Long-Term Effects of Feeding Monensin on Milk Fatty Acid Composition in Lactating Dairy Cows

The objective of this study was to determine the long-term effects of feeding monensin on milk fatty acid (FA) profile in lactating dairy cows. Twenty-four lactating Holstein dairy cows (1.46±0.17 parity; 620±5.9kg of live weight; 92.5±2.62 d in milk) housed in a tie-stall facility were used in the...

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Veröffentlicht in:Journal of dairy science 2007-11, Vol.90 (11), p.5126-5133
Hauptverfasser: Odongo, N.E., Or-Rashid, M.M., Bagg, R., Vessie, G., Dick, P., Kebreab, E., France, J., McBride, B.W.
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container_end_page 5133
container_issue 11
container_start_page 5126
container_title Journal of dairy science
container_volume 90
creator Odongo, N.E.
Or-Rashid, M.M.
Bagg, R.
Vessie, G.
Dick, P.
Kebreab, E.
France, J.
McBride, B.W.
description The objective of this study was to determine the long-term effects of feeding monensin on milk fatty acid (FA) profile in lactating dairy cows. Twenty-four lactating Holstein dairy cows (1.46±0.17 parity; 620±5.9kg of live weight; 92.5±2.62 d in milk) housed in a tie-stall facility were used in the study. The study was conducted as paired comparisons in a completely randomized block design with repeated measurements in a color-coded, double blind experiment. The cows were paired by parity and days in milk and allocated to 1 of 2 treatments: 1) the regular milking cow total mixed ration (TMR) with a forage-to-concentrate ratio of 60:40 (control TMR; placebo premix) vs. a medicated TMR [monensin TMR; regular TMR + 24mg of Rumensin Premix per kg of dry matter (DM)] fed ad libitum. The animals were fed and milked twice daily (feeding at 0830 and 1300h; milking at 0500 and 1500h). Milk samples were collected before the introduction of treatments and monthly thereafter for 6 mo and analyzed for FA composition. Monensin reduced the percentage of the short-and medium-chain saturated FA 7:0, 9:0, 15:0, and 16:0 in milk fat by 26, 35, 19, and 6%, respectively, compared with the control group. Monensin increased the percentage of the long-chain saturated FA in milk fat by 9%, total monounsaturated FA by 5%, total n-6 polyunsaturated FA (PUFA) by 19%, total n-3 PUFA by 16%, total cis-18:1 by 7%, and total conjugated linoleic acid (CLA) by 43% compared with the control group. Monensin increased the percentage of docosahexaenoic acid (22:6n-3), docosapentaenoic acid (22:5n-3), and cis-9, trans-11 CLA in milk fat by 19, 13, and 43%, respectively, compared with the control. These results suggest that monensin was at least partly effective in inhibiting the biohydrogenation of unsaturated FA in the rumen and consequently increased the percentage of n-6 and n-3 PUFA and CLA in milk, thus enhancing the nutritional properties of milk with regard to human health.
doi_str_mv 10.3168/jds.2007-0242
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Twenty-four lactating Holstein dairy cows (1.46±0.17 parity; 620±5.9kg of live weight; 92.5±2.62 d in milk) housed in a tie-stall facility were used in the study. The study was conducted as paired comparisons in a completely randomized block design with repeated measurements in a color-coded, double blind experiment. The cows were paired by parity and days in milk and allocated to 1 of 2 treatments: 1) the regular milking cow total mixed ration (TMR) with a forage-to-concentrate ratio of 60:40 (control TMR; placebo premix) vs. a medicated TMR [monensin TMR; regular TMR + 24mg of Rumensin Premix per kg of dry matter (DM)] fed ad libitum. The animals were fed and milked twice daily (feeding at 0830 and 1300h; milking at 0500 and 1500h). Milk samples were collected before the introduction of treatments and monthly thereafter for 6 mo and analyzed for FA composition. Monensin reduced the percentage of the short-and medium-chain saturated FA 7:0, 9:0, 15:0, and 16:0 in milk fat by 26, 35, 19, and 6%, respectively, compared with the control group. Monensin increased the percentage of the long-chain saturated FA in milk fat by 9%, total monounsaturated FA by 5%, total n-6 polyunsaturated FA (PUFA) by 19%, total n-3 PUFA by 16%, total cis-18:1 by 7%, and total conjugated linoleic acid (CLA) by 43% compared with the control group. Monensin increased the percentage of docosahexaenoic acid (22:6n-3), docosapentaenoic acid (22:5n-3), and cis-9, trans-11 CLA in milk fat by 19, 13, and 43%, respectively, compared with the control. 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Psychology ; Ionophores - administration &amp; dosage ; Ionophores - pharmacology ; Isomerism ; lactation ; Lactation - drug effects ; Lactation - physiology ; Linoleic Acids, Conjugated - analysis ; long chain fatty acids ; long term experiments ; medicated feeds ; Milk - chemistry ; Milk and cheese industries. Ice creams ; milk composition ; milk fat ; milk fatty acid composition ; monensin ; Monensin - administration &amp; dosage ; Monensin - pharmacology ; monounsaturated fatty acids ; nutritive value ; omega-3 fatty acids ; omega-6 fatty acids ; saturated fatty acids ; short chain fatty acids ; Terrestrial animal productions ; Time Factors ; Vertebrates</subject><ispartof>Journal of dairy science, 2007-11, Vol.90 (11), p.5126-5133</ispartof><rights>2007 American Dairy Science Association</rights><rights>2007 INIST-CNRS</rights><rights>Copyright American Dairy Science Association Nov 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-7f4a328f49f3f50f416f58f18051bc1ed332243590b9c8df7c51033db5972d803</citedby><cites>FETCH-LOGICAL-c491t-7f4a328f49f3f50f416f58f18051bc1ed332243590b9c8df7c51033db5972d803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.2007-0242$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=19204125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17954753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Odongo, N.E.