Parametric study of a 6-column countercurrent solvent gradient purification (MCSGP) unit

The novel "multicolumn countercurrent solvent gradient purification" (MCSGP) process has been modeled for the purification of a polypeptide mixture characterized by a strong non-linear competitive adsorption isotherm. As a model system, the purification of an industrial polypeptide mixture...

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Veröffentlicht in:	Biotechnology and bioengineering 2007-12, Vol.98 (5), p.1029-1042
Hauptverfasser:	Aumann, Lars, Stroehlein, Guido, Morbidelli, Massimo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Algorithms Biological and medical sciences Biotechnology Biotechnology - methods Calcitonin - isolation & purification chromatographic modeling Computer Simulation continuous countercurrent solvent gradient Countercurrent Distribution - methods Fundamental and applied biological sciences. Psychology Hormones Kinetics MCSGP Methods. Procedures. Technologies Models, Theoretical multicomponent competitive bi-Langmuir isotherm Others peptide purification Peptides Peptides - isolation & purification Rheology Simulation SMB Solvents Temperature Various methods and equipments
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