Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population
A converging body of evidence implicates the γ-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2005-09, Vol.334 (3), p.817-823 |
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| creator | Liu, Jixia Shi, Yongyong Tang, Wei Guo, Tingwei Li, Dawei Yang, Yifeng Zhao, Xinzhi Wang, Hongsheng Li, Xingwang Feng, Guoyin Gu, Niufan Zhu, Shaomin Liu, Huijun Guo, Yangling Shi, Jianguo Sang, Hong Yan, Lijuan He, Lin |
| description | A converging body of evidence implicates the γ-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269. To validate this linkage disequilibrium report, we genotyped these five SNPs and additional rs1816072 in 352 Chinese Han family trios. Though we failed to detect any positive results in single markers, we did find a significant haplotypic association (global
p
=
0.00157–0.00588) which had not been identified in Lo’s study. Our data indicated that the haplotype ‘GACTCT’ (
p
=
0.00215, frequency
=
53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia. |
| doi_str_mv | 10.1016/j.bbrc.2005.06.167 |
| format | Article |
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p
=
0.00157–0.00588) which had not been identified in Lo’s study. Our data indicated that the haplotype ‘GACTCT’ (
p
=
0.00215, frequency
=
53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2005.06.167</identifier><identifier>PMID: 16023997</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Asian Continental Ancestry Group - genetics ; Association ; Ethnic Groups - genetics ; Female ; GABAergic neurotransmission system ; GABRB2 ; Haplotype ; Haplotypes - genetics ; Humans ; Linkage Disequilibrium ; Male ; Polymorphism, Single Nucleotide ; Receptors, GABA-A - genetics ; Schizophrenia - ethnology ; Schizophrenia - genetics ; Transmission disequilibrium</subject><ispartof>Biochemical and biophysical research communications, 2005-09, Vol.334 (3), p.817-823</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-8b70a2d3abb7a7353c3a52a42581cf9cff251fb4c925ea07bc56a9e49c44ee763</citedby><cites>FETCH-LOGICAL-c385t-8b70a2d3abb7a7353c3a52a42581cf9cff251fb4c925ea07bc56a9e49c44ee763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2005.06.167$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16023997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jixia</creatorcontrib><creatorcontrib>Shi, Yongyong</creatorcontrib><creatorcontrib>Tang, Wei</creatorcontrib><creatorcontrib>Guo, Tingwei</creatorcontrib><creatorcontrib>Li, Dawei</creatorcontrib><creatorcontrib>Yang, Yifeng</creatorcontrib><creatorcontrib>Zhao, Xinzhi</creatorcontrib><creatorcontrib>Wang, Hongsheng</creatorcontrib><creatorcontrib>Li, Xingwang</creatorcontrib><creatorcontrib>Feng, Guoyin</creatorcontrib><creatorcontrib>Gu, Niufan</creatorcontrib><creatorcontrib>Zhu, Shaomin</creatorcontrib><creatorcontrib>Liu, Huijun</creatorcontrib><creatorcontrib>Guo, Yangling</creatorcontrib><creatorcontrib>Shi, Jianguo</creatorcontrib><creatorcontrib>Sang, Hong</creatorcontrib><creatorcontrib>Yan, Lijuan</creatorcontrib><creatorcontrib>He, Lin</creatorcontrib><title>Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>A converging body of evidence implicates the γ-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269. To validate this linkage disequilibrium report, we genotyped these five SNPs and additional rs1816072 in 352 Chinese Han family trios. Though we failed to detect any positive results in single markers, we did find a significant haplotypic association (global
p
=
0.00157–0.00588) which had not been identified in Lo’s study. Our data indicated that the haplotype ‘GACTCT’ (
p
=
0.00215, frequency
=
53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia.</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Association</subject><subject>Ethnic Groups - genetics</subject><subject>Female</subject><subject>GABAergic neurotransmission system</subject><subject>GABRB2</subject><subject>Haplotype</subject><subject>Haplotypes - genetics</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, GABA-A - genetics</subject><subject>Schizophrenia - ethnology</subject><subject>Schizophrenia - genetics</subject><subject>Transmission