Reduced Immunoregulatory CD31+ T Cells in the Blood of Atherosclerotic Mice With Plaque Thrombosis
OBJECTIVE—Lymphocyte activation is thought to play a major role in the pathogenesis of atherosclerotic complications such as plaque thrombosis. Circulating CD31 T cells have been shown to regulate human T cell activation. Aim of this study was to evaluate whether the proportion of circulating immuno...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2005-08, Vol.25 (8), p.1659-1664 |
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| creator | Caligiuri, Giuseppina Groyer, Emilie Khallou-Laschet, Jamila Zen, Ayman Al Haj Sainz, Julie Urbain, Dominique Gaston, Anh-Thu Lemitre, Mathilde Nicoletti, Antonino Lafont, Antoine |
| description | OBJECTIVE—Lymphocyte activation is thought to play a major role in the pathogenesis of atherosclerotic complications such as plaque thrombosis. Circulating CD31 T cells have been shown to regulate human T cell activation. Aim of this study was to evaluate whether the proportion of circulating immunoregulatory CD31 T cells is correlated to the occurrence of plaque thrombosis in aged apolipoprotein (apo) E knockout (KO) mice.
METHODS AND RESULTS—CD31 T cell depletion of spleen T cells enhanced proliferation (P |
| doi_str_mv | 10.1161/01.ATV.0000172660.24580.b4 |
| format | Article |
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METHODS AND RESULTS—CD31 T cell depletion of spleen T cells enhanced proliferation (P<0.05) and interferon-γ production (P<0.01) while reducing interleukin (IL)-4 (P<0.001) and IL-10 (P=0.001) secretion in response to minimally modified low-density lipoprotein. CD31 T cells were counted in 65 apoE KO mice (46-week-old) by flow cytometry. Organizing thrombi could be documented in 28 of 195 (14%) lesions and in at least one of the aorta root lesions in 23 of 65 mice (35%). CD31 T cell count was significantly reduced in mice showing plaque thrombosis (72.3±1.5% versus 84.1±1.2%; P<0.0001), but such reduction did not follow induced plaque rupture or experimentally controlled thrombosis.
CONCLUSIONS—Reduced CD31 T cells in circulating blood is a hallmark of atherosclerotic plaque thrombosis. Our data suggest that CD31 T cells may play an important regulatory role in the development of plaque thrombosis.</description><identifier>ISSN: 1079-5642</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/01.ATV.0000172660.24580.b4</identifier><identifier>PMID: 15933243</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Animals ; Apolipoproteins E - genetics ; Atherosclerosis (general aspects, experimental research) ; Atherosclerosis - immunology ; Atherosclerosis - pathology ; Biological and medical sciences ; Biomarkers ; Blood and lymphatic vessels ; Blood vessels and receptors ; Blood. Blood coagulation. Reticuloendothelial system ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Lymphocyte Activation - immunology ; Lymphocyte Count ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Pharmacology. Drug treatments ; Platelet Endothelial Cell Adhesion Molecule-1 - metabolism ; Rupture ; T-Lymphocytes - cytology ; T-Lymphocytes - immunology ; T-Lymphocytes - metabolism ; Thrombosis - immunology ; Thrombosis - pathology ; Vertebrates: cardiovascular system</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2005-08, Vol.25 (8), p.1659-1664</ispartof><rights>2005 American Heart Association, Inc.</rights><rights>2005 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Aug 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5054-efa22e111df81127b1bc385f77c5cdf37d487615305cc0ef461df886f6ef1d23</citedby><cites>FETCH-LOGICAL-c5054-efa22e111df81127b1bc385f77c5cdf37d487615305cc0ef461df886f6ef1d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17028952$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15933243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caligiuri, Giuseppina</creatorcontrib><creatorcontrib>Groyer, Emilie</creatorcontrib><creatorcontrib>Khallou-Laschet, Jamila</creatorcontrib><creatorcontrib>Zen, Ayman Al Haj</creatorcontrib><creatorcontrib>Sainz, Julie</creatorcontrib><creatorcontrib>Urbain, Dominique</creatorcontrib><creatorcontrib>Gaston, Anh-Thu</creatorcontrib><creatorcontrib>Lemitre, Mathilde</creatorcontrib><creatorcontrib>Nicoletti, Antonino</creatorcontrib><creatorcontrib>Lafont, Antoine</creatorcontrib><title>Reduced Immunoregulatory CD31+ T Cells in the Blood of Atherosclerotic Mice With Plaque Thrombosis</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—Lymphocyte activation is thought to play a major role in the pathogenesis of atherosclerotic complications such as plaque thrombosis. Circulating CD31 T cells have been shown to regulate human T cell activation. Aim of this study was to evaluate whether the proportion of circulating immunoregulatory CD31 T cells is correlated to the occurrence of plaque thrombosis in aged apolipoprotein (apo) E knockout (KO) mice.
