The EORTC QLQ-HDC29: A supplementary module assessing the quality of life during and after high-dose chemotherapy and stem cell transplantation
Abstract High-dose chemotherapy followed by haematopoietic stem cell transplantation can be associated with high physical and emotional distress levels and reduced quality of life. Systematic prospective measurement of impact of therapy on patient quality of life can aid treatment choices and provid...
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| Veröffentlicht in: | European journal of cancer (1990) 2007-01, Vol.43 (1), p.87-94 |
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| container_title | European journal of cancer (1990) |
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| creator | Velikova, G Weis, J Hjermstad, M.J Kopp, M Morris, P Watson, M Sezer, O |
| description | Abstract High-dose chemotherapy followed by haematopoietic stem cell transplantation can be associated with high physical and emotional distress levels and reduced quality of life. Systematic prospective measurement of impact of therapy on patient quality of life can aid treatment choices and provide better patient information. We describe the development of a high-dose chemotherapy questionnaire module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30). Phases 1–3 of module development were conducted in United Kingdom, Germany, Austria and Norway, according to EORTC QOL Group guidelines. Forty-eight quality of life (QOL) issues were generated from the literature searches and interviews with health care professionals ( n = 24) and patients ( n = 92). This produced a 50 item provisional module. Further testing in 169 patients resulted in the QLQ-HDC29 module, containing 29 items, conceptualised into six multi-item scales and eight single items. The EORTC QLQ-C30, supplemented by QLQ-HDC29 will provide a comprehensive QOL measure for the international clinical trials of high-dose chemotherapy. |
| doi_str_mv | 10.1016/j.ejca.2006.09.004 |
| format | Article |
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Systematic prospective measurement of impact of therapy on patient quality of life can aid treatment choices and provide better patient information. We describe the development of a high-dose chemotherapy questionnaire module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30). Phases 1–3 of module development were conducted in United Kingdom, Germany, Austria and Norway, according to EORTC QOL Group guidelines. Forty-eight quality of life (QOL) issues were generated from the literature searches and interviews with health care professionals ( n = 24) and patients ( n = 92). This produced a 50 item provisional module. Further testing in 169 patients resulted in the QLQ-HDC29 module, containing 29 items, conceptualised into six multi-item scales and eight single items. The EORTC QLQ-C30, supplemented by QLQ-HDC29 will provide a comprehensive QOL measure for the international clinical trials of high-dose chemotherapy.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2006.09.004</identifier><identifier>PMID: 17081744</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Anxiety - etiology ; Attitude of Health Personnel ; Biological and medical sciences ; Cancer ; Combined Modality Therapy - psychology ; Female ; Health Status ; Hematology, Oncology and Palliative Medicine ; Hematopoietic Stem Cell Transplantation - psychology ; High-dose chemotherapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasms - drug therapy ; Neoplasms - psychology ; Oncology ; Patient Satisfaction ; Pharmacology. Drug treatments ; Quality of Life ; Statistics as Topic ; Stem cell transplantation ; Stress, Psychological - diagnosis ; Stress, Psychological - etiology ; Surveys and Questionnaires - standards ; Tumors</subject><ispartof>European journal of cancer (1990), 2007-01, Vol.43 (1), p.87-94</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-990174d6ebb2bc736f6aff4b87fea0d961e1017f9da09aca8a9d4a5819bdebb33</citedby><cites>FETCH-LOGICAL-c505t-990174d6ebb2bc736f6aff4b87fea0d961e1017f9da09aca8a9d4a5819bdebb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejca.2006.09.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18467106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17081744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velikova, G</creatorcontrib><creatorcontrib>Weis, J</creatorcontrib><creatorcontrib>Hjermstad, M.J</creatorcontrib><creatorcontrib>Kopp, M</creatorcontrib><creatorcontrib>Morris, P</creatorcontrib><creatorcontrib>Watson, M</creatorcontrib><creatorcontrib>Sezer, O</creatorcontrib><creatorcontrib>on behalf of the EORTC Quality of Life Group</creatorcontrib><creatorcontrib>EORTC Quality of Life Group</creatorcontrib><title>The EORTC QLQ-HDC29: A supplementary module assessing the quality of life during and after high-dose chemotherapy and stem cell transplantation</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Abstract High-dose chemotherapy followed by haematopoietic stem cell transplantation can be associated with high physical and emotional distress levels and reduced quality of life. Systematic prospective measurement of impact of therapy on patient quality of life can aid treatment choices and provide better patient information. We describe the development of a high-dose chemotherapy questionnaire module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30). Phases 1–3 of module development were conducted in United Kingdom, Germany, Austria and Norway, according to EORTC QOL Group guidelines. Forty-eight quality of life (QOL) issues were generated from the literature searches and interviews with health care professionals ( n = 24) and patients ( n = 92). This produced a 50 item provisional module. Further testing in 169 patients resulted in the QLQ-HDC29 module, containing 29 items, conceptualised into six multi-item scales and eight single items. The EORTC QLQ-C30, supplemented by QLQ-HDC29 will provide a comprehensive QOL measure for the