</creatorcontrib><creatorcontrib>Or-Rashid, M.M.</creatorcontrib><creatorcontrib>Bagg, R.</creatorcontrib><creatorcontrib>Vessie, G.</creatorcontrib><creatorcontrib>Dick, P.</creatorcontrib><creatorcontrib>Kebreab, E.</creatorcontrib><creatorcontrib>France, J.</creatorcontrib><creatorcontrib>McBride, B.W.</creatorcontrib><title>Long-Term Effects of Feeding Monensin on Milk Fatty Acid Composition in Lactating Dairy Cows</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>The objective of this study was to determine the long-term effects of feeding monensin on milk fatty acid (FA) profile in lactating dairy cows. Twenty-four lactating Holstein dairy cows (1.46±0.17 parity; 620±5.9kg of live weight; 92.5±2.62 d in milk) housed in a tie-stall facility were used in the study. The study was conducted as paired comparisons in a completely randomized block design with repeated measurements in a color-coded, double blind experiment. The cows were paired by parity and days in milk and allocated to 1 of 2 treatments: 1) the regular milking cow total mixed ration (TMR) with a forage-to-concentrate ratio of 60:40 (control TMR; placebo premix) vs. a medicated TMR [monensin TMR; regular TMR + 24mg of Rumensin Premix per kg of dry matter (DM)] fed ad libitum. The animals were fed and milked twice daily (feeding at 0830 and 1300h; milking at 0500 and 1500h). Milk samples were collected before the introduction of treatments and monthly thereafter for 6 mo and analyzed for FA composition. Monensin reduced the percentage of the short-and medium-chain saturated FA 7:0, 9:0, 15:0, and 16:0 in milk fat by 26, 35, 19, and 6%, respectively, compared with the control group. Monensin increased the percentage of the long-chain saturated FA in milk fat by 9%, total monounsaturated FA by 5%, total n-6 polyunsaturated FA (PUFA) by 19%, total n-3 PUFA by 16%, total cis-18:1 by 7%, and total conjugated linoleic acid (CLA) by 43% compared with the control group. Monensin increased the percentage of docosahexaenoic acid (22:6n-3), docosapentaenoic acid (22:5n-3), and cis-9, trans-11 CLA in milk fat by 19, 13, and 43%, respectively, compared with the control. 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Psychology</subject><subject>Ionophores - administration &amp; dosage</subject><subject>Ionophores - pharmacology</subject><subject>Isomerism</subject><subject>lactation</subject><subject>Lactation - drug effects</subject><subject>Lactation - physiology</subject><subject>Linoleic Acids, Conjugated - analysis</subject><subject>long chain fatty acids</subject><subject>long term experiments</subject><subject>medicated feeds</subject><subject>Milk - chemistry</subject><subject>Milk and cheese industries. 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Twenty-four lactating Holstein dairy cows (1.46±0.17 parity; 620±5.9kg of live weight; 92.5±2.62 d in milk) housed in a tie-stall facility were used in the study. The study was conducted as paired comparisons in a completely randomized block design with repeated measurements in a color-coded, double blind experiment. The cows were paired by parity and days in milk and allocated to 1 of 2 treatments: 1) the regular milking cow total mixed ration (TMR) with a forage-to-concentrate ratio of 60:40 (control TMR; placebo premix) vs. a medicated TMR [monensin TMR; regular TMR + 24mg of Rumensin Premix per kg of dry matter (DM)] fed ad libitum. The animals were fed and milked twice daily (feeding at 0830 and 1300h; milking at 0500 and 1500h). Milk samples were collected before the introduction of treatments and monthly thereafter for 6 mo and analyzed for FA composition. 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These results suggest that monensin was at least partly effective in inhibiting the biohydrogenation of unsaturated FA in the rumen and consequently increased the percentage of n-6 and n-3 PUFA and CLA in milk, thus enhancing the nutritional properties of milk with regard to human health.</abstract><cop>Savoy, IL</cop><pub>Elsevier Inc</pub><pmid>17954753</pmid><doi>10.3168/jds.2007-0242</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Animal productions
Animals
Biological and medical sciences
Cattle - physiology
conjugated linoleic acid
dairy cow
dairy cows
docosahexaenoic acid
docosapentaenoic acid
dosage
Fats - analysis
Fats - chemistry
fatty acid composition
Fatty Acids - analysis
feed concentrates
feed rations
Female
Food industries
Fundamental and applied biological sciences. Psychology
Ionophores - administration & dosage
Ionophores - pharmacology
Isomerism
lactation
Lactation - drug effects
Lactation - physiology
Linoleic Acids, Conjugated - analysis
long chain fatty acids
long term experiments
medicated feeds
Milk - chemistry
Milk and cheese industries. Ice creams
milk composition
milk fat
milk fatty acid composition
monensin
Monensin - administration & dosage
Monensin - pharmacology
monounsaturated fatty acids
nutritive value
omega-3 fatty acids
omega-6 fatty acids
saturated fatty acids
short chain fatty acids
Terrestrial animal productions
Time Factors
Vertebrates
title Long-Term Effects of Feeding Monensin on Milk Fatty Acid Composition in Lactating Dairy Cows
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