Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment
The cortex of Mimosa tenuiflora is a popular remedy utilized in Mexico for the treatment of skin lesions. Modern studies support the existence in this cortex of compounds with cicatrizing properties. In the present study the therapeutic effectiveness of an extract elaborated with this bark in the tr...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 2007-02, Vol.109 (3), p.523-528 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 528 |
|---|---|
| container_issue | 3 |
| container_start_page | 523 |
| container_title | Journal of ethnopharmacology |
| container_volume | 109 |
| creator | Rivera-Arce, Erika Chávez-Soto, Marco Antonio Herrera-Arellano, Armando Arzate, Silvia Agüero, Juan Feria-Romero, Iris Angélica Cruz-Guzmán, Angélica Lozoya, Xavier |
| description | The cortex of
Mimosa tenuiflora is a popular remedy utilized in Mexico for the treatment of skin lesions. Modern studies support the existence in this cortex of compounds with cicatrizing properties. In the present study the therapeutic effectiveness of an extract elaborated with this bark in the treatment of venous leg ulceration disease was explored. A randomized, double-blind, placebo-controlled clinical trial was conducted with ambulatory patients distributed into two groups, one receiving a hydrogel containing 5% of a crude extract standardized in its tannin concentration (1.8%), while the control group, was administered the same hydrogel but without addition of the extract. In both aseptic washings were performed initially followed by topical application of the corresponding hydrogel and dressing. Follow-up lasted 13 weeks and ulcer healing was determined through measurement of the lesion area by digital-photographic parameters. Therapeutic effectiveness occurred in all patients of the extract group; after the 8th treatment week, ulcer size was reduced by 92% as mean value in this group, whereas therapeutic effectiveness was observed only in one patient of the control group (
χ
2,
p
=
0.0001). No side effects were observed in any patient in either group. |
| doi_str_mv | 10.1016/j.jep.2006.08.032 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68424467</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874106004272</els_id><sourcerecordid>68424467</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-45dc73b588f6ef88801b997a09b0caa81f4921cf5f64ef2d7d5769e7a69b2c893</originalsourceid><addsrcrecordid>eNp9kU1v1DAURS0EosPAD2AD3sAu4TlxYkesUMWXVMSCdm29OM_FoyQebKcq_x5XM1J3rN7mvKurcxl7LaAWIPoPh_pAx7oB6GvQNbTNE7YTWjWV6lT7lO2gVbrSSooL9iKlAwAoIeE5uxAKtIa237Hx-jdFPNKWveXkHNns72illHhwHPkPv4SEPNO6eTeHiNyGmOme032OaDP3Ky982BKf6ZZvsy1x2YeV50iYF1rzS_bM4Zzo1fnu2c2Xz9eX36qrn1-_X366qqyELleym6xqx05r15PTpZ8Yh0EhDCNYRC2cHBphXed6Sa6Z1NSpfiCF_TA2Vg_tnr0_5R5j-LNRymbxydI840qln-m1bKTsVQHFCbQxpBTJmWP0C8a_RoB5EGsOpog1D2INaFPElp835_BtXGh6_DibLMC7M4DJ4uwirtanR07LVnaF3LO3J85hMHgbC3PzqwHRlnG6spUsxMcTQUXWnadokvW0Wpp8LPOYKfj_FP0HMUygog</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68424467</pqid></control><display><type>article</type><title>Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Rivera-Arce, Erika ; Chávez-Soto, Marco Antonio ; Herrera-Arellano, Armando ; Arzate, Silvia ; Agüero, Juan ; Feria-Romero, Iris Angélica ; Cruz-Guzmán, Angélica ; Lozoya, Xavier</creator><creatorcontrib>Rivera-Arce, Erika ; Chávez-Soto, Marco Antonio ; Herrera-Arellano, Armando ; Arzate, Silvia ; Agüero, Juan ; Feria-Romero, Iris Angélica ; Cruz-Guzmán, Angélica ; Lozoya, Xavier</creatorcontrib><description>The cortex of