METHODS AND RESULTS—CD31 T cell depletion of spleen T cells enhanced proliferation (P<0.05) and interferon-γ production (P<0.01) while reducing interleukin (IL)-4 (P<0.001) and IL-10 (P=0.001) secretion in response to minimally modified low-density lipoprotein. CD31 T cells were counted in 65 apoE KO mice (46-week-old) by flow cytometry. Organizing thrombi could be documented in 28 of 195 (14%) lesions and in at least one of the aorta root lesions in 23 of 65 mice (35%). CD31 T cell count was significantly reduced in mice showing plaque thrombosis (72.3±1.5% versus 84.1±1.2%; P<0.0001), but such reduction did not follow induced plaque rupture or experimentally controlled thrombosis.
CONCLUSIONS—Reduced CD31 T cells in circulating blood is a hallmark of atherosclerotic plaque thrombosis. Our data suggest that CD31 T cells may play an important regulatory role in the development of plaque thrombosis.</description><subject>Animals</subject><subject>Apolipoproteins E - genetics</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Atherosclerosis - immunology</subject><subject>Atherosclerosis - pathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood and lymphatic vessels</subject><subject>Blood vessels and receptors</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Lymphocyte Activation - immunology</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Pharmacology. Drug treatments</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - metabolism</subject><subject>Rupture</subject><subject>T-Lymphocytes - cytology</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><subject>Thrombosis - immunology</subject><subject>Thrombosis - pathology</subject><subject>Vertebrates: cardiovascular system</subject><issn>1079-5642</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkW1r1TAUx4sobk6_goSBvpF2OXns9d31qttgQ5GiL0OaJrYzbbakZezbm3ovXDCQhwO_nP85518U54ArAAEXGKpt87PCeYEkQuCKMF7jqmXPilPghJVMUPE8v7HclFwwclK8Suku84wQ_LI4Ab6hlDB6WrQ_bLcY26HrcVymEO3vxes5xCe0-0zhA2rQznqf0DChubfokw-hQ8GhbY5iSMbncx4Muh2MRb-GuUffvX5YLGr6GMY2pCG9Ll447ZN9c7jPiubrl2Z3Vd58u7zebW9KwzFnpXWaEAsAnasBiGyhNbTmTkrDTeeo7FgtBXCKuTHYOiZWshZOWAcdoWfF-33a-xhyAWlW45BMLl5PNixJiZoRLinL4Pl_4F1Y4pRLUwQzSvLURIY-7iGTu0zROnUfh1HHJwVYrS4oDCq7oI4uqH8uqHZVeHtQWNrRdsevh7Fn4N0B0Mlo76KezJCOnMSk3vC1J7bnHoOfbUx__PJoo-qt9nO_SjMqMC8JxhzXOSzzzvn_AjgNnqw</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Caligiuri, Giuseppina</creator><creator>Groyer, Emilie</creator><creator>Khallou-Laschet, Jamila</creator><creator>Zen, Ayman Al Haj</creator><creator>Sainz, Julie</creator><creator>Urbain, Dominique</creator><creator>Gaston, Anh-Thu</creator><creator>Lemitre, Mathilde</creator><creator>Nicoletti, Antonino</creator><creator>Lafont, Antoine</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>Reduced Immunoregulatory CD31+ T Cells in the Blood of Atherosclerotic Mice With Plaque Thrombosis</title><author>Caligiuri, Giuseppina ; Groyer, Emilie ; Khallou-Laschet, Jamila ; Zen, Ayman Al Haj ; Sainz, Julie ; Urbain, Dominique ; Gaston, Anh-Thu ; Lemitre, Mathilde ; Nicoletti, Antonino ; Lafont, Antoine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5054-efa22e111df81127b1bc385f77c5cdf37d487615305cc0ef461df886f6ef1d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Apolipoproteins E - genetics</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Atherosclerosis - immunology</topic><topic>Atherosclerosis - pathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood and lymphatic vessels</topic><topic>Blood vessels and receptors</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>Lymphocyte Activation - immunology</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Pharmacology. Drug treatments</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - metabolism</topic><topic>Rupture</topic><topic>T-Lymphocytes - cytology</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><topic>Thrombosis - immunology</topic><topic>Thrombosis - pathology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caligiuri, Giuseppina</creatorcontrib><creatorcontrib>Groyer, Emilie</creatorcontrib><creatorcontrib>Khallou-Laschet, Jamila</creatorcontrib><creatorcontrib>Zen, Ayman Al Haj</creatorcontrib><creatorcontrib>Sainz, Julie</creatorcontrib><creatorcontrib>Urbain, Dominique</creatorcontrib><creatorcontrib>Gaston, Anh-Thu</creatorcontrib><creatorcontrib>Lemitre, Mathilde</creatorcontrib><creatorcontrib>Nicoletti, Antonino</creatorcontrib><creatorcontrib>Lafont, Antoine</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caligiuri, Giuseppina</au><au>Groyer, Emilie</au><au>Khallou-Laschet, Jamila</au><au>Zen, Ayman Al Haj</au><au>Sainz, Julie</au><au>Urbain, Dominique</au><au>Gaston, Anh-Thu</au><au>Lemitre, Mathilde</au><au>Nicoletti, Antonino</au><au>Lafont, Antoine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Immunoregulatory CD31+ T Cells in the Blood of Atherosclerotic Mice With Plaque Thrombosis</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2005-08</date><risdate>2005</risdate><volume>25</volume><issue>8</issue><spage>1659</spage><epage>1664</epage><pages>1659-1664</pages><issn>1079-5642</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>OBJECTIVE—Lymphocyte activation is thought to play a major role in the pathogenesis of atherosclerotic complications such as plaque thrombosis. Circulating CD31 T cells have been shown to regulate human T cell activation. Aim of this study was to evaluate whether the proportion of circulating immunoregulatory CD31 T cells is correlated to the occurrence of plaque thrombosis in aged apolipoprotein (apo) E knockout (KO) mice.
METHODS AND RESULTS—CD31 T cell depletion of spleen T cells enhanced proliferation (P<0.05) and interferon-γ production (P<0.01) while reducing interleukin (IL)-4 (P<0.001) and IL-10 (P=0.001) secretion in response to minimally modified low-density lipoprotein. CD31 T cells were counted in 65 apoE KO mice (46-week-old) by flow cytometry. Organizing thrombi could be documented in 28 of 195 (14%) lesions and in at least one of the aorta root lesions in 23 of 65 mice (35%). CD31 T cell count was significantly reduced in mice showing plaque thrombosis (72.3±1.5% versus 84.1±1.2%; P<0.0001), but such reduction did not follow induced plaque rupture or experimentally controlled thrombosis.
CONCLUSIONS—Reduced CD31 T cells in circulating blood is a hallmark of atherosclerotic plaque thrombosis. Our data suggest that CD31 T cells may play an important regulatory role in the development of plaque thrombosis.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>15933243</pmid><doi>10.1161/01.ATV.0000172660.24580.b4</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arteriosclerosis, thrombosis, and vascular biology, 2005-08, Vol.25 (8), p.1659-1664 |
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| source | MEDLINE; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Animals Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Atherosclerosis - immunology Atherosclerosis - pathology Biological and medical sciences Biomarkers Blood and lymphatic vessels Blood vessels and receptors Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Lymphocyte Activation - immunology Lymphocyte Count Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Pharmacology. Drug treatments Platelet Endothelial Cell Adhesion Molecule-1 - metabolism Rupture T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Thrombosis - immunology Thrombosis - pathology Vertebrates: cardiovascular system |
| title | Reduced Immunoregulatory CD31+ T Cells in the Blood of Atherosclerotic Mice With Plaque Thrombosis |
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