Hepatitis C virus envelope glycoprotein immunization of rodents elicits cross-reactive neutralizing antibodies

Abstract Neutralizing antibody responses elicited during infection generally confer protection from infection. Hepatitis C virus (HCV) encodes two glycoproteins E1 and E2 that are essential for virus entry and are the major target for neutralizing antibodies. To assess whether both glycoproteins are...

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Veröffentlicht in:	Vaccine 2007-11, Vol.25 (45), p.7773-7784
Hauptverfasser:	Stamataki, Zania, Coates, Stephen, Evans, Matthew J, Wininger, Mark, Crawford, Kevin, Dong, Christine, Fong, Yiu-lian, Chien, David, Abrignani, Sergio, Balfe, Peter, Rice, Charles M, McKeating, Jane A, Houghton, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Applied microbiology Biological and medical sciences Cell Culture Techniques Chronic illnesses Cross Reactions E1E2 Fundamental and applied biological sciences. Psychology Genotype Glycoproteins Guinea pig HCV Hepacivirus - chemistry Hepacivirus - genetics Hepacivirus - immunology Hepatitis Hepatitis C - genetics Hepatitis C - immunology Hepatitis C Antibodies - immunology Hepatitis C virus HIV Human immunodeficiency virus Immunization Immunogenicity Microbiology Miscellaneous Neutralization Neutralization Tests Rodentia Rodents Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology Virology
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