Mimosa tenuiflora is a popular remedy utilized in Mexico for the treatment of skin lesions. Modern studies support the existence in this cortex of compounds with cicatrizing properties. In the present study the therapeutic effectiveness of an extract elaborated with this bark in the treatment of venous leg ulceration disease was explored. A randomized, double-blind, placebo-controlled clinical trial was conducted with ambulatory patients distributed into two groups, one receiving a hydrogel containing 5% of a crude extract standardized in its tannin concentration (1.8%), while the control group, was administered the same hydrogel but without addition of the extract. In both aseptic washings were performed initially followed by topical application of the corresponding hydrogel and dressing. Follow-up lasted 13 weeks and ulcer healing was determined through measurement of the lesion area by digital-photographic parameters. Therapeutic effectiveness occurred in all patients of the extract group; after the 8th treatment week, ulcer size was reduced by 92% as mean value in this group, whereas therapeutic effectiveness was observed only in one patient of the control group (
χ
2,
p
=
0.0001). No side effects were observed in any patient in either group.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2006.08.032</identifier><identifier>PMID: 17088036</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; bark ; Biological and medical sciences ; blood circulation ; blood veins ; chemical constituents of plants ; Complementary and alternative medicine ; Double-Blind Method ; ethnobotany ; Female ; General pharmacology ; hematologic diseases ; herbal medicines ; Humans ; Leg Ulcer - drug therapy ; legs ; lesions (animal) ; Male ; Medical sciences ; medicinal plants ; medicinal properties ; Middle Aged ; Mimosa ; Mimosa - chemistry ; Mimosa tenuiflora ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytomedicine ; Phytotherapy ; plant extracts ; Plant Extracts - therapeutic use ; skin diseases ; traditional medicine ; Treatment Outcome ; Venous leg ulceration disease</subject><ispartof>Journal of ethnopharmacology, 2007-02, Vol.109 (3), p.523-528</ispartof><rights>2006 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-45dc73b588f6ef88801b997a09b0caa81f4921cf5f64ef2d7d5769e7a69b2c893</citedby><cites>FETCH-LOGICAL-c405t-45dc73b588f6ef88801b997a09b0caa81f4921cf5f64ef2d7d5769e7a69b2c893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2006.08.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18434580$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17088036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rivera-Arce, Erika</creatorcontrib><creatorcontrib>Chávez-Soto, Marco Antonio</creatorcontrib><creatorcontrib>Herrera-Arellano, Armando</creatorcontrib><creatorcontrib>Arzate, Silvia</creatorcontrib><creatorcontrib>Agüero, Juan</creatorcontrib><creatorcontrib>Feria-Romero, Iris Angélica</creatorcontrib><creatorcontrib>Cruz-Guzmán, Angélica</creatorcontrib><creatorcontrib>Lozoya, Xavier</creatorcontrib><title>Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The cortex of
Mimosa tenuiflora is a popular remedy utilized in Mexico for the treatment of skin lesions. Modern studies support the existence in this cortex of compounds with cicatrizing properties. In the present study the therapeutic effectiveness of an extract elaborated with this bark in the treatment of venous leg ulceration disease was explored. A randomized, double-blind, placebo-controlled clinical trial was conducted with ambulatory patients distributed into two groups, one receiving a hydrogel containing 5% of a crude extract standardized in its tannin concentration (1.8%), while the control group, was administered the same hydrogel but without addition of the extract. In both aseptic washings were performed initially followed by topical application of the corresponding hydrogel and dressing. Follow-up lasted 13 weeks and ulcer healing was determined through measurement of the lesion area by digital-photographic parameters. Therapeutic effectiveness occurred in all patients of the extract group; after the 8th treatment week, ulcer size was reduced by 92% as mean value in this group, whereas therapeutic effectiveness was observed only in one patient of the control group (
