Isogentisin—A novel compound for the prevention of smoking-caused endothelial injury
Abstract The best strategy in the fight against tobacco-induced diseases is prevention. However, more than one billion people around the world are smokers. Most of these people will develop or already suffer from tobacco-induced diseases. In this project, we screened 22 natural alpine plant extracts...
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| Veröffentlicht in: | Atherosclerosis 2007-10, Vol.194 (2), p.317-325 |
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| creator | Schmieder, Astrid Schwaiger, Stefan Csordas, Adam Backovic, Aleksandar Messner, Barbara Wick, Georg Stuppner, Hermann Bernhard, David |
| description | Abstract The best strategy in the fight against tobacco-induced diseases is prevention. However, more than one billion people around the world are smokers. Most of these people will develop or already suffer from tobacco-induced diseases. In this project, we screened 22 natural alpine plant extracts for their potential to protect human vascular endothelial cells from cigarette smoke-induced cell damage. Extracts from Gentiana lutea (Yellow Gentian) proved to be effective, and were therefore subjected to bio-guided fractionation. Although our analyses suggest that G. lutea contains several active principles, fractions containing isogentisin (1,3-dihydroxy-7-methoxyxanthone), and pure isogentisin, were most effective. In experiments addressing the nature of the mechanism of protection, we were able to show that isogentisin does not directly interfere with cigarette smoke chemicals. Addition of isogentisin to the cells as long as 4.5 h after exposure to cigarette smoke chemicals protected endothelial cells from cell death. Finally, detailed analyses of intracellular oxidative stress and protein oxidation suggest that isogentisin promotes cell survival by activating cellular repair functions. |
| doi_str_mv | 10.1016/j.atherosclerosis.2006.10.019 |
| format | Article |
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However, more than one billion people around the world are smokers. Most of these people will develop or already suffer from tobacco-induced diseases. In this project, we screened 22 natural alpine plant extracts for their potential to protect human vascular endothelial cells from cigarette smoke-induced cell damage. Extracts from Gentiana lutea (Yellow Gentian) proved to be effective, and were therefore subjected to bio-guided fractionation. Although our analyses suggest that G. lutea contains several active principles, fractions containing isogentisin (1,3-dihydroxy-7-methoxyxanthone), and pure isogentisin, were most effective. In experiments addressing the nature of the mechanism of protection, we were able to show that isogentisin does not directly interfere with cigarette smoke chemicals. Addition of isogentisin to the cells as long as 4.5 h after exposure to cigarette smoke chemicals protected endothelial cells from cell death. Finally, detailed analyses of intracellular oxidative stress and protein oxidation suggest that isogentisin promotes cell survival by activating cellular repair functions.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2006.10.019</identifier><identifier>PMID: 17141243</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ireland Ltd</publisher><subject>Antihypertensive agents ; Apoptosis ; Apoptosis - drug effects ; Atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Bio-guided ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood. Blood coagulation. Reticuloendothelial system ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular system ; Cells, Cultured ; Cigarette smoke extract ; Dysfunction ; Endothelial ; Endothelial Cells - drug effects ; Gentiana - chemistry ; Humans ; HUVECs ; Injury ; Isogentisin ; Medical sciences ; Microtubules - drug effects ; Necrosis ; Oxidative stress ; Oxidative Stress - drug effects ; Pharmacology. Drug treatments ; Phytochemistry ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Smoking - physiopathology ; Umbilical Veins - cytology ; Umbilical Veins - drug effects ; Xanthone ; Xanthones - chemistry ; Xanthones - pharmacology</subject><ispartof>Atherosclerosis, 2007-10, Vol.194 (2), p.317-325</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2006 Elsevier Ireland Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-2a9e10e83df0693a9585b9af0f0ef5c73ec78ff923fe5d2388d94fc236973c8b3</citedby><cites>FETCH-LOGICAL-c472t-2a9e10e83df0693a9585b9af0f0ef5c73ec78ff923fe5d2388d94fc236973c8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2006.10.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19172677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17141243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmieder, Astrid</creatorcontrib><creatorcontrib>Schwaiger, Stefan</creatorcontrib><creatorcontrib>Csordas, Adam</creatorcontrib><creatorcontrib>Backovic, Aleksandar</creatorcontrib><creatorcontrib>Messner, Barbara</creatorcontrib><creatorcontrib>Wick, Georg</creatorcontrib><creatorcontrib>Stuppner, Hermann</creatorcontrib><creatorcontrib>Bernhard, David</creatorcontrib><title>Isogentisin—A novel compound for the prevention of smoking-caused endothelial injury</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract The best strategy in the fight against tobacco-induced diseases is prevention. However, more than one billion people around the world are smokers. Most of these people will develop or already suffer from tobacco-induced diseases. In this project, we screened 22 natural alpine plant extracts for their potential to protect human vascular endothelial cells from cigarette smoke-induced cell damage. Extracts from Gentiana lutea (Yellow Gentian) proved to be effective, and were therefore subjected to bio-guided fractionation. Although our analyses suggest that G. lutea contains several active principles, fractions containing isogentisin (1,3-dihydroxy-7-methoxyxanthone), and pure isogentisin, were most effective. In experiments addressing the nature of the mechanism of protection, we were able to show that isogentisin does not directly interfere with cigarette smoke chemicals. Addition of isogentisin to the cells as long as 4.5 h after exposure to cigarette smoke chemicals protected endothelial cells from cell death. Finally, detailed analyses of intracellular oxidative stress and protein oxidation suggest that isogentisin promotes cell survival by activating cellular repair functions.