disequilibrium</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQQC1ERbeFP8AB-cQtYewkdixxWVb0Q6pEDyBxs2zvhHiVjYPtFJUTP73Z7krc4DSXN2-keYS8ZVAyYOLDrrQ2upIDNCWIkgn5gqwYKCg4g_olWQGAKLhi38_JRUo7AMZqoV6RcyaAV0rJFflzH5LP_gGpSSk4b7IPIw0dzT3Sft6bkV6vP62LdRHR4ZRDpBazoZym2c6jz_QHjgtppiHkxwnpL597mlzvf4epjzh6Q_34bNv0fsSE9GZxTmGah-dbr8lZZ4aEb07zkny7-vx1c1Pcfbm-3azvCle1TS5aK8HwbWWslUZWTeUq03BT86ZlrlOu63jDOls7xRs0IK1rhFFYK1fXiFJUl-T90TvF8HPGlPXeJ4fDYEYMc9Kirbngkv0XZFJwJaBdQH4EXQwpRez0FP3exEfNQB8C6Z0-BNKHQBqEXgItS-9O9tnucft35VRkAT4eAVye8eAx6uQ8jg63fimQ9Tb4f_mfADNIo1s</recordid><startdate>20050902</startdate><enddate>20050902</enddate><creator>Liu, Jixia</creator><creator>Shi, Yongyong</creator><creator>Tang, Wei</creator><creator>Guo, Tingwei</creator><creator>Li, Dawei</creator><creator>Yang, Yifeng</creator><creator>Zhao, Xinzhi</creator><creator>Wang, Hongsheng</creator><creator>Li, Xingwang</creator><creator>Feng, Guoyin</creator><creator>Gu, Niufan</creator><creator>Zhu, Shaomin</creator><creator>Liu, Huijun</creator><creator>Guo, Yangling</creator><creator>Shi, Jianguo</creator><creator>Sang, Hong</creator><creator>Yan, Lijuan</creator><creator>He, Lin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050902</creationdate><title>Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population</title><author>Liu, Jixia ; Shi, Yongyong ; Tang, Wei ; Guo, Tingwei ; Li, Dawei ; Yang, Yifeng ; Zhao, Xinzhi ; Wang, Hongsheng ; Li, Xingwang ; Feng, Guoyin ; Gu, Niufan ; Zhu, Shaomin ; Liu, Huijun ; Guo, Yangling ; Shi, Jianguo ; Sang, Hong ; Yan, Lijuan ; He, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-8b70a2d3abb7a7353c3a52a42581cf9cff251fb4c925ea07bc56a9e49c44ee763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Association</topic><topic>Ethnic Groups - genetics</topic><topic>Female</topic><topic>GABAergic neurotransmission system</topic><topic>GABRB2</topic><topic>Haplotype</topic><topic>Haplotypes - genetics</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, GABA-A - genetics</topic><topic>Schizophrenia - ethnology</topic><topic>Schizophrenia - genetics</topic><topic>Transmission disequilibrium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jixia</creatorcontrib><creatorcontrib>Shi, Yongyong</creatorcontrib><creatorcontrib>Tang, Wei</creatorcontrib><creatorcontrib>Guo, Tingwei</creatorcontrib><creatorcontrib>Li, Dawei</creatorcontrib><creatorcontrib>Yang, Yifeng</creatorcontrib><creatorcontrib>Zhao, Xinzhi</creatorcontrib><creatorcontrib>Wang, Hongsheng</creatorcontrib><creatorcontrib>Li, Xingwang</creatorcontrib><creatorcontrib>Feng, Guoyin</creatorcontrib><creatorcontrib>Gu, Niufan</creatorcontrib><creatorcontrib>Zhu, Shaomin</creatorcontrib><creatorcontrib>Liu, Huijun</creatorcontrib><creatorcontrib>Guo, Yangling</creatorcontrib><creatorcontrib>Shi, Jianguo</creatorcontrib><creatorcontrib>Sang, Hong</creatorcontrib><creatorcontrib>Yan, Lijuan</creatorcontrib><creatorcontrib>He, Lin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jixia</au><au>Shi, Yongyong</au><au>Tang, Wei</au><au>Guo, Tingwei</au><au>Li, Dawei</au><au>Yang, Yifeng</au><au>Zhao, Xinzhi</au><au>Wang, Hongsheng</au><au>Li, Xingwang</au><au>Feng, Guoyin</au><au>Gu, Niufan</au><au>Zhu, Shaomin</au><au>Liu, Huijun</au><au>Guo, Yangling</au><au>Shi, Jianguo</au><au>Sang, Hong</au><au>Yan, Lijuan</au><au>He, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2005-09-02</date><risdate>2005</risdate><volume>334</volume><issue>3</issue><spage>817</spage><epage>823</epage><pages>817-823</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>A converging body of evidence implicates the γ-amino butyric acid neurotransmitter system in the pathogenesis of schizophrenia. Recently, Lo et al. reported strong positive association between schizophrenia and GABRB2, demonstrated by single markers and haplotypes of five markers in introns of GABRB2, rs6556547, rs1816071, rs194072, rs252944, and rs187269. To validate this linkage disequilibrium report, we genotyped these five SNPs and additional rs1816072 in 352 Chinese Han family trios. Though we failed to detect any positive results in single markers, we did find a significant haplotypic association (global
p
=
0.00157–0.00588) which had not been identified in Lo’s study. Our data indicated that the haplotype ‘GACTCT’ (
p
=
0.00215, frequency
=
53.6%) was overtransmitted which suggests that GABRB2 is in linkage disequilibrium with schizophrenia in the Chinese Han population. The difference between the two studies may be due to the respective analytic power of the two designs. These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16023997</pmid><doi>10.1016/j.bbrc.2005.06.167</doi><tpages>7</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2005-09, Vol.334 (3), p.817-823 |
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| subjects | Asian Continental Ancestry Group - genetics Association Ethnic Groups - genetics Female GABAergic neurotransmission system GABRB2 Haplotype Haplotypes - genetics Humans Linkage Disequilibrium Male Polymorphism, Single Nucleotide Receptors, GABA-A - genetics Schizophrenia - ethnology Schizophrenia - genetics Transmission disequilibrium |
| title | Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population |
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