international clinical trials of high-dose chemotherapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Anxiety - etiology</subject><subject>Attitude of Health Personnel</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Combined Modality Therapy - psychology</subject><subject>Female</subject><subject>Health Status</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hematopoietic Stem Cell Transplantation - psychology</subject><subject>High-dose chemotherapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - psychology</subject><subject>Oncology</subject><subject>Patient Satisfaction</subject><subject>Pharmacology. Drug treatments</subject><subject>Quality of Life</subject><subject>Statistics as Topic</subject><subject>Stem cell transplantation</subject><subject>Stress, Psychological - diagnosis</subject><subject>Stress, Psychological - etiology</subject><subject>Surveys and Questionnaires - standards</subject><subject>Tumors</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kk9v1DAQxSMEotvCF-CAfIFbwjjrTWKEKlXbQpFWqgrL2XLscddL_tWTIO2n4CvjsCtV4sDJB__ezNN7kyRvOGQcePFhn-He6CwHKDKQGYB4lix4VcoUqlX-PFmAXMm0AiHPknOiPQCUlYCXyRkvoeKlEIvk93aH7Obu23bN7jf36e31Opcf2RWjaRgabLEbdTiwtrdTg0wTIZHvHtgYVY-Tbvx4YL1jjXfI7BTmL91Zpt2Ige38wy61PSEzO2z7qAl6OPwFaMSWGWwaNgbd0dDouGj0ffcqeeF0Q_j69F4kPz7fbNe36ebuy9f11SY1K1iNqZQQ_dsC6zqvTbksXKGdE3VVOtRgZcExRlQ6aTVIbXSlpRV6VXFZ26hZLi-S98e5Q-gfJ6RRtZ5mQ7rDfiJVVCIXSy4imB9BE3qigE4NwbcxFMVBzTWovZprUHMNCqSKNUTR29P0qW7RPklOuUfg3QnQZHTjYgjG0xNXiaLkUETu05HDmMUvj0GR8dgZtD6gGZXt_f99XP4jN43vfNz4Ew9I-34KXUxZcUW5AvV9Ppj5XqCAaJTnyz9pdLyc</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Velikova, G</creator><creator>Weis, J</creator><creator>Hjermstad, M.J</creator><creator>Kopp, M</creator><creator>Morris, P</creator><creator>Watson, M</creator><creator>Sezer, O</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>The EORTC QLQ-HDC29: A supplementary module assessing the quality of life during and after high-dose chemotherapy and stem cell transplantation</title><author>Velikova, G ; Weis, J ; Hjermstad, M.J ; Kopp, M ; Morris, P ; Watson, M ; Sezer, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-990174d6ebb2bc736f6aff4b87fea0d961e1017f9da09aca8a9d4a5819bdebb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Anxiety - etiology</topic><topic>Attitude of Health Personnel</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Combined Modality Therapy - psychology</topic><topic>Female</topic><topic>Health Status</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hematopoietic Stem Cell Transplantation - psychology</topic><topic>High-dose chemotherapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - psychology</topic><topic>Oncology</topic><topic>Patient Satisfaction</topic><topic>Pharmacology. Drug treatments</topic><topic>Quality of Life</topic><topic>Statistics as Topic</topic><topic>Stem cell transplantation</topic><topic>Stress, Psychological - diagnosis</topic><topic>Stress, Psychological - etiology</topic><topic>Surveys and Questionnaires - standards</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velikova, G</creatorcontrib><creatorcontrib>Weis, J</creatorcontrib><creatorcontrib>Hjermstad, M.J</creatorcontrib><creatorcontrib>Kopp, M</creatorcontrib><creatorcontrib>Morris, P</creatorcontrib><creatorcontrib>Watson, M</creatorcontrib><creatorcontrib>Sezer, O</creatorcontrib><creatorcontrib>on behalf of the EORTC Quality of Life Group</creatorcontrib><creatorcontrib>EORTC Quality of Life Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velikova, G</au><au>Weis, J</au><au>Hjermstad, M.J</au><au>Kopp, M</au><au>Morris, P</au><au>Watson, M</au><au>Sezer, O</au><aucorp>on behalf of the EORTC Quality of Life Group</aucorp><aucorp>EORTC Quality of Life Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The EORTC QLQ-HDC29: A supplementary module assessing the quality of life during and after high-dose chemotherapy and stem cell transplantation</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>43</volume><issue>1</issue><spage>87</spage><epage>94</epage><pages>87-94</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Abstract High-dose chemotherapy followed by haematopoietic stem cell transplantation can be associated with high physical and emotional distress levels and reduced quality of life. Systematic prospective measurement of impact of therapy on patient quality of life can aid treatment choices and provide better patient information. We describe the development of a high-dose chemotherapy questionnaire module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30). Phases 1–3 of module development were conducted in United Kingdom, Germany, Austria and Norway, according to EORTC QOL Group guidelines. Forty-eight quality of life (QOL) issues were generated from the literature searches and interviews with health care professionals ( n = 24) and patients ( n = 92). This produced a 50 item provisional module. Further testing in 169 patients resulted in the QLQ-HDC29 module, containing 29 items, conceptualised into six multi-item scales and eight single items. 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| subjects | Adolescent Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use Anxiety - etiology Attitude of Health Personnel Biological and medical sciences Cancer Combined Modality Therapy - psychology Female Health Status Hematology, Oncology and Palliative Medicine Hematopoietic Stem Cell Transplantation - psychology High-dose chemotherapy Humans Male Medical sciences Middle Aged Neoplasms - drug therapy Neoplasms - psychology Oncology Patient Satisfaction Pharmacology. Drug treatments Quality of Life Statistics as Topic Stem cell transplantation Stress, Psychological - diagnosis Stress, Psychological - etiology Surveys and Questionnaires - standards Tumors |
| title | The EORTC QLQ-HDC29: A supplementary module assessing the quality of life during and after high-dose chemotherapy and stem cell transplantation |
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