neither side‐effects nor laboratory test alterations were reported.
Conclusions Treatment with co‐amoxiclav represents an alternative or rescue treatment for cases that have previously failed standard therapies.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2006.07557.x</identifier><identifier>PMID: 17223871</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>actinomycetoma ; Adult ; Aged ; Amikacin - therapeutic use ; Amoxicillin-Potassium Clavulanate Combination - therapeutic use ; Anti-Bacterial Agents - therapeutic use ; co-amoxiclav ; Dapsone - therapeutic use ; Drug Therapy, Combination ; Follow-Up Studies ; Humans ; Male ; Mexico ; Middle Aged ; mycetoma ; Nocardia brasiliensis ; Nocardia Infections - drug therapy ; Nocardia sp ; Retrospective Studies ; Skin Diseases, Bacterial - drug therapy ; Skin Diseases, Bacterial - microbiology ; Treatment Outcome</subject><ispartof>British journal of dermatology (1951), 2007-02, Vol.156 (2), p.308-311</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4367-8ba854401b4bd72ba1260920f32398240b5b4e520dc07b2affb5a93430cdd08d3</citedby><cites>FETCH-LOGICAL-c4367-8ba854401b4bd72ba1260920f32398240b5b4e520dc07b2affb5a93430cdd08d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2006.07557.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2006.07557.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17223871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonifaz, A.</creatorcontrib><creatorcontrib>Flores, P.</creatorcontrib><creatorcontrib>Saúl, A.</creatorcontrib><creatorcontrib>Carrasco-Gerard, E.</creatorcontrib><creatorcontrib>Ponce, R.M.</creatorcontrib><title>Treatment of actinomycetoma due to Nocardia spp. with amoxicillin-clavulanate</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Actinomycetoma is a chronic occupational condition that occurs frequently in tropical regions. In Mexico 85% of cases are caused by Nocardia brasiliensis. There are two treatments of choice for these cases: a regimen of dapsone plus trimethoprim–sulfamethoxazole (co‐trimoxazole) and, recently, amikacin, either alone or combined. However, not all cases respond properly to these therapies.
Objectives To report a retrospective, 11‐year study of cases of actinomycetomas caused by Nocardia spp., treated with amoxicillin–clavulanate (co‐amoxiclav).
Methods All cases were identified clinically and microbiologically and had previously failed standard therapies. Oral co‐amoxiclav 875/125 mg was administered every 12 h. Clinical, microbiological and laboratory follow up was performed every 2 months during the treatment period.
Results Twenty‐one cases of actinomycetoma were included, 19 caused by N. brasiliensis and one each by N. asteroides and N. otitidiscaviarum. Clinical and microbiological cure occurred in 15 of 21 cases (71%); two cases improved (10%) and four failed (19%). Mean treatment period was 9·6 months, during which neither side‐effects nor laboratory test alterations were reported.
Conclusions Treatment with co‐amoxiclav represents an alternative or rescue treatment for cases that have previously failed standard therapies.</description><subject>actinomycetoma</subject><subject>Adult</subject><subject>Aged</subject><subject>Amikacin - therapeutic use</subject><subject>Amoxicillin-Potassium Clavulanate Combination - therapeutic use</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>co-amoxiclav</subject><subject>Dapsone - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>mycetoma</subject><subject>Nocardia brasiliensis</subject><subject>Nocardia Infections - drug therapy</subject><subject>Nocardia sp</subject><subject>Retrospective Studies</subject><subject>Skin Diseases, Bacterial - drug therapy</subject><subject>Skin Diseases, Bacterial - microbiology</subject><subject>Treatment Outcome</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEFv0zAYQC0EYt3gLyCfuCX77M-O0wMH2GCAxtBEYUfLdhzhktQldlj770loNY7giy35vc_WI4QyKNm0ztclw0oWnCGWHKAqQUmpyt0jsni4eEwWAKAKWFZ4Qk5TWgMwBAlPyQlTnGOt2IJ8Wg3e5N5vMo0tNS6HTez3zufYG9qMnuZIb6IzQxMMTdttSe9D_k5NH3fBha4Lm8J15tfYmY3J_hl50pou-efH_Yx8ffd2dfG-uP589eHi9XXhBFaqqK2ppRDArLCN4tYwXsGSQ4sclzUXYKUVXnJoHCjLTdtaaZYoEFzTQN3gGXl5mLsd4s_Rp6z7kJzvpl_4OCZd1YIrlPU_QQ5CcEA1gfUBdENMafCt3g6hN8NeM9Bzc73Wc1o9p9Vzc_2nud5N6ovjG6PtffNXPEaegFcH4D50fv_fg_Wbj5fzafKLgx9S9rsH3ww_dKVQSX13c6Xx7vby9stqpb_hb5cFnqs</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Bonifaz, A.