χ
2,
p
=
0.0001). No side effects were observed in any patient in either group.</description><subject>Adult</subject><subject>Aged</subject><subject>bark</subject><subject>Biological and medical sciences</subject><subject>blood circulation</subject><subject>blood veins</subject><subject>chemical constituents of plants</subject><subject>Complementary and alternative medicine</subject><subject>Double-Blind Method</subject><subject>ethnobotany</subject><subject>Female</subject><subject>General pharmacology</subject><subject>hematologic diseases</subject><subject>herbal medicines</subject><subject>Humans</subject><subject>Leg Ulcer - drug therapy</subject><subject>legs</subject><subject>lesions (animal)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>medicinal plants</subject><subject>medicinal properties</subject><subject>Middle Aged</subject><subject>Mimosa</subject><subject>Mimosa - chemistry</subject><subject>Mimosa tenuiflora</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytomedicine</subject><subject>Phytotherapy</subject><subject>plant extracts</subject><subject>Plant Extracts - therapeutic use</subject><subject>skin diseases</subject><subject>traditional medicine</subject><subject>Treatment Outcome</subject><subject>Venous leg ulceration disease</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAURS0EosPAD2AD3sAu4TlxYkesUMWXVMSCdm29OM_FoyQebKcq_x5XM1J3rN7mvKurcxl7LaAWIPoPh_pAx7oB6GvQNbTNE7YTWjWV6lT7lO2gVbrSSooL9iKlAwAoIeE5uxAKtIa237Hx-jdFPNKWveXkHNns72illHhwHPkPv4SEPNO6eTeHiNyGmOme032OaDP3Ky982BKf6ZZvsy1x2YeV50iYF1rzS_bM4Zzo1fnu2c2Xz9eX36qrn1-_X366qqyELleym6xqx05r15PTpZ8Yh0EhDCNYRC2cHBphXed6Sa6Z1NSpfiCF_TA2Vg_tnr0_5R5j-LNRymbxydI840qln-m1bKTsVQHFCbQxpBTJmWP0C8a_RoB5EGsOpog1D2INaFPElp835_BtXGh6_DibLMC7M4DJ4uwirtanR07LVnaF3LO3J85hMHgbC3PzqwHRlnG6spUsxMcTQUXWnadokvW0Wpp8LPOYKfj_FP0HMUygog</recordid><startdate>20070212</startdate><enddate>20070212</enddate><creator>Rivera-Arce, Erika</creator><creator>Chávez-Soto, Marco Antonio</creator><creator>Herrera-Arellano, Armando</creator><creator>Arzate, Silvia</creator><creator>Agüero, Juan</creator><creator>Feria-Romero, Iris Angélica</creator><creator>Cruz-Guzmán, Angélica</creator><creator>Lozoya, Xavier</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070212</creationdate><title>Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment</title><author>Rivera-Arce, Erika ; Chávez-Soto, Marco Antonio ; Herrera-Arellano, Armando ; Arzate, Silvia ; Agüero, Juan ; Feria-Romero, Iris Angélica ; Cruz-Guzmán, Angélica ; Lozoya, Xavier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-45dc73b588f6ef88801b997a09b0caa81f4921cf5f64ef2d7d5769e7a69b2c893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>bark</topic><topic>Biological and medical sciences</topic><topic>blood circulation</topic><topic>blood veins</topic><topic>chemical constituents of plants</topic><topic>Complementary and alternative medicine</topic><topic>Double-Blind Method</topic><topic>ethnobotany</topic><topic>Female</topic><topic>General pharmacology</topic><topic>hematologic diseases</topic><topic>herbal medicines</topic><topic>Humans</topic><topic>Leg Ulcer - drug therapy</topic><topic>legs</topic><topic>lesions (animal)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>medicinal plants</topic><topic>medicinal properties</topic><topic>Middle Aged</topic><topic>Mimosa</topic><topic>Mimosa - chemistry</topic><topic>Mimosa tenuiflora</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytomedicine</topic><topic>Phytotherapy</topic><topic>plant extracts</topic><topic>Plant Extracts - therapeutic use</topic><topic>skin diseases</topic><topic>traditional medicine</topic><topic>Treatment Outcome</topic><topic>Venous leg ulceration disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rivera-Arce, Erika</creatorcontrib><creatorcontrib>Chávez-Soto, Marco Antonio</creatorcontrib><creatorcontrib>Herrera-Arellano, Armando</creatorcontrib><creatorcontrib>Arzate, Silvia</creatorcontrib><creatorcontrib>Agüero, Juan</creatorcontrib><creatorcontrib>Feria-Romero, Iris Angélica</creatorcontrib><creatorcontrib>Cruz-Guzmán, Angélica</creatorcontrib><creatorcontrib>Lozoya, Xavier</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rivera-Arce, Erika</au><au>Chávez-Soto, Marco Antonio</au><au>Herrera-Arellano, Armando</au><au>Arzate, Silvia</au><au>Agüero, Juan</au><au>Feria-Romero, Iris Angélica</au><au>Cruz-Guzmán, Angélica</au><au>Lozoya, Xavier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2007-02-12</date><risdate>2007</risdate><volume>109</volume><issue>3</issue><spage>523</spage><epage>528</epage><pages>523-528</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The cortex of
Mimosa tenuiflora is a popular remedy utilized in Mexico for the treatment of skin lesions. Modern studies support the existence in this cortex of compounds with cicatrizing properties. In the present study the therapeutic effectiveness of an extract elaborated with this bark in the treatment of venous leg ulceration disease was explored. A randomized, double-blind, placebo-controlled clinical trial was conducted with ambulatory patients distributed into two groups, one receiving a hydrogel containing 5% of a crude extract standardized in its tannin concentration (1.8%), while the control group, was administered the same hydrogel but without addition of the extract. In both aseptic washings were performed initially followed by topical application of the corresponding hydrogel and dressing. Follow-up lasted 13 weeks and ulcer healing was determined through measurement of the lesion area by digital-photographic parameters. Therapeutic effectiveness occurred in all patients of the extract group; after the 8th treatment week, ulcer size was reduced by 92% as mean value in this group, whereas therapeutic effectiveness was observed only in one patient of the control group (
χ
2,
p
=
0.0001). No side effects were observed in any patient in either group.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>17088036</pmid><doi>10.1016/j.jep.2006.08.032</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2007-02, Vol.109 (3), p.523-528 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68424467 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Aged bark Biological and medical sciences blood circulation blood veins chemical constituents of plants Complementary and alternative medicine Double-Blind Method ethnobotany Female General pharmacology hematologic diseases herbal medicines Humans Leg Ulcer - drug therapy legs lesions (animal) Male Medical sciences medicinal plants medicinal properties Middle Aged Mimosa Mimosa - chemistry Mimosa tenuiflora Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytomedicine Phytotherapy plant extracts Plant Extracts - therapeutic use skin diseases traditional medicine Treatment Outcome Venous leg ulceration disease |
| title | Therapeutic effectiveness of a Mimosa tenuiflora cortex extract in venous leg ulceration treatment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T06%3A27%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Therapeutic%20effectiveness%20of%20a%20Mimosa%20tenuiflora%20cortex%20extract%20in%20venous%20leg%20ulceration%20treatment&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Rivera-Arce,%20Erika&rft.date=2007-02-12&rft.volume=109&rft.issue=3&rft.spage=523&rft.epage=528&rft.pages=523-528&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/j.jep.2006.08.032&rft_dat=%3Cproquest_cross%3E68424467%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68424467&rft_id=info:pmid/17088036&rft_els_id=S0378874106004272&rfr_iscdi=true |