</creator><creator>Flores, P.</creator><creator>Saúl, A.</creator><creator>Carrasco-Gerard, E.</creator><creator>Ponce, R.M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>Treatment of actinomycetoma due to Nocardia spp. with amoxicillin-clavulanate</title><author>Bonifaz, A. ; Flores, P. ; Saúl, A. ; Carrasco-Gerard, E. ; Ponce, R.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4367-8ba854401b4bd72ba1260920f32398240b5b4e520dc07b2affb5a93430cdd08d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>actinomycetoma</topic><topic>Adult</topic><topic>Aged</topic><topic>Amikacin - therapeutic use</topic><topic>Amoxicillin-Potassium Clavulanate Combination - therapeutic use</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>co-amoxiclav</topic><topic>Dapsone - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Mexico</topic><topic>Middle Aged</topic><topic>mycetoma</topic><topic>Nocardia brasiliensis</topic><topic>Nocardia Infections - drug therapy</topic><topic>Nocardia sp</topic><topic>Retrospective Studies</topic><topic>Skin Diseases, Bacterial - drug therapy</topic><topic>Skin Diseases, Bacterial - microbiology</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonifaz, A.</creatorcontrib><creatorcontrib>Flores, P.</creatorcontrib><creatorcontrib>Saúl, A.</creatorcontrib><creatorcontrib>Carrasco-Gerard, E.</creatorcontrib><creatorcontrib>Ponce, R.M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonifaz, A.</au><au>Flores, P.</au><au>Saúl, A.</au><au>Carrasco-Gerard, E.</au><au>Ponce, R.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of actinomycetoma due to Nocardia spp. with amoxicillin-clavulanate</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2007-02</date><risdate>2007</risdate><volume>156</volume><issue>2</issue><spage>308</spage><epage>311</epage><pages>308-311</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><abstract>Summary
Background Actinomycetoma is a chronic occupational condition that occurs frequently in tropical regions. In Mexico 85% of cases are caused by Nocardia brasiliensis. There are two treatments of choice for these cases: a regimen of dapsone plus trimethoprim–sulfamethoxazole (co‐trimoxazole) and, recently, amikacin, either alone or combined. However, not all cases respond properly to these therapies.
Objectives To report a retrospective, 11‐year study of cases of actinomycetomas caused by Nocardia spp., treated with amoxicillin–clavulanate (co‐amoxiclav).
Methods All cases were identified clinically and microbiologically and had previously failed standard therapies. Oral co‐amoxiclav 875/125 mg was administered every 12 h. Clinical, microbiological and laboratory follow up was performed every 2 months during the treatment period.
Results Twenty‐one cases of actinomycetoma were included, 19 caused by N. brasiliensis and one each by N. asteroides and N. otitidiscaviarum. Clinical and microbiological cure occurred in 15 of 21 cases (71%); two cases improved (10%) and four failed (19%). Mean treatment period was 9·6 months, during which neither side‐effects nor laboratory test alterations were reported.
Conclusions Treatment with co‐amoxiclav represents an alternative or rescue treatment for cases that have previously failed standard therapies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17223871</pmid><doi>10.1111/j.1365-2133.2006.07557.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | British journal of dermatology (1951), 2007-02, Vol.156 (2), p.308-311 |
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| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | actinomycetoma Adult Aged Amikacin - therapeutic use Amoxicillin-Potassium Clavulanate Combination - therapeutic use Anti-Bacterial Agents - therapeutic use co-amoxiclav Dapsone - therapeutic use Drug Therapy, Combination Follow-Up Studies Humans Male Mexico Middle Aged mycetoma Nocardia brasiliensis Nocardia Infections - drug therapy Nocardia sp Retrospective Studies Skin Diseases, Bacterial - drug therapy Skin Diseases, Bacterial - microbiology Treatment Outcome |
| title | Treatment of actinomycetoma due to Nocardia spp. with amoxicillin-clavulanate |
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