</description><subject>Antihypertensive agents</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Bio-guided</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular system</subject><subject>Cells, Cultured</subject><subject>Cigarette smoke extract</subject><subject>Dysfunction</subject><subject>Endothelial</subject><subject>Endothelial Cells - drug effects</subject><subject>Gentiana - chemistry</subject><subject>Humans</subject><subject>HUVECs</subject><subject>Injury</subject><subject>Isogentisin</subject><subject>Medical sciences</subject><subject>Microtubules - drug effects</subject><subject>Necrosis</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytochemistry</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Roots - chemistry</subject><subject>Smoking - physiopathology</subject><subject>Umbilical Veins - cytology</subject><subject>Umbilical Veins - drug effects</subject><subject>Xanthone</subject><subject>Xanthones - chemistry</subject><subject>Xanthones - pharmacology</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-KFDEQh4Mo7rj6CtKX9dZjJenuJAeFZVnXhQUP_rmGTLqyprcnGZPugbn5ED6hT2KaGRT2JITkUF_VL3wUIRcU1hRo93ZYm-k7ppjtuNw-rxlAV2proOoJWVEpVE0b2TwlKwBGa0VbOCMvch4AoBFUPidnVNCGsoavyLfbHO8xTD778Pvnr8sqxD2OlY3bXZxDX7mYqpJX7RLuFyyGKroqb-ODD_e1NXPGvsLQxwKN3oyVD8OcDi_JM2fGjK9O7zn5-uH6y9XH-u7Tze3V5V1tG8GmmhmFFFDy3kGnuFGtbDfKOHCArrWCoxXSOcW4w7ZnXMpeNc4y3inBrdzwc_LmOHeX4o8Z86S3PlscRxMwzll3smGct20B3x1BW6TlhE7vkt-adNAU9CJWD_qRWL2IXcpFbOl_fQqaN1vs_3WfTBbg4gSYbM3okgm2zPjLKSpYJ0Thbo4cFi17j0ln6zFY7H1CO-k--v_-0vtHk-zogy_hD3jAPMQ5heJeU52ZBv152YZlGaArpwXG_wAamLfx</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Schmieder, Astrid</creator><creator>Schwaiger, Stefan</creator><creator>Csordas, Adam</creator><creator>Backovic, Aleksandar</creator><creator>Messner, Barbara</creator><creator>Wick, Georg</creator><creator>Stuppner, Hermann</creator><creator>Bernhard, David</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Isogentisin—A novel compound for the prevention of smoking-caused endothelial injury</title><author>Schmieder, Astrid ; Schwaiger, Stefan ; Csordas, Adam ; Backovic, Aleksandar ; Messner, Barbara ; Wick, Georg ; Stuppner, Hermann ; Bernhard, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-2a9e10e83df0693a9585b9af0f0ef5c73ec78ff923fe5d2388d94fc236973c8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antihypertensive agents</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>Atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Bio-guided</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular system</topic><topic>Cells, Cultured</topic><topic>Cigarette smoke extract</topic><topic>Dysfunction</topic><topic>Endothelial</topic><topic>Endothelial Cells - drug effects</topic><topic>Gentiana - chemistry</topic><topic>Humans</topic><topic>HUVECs</topic><topic>Injury</topic><topic>Isogentisin</topic><topic>Medical sciences</topic><topic>Microtubules - drug effects</topic><topic>Necrosis</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Phytochemistry</topic><topic>Phytotherapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Roots - chemistry</topic><topic>Smoking - physiopathology</topic><topic>Umbilical Veins - cytology</topic><topic>Umbilical Veins - drug effects</topic><topic>Xanthone</topic><topic>Xanthones - chemistry</topic><topic>Xanthones - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmieder, Astrid</creatorcontrib><creatorcontrib>Schwaiger, Stefan</creatorcontrib><creatorcontrib>Csordas, Adam</creatorcontrib><creatorcontrib>Backovic, Aleksandar</creatorcontrib><creatorcontrib>Messner, Barbara</creatorcontrib><creatorcontrib>Wick, Georg</creatorcontrib><creatorcontrib>Stuppner, Hermann</creatorcontrib><creatorcontrib>Bernhard, David</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmieder, Astrid</au><au>Schwaiger, Stefan</au><au>Csordas, Adam</au><au>Backovic, Aleksandar</au><au>Messner, Barbara</au><au>Wick, Georg</au><au>Stuppner, Hermann</au><au>Bernhard, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isogentisin—A novel compound for the prevention of smoking-caused endothelial injury</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>194</volume><issue>2</issue><spage>317</spage><epage>325</epage><pages>317-325</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract The best strategy in the fight against tobacco-induced diseases is prevention. However, more than one billion people around the world are smokers. Most of these people will develop or already suffer from tobacco-induced diseases. In this project, we screened 22 natural alpine plant extracts for their potential to protect human vascular endothelial cells from cigarette smoke-induced cell damage. Extracts from Gentiana lutea (Yellow Gentian) proved to be effective, and were therefore subjected to bio-guided fractionation. Although our analyses suggest that G. lutea contains several active principles, fractions containing isogentisin (1,3-dihydroxy-7-methoxyxanthone), and pure isogentisin, were most effective. In experiments addressing the nature of the mechanism of protection, we were able to show that isogentisin does not directly interfere with cigarette smoke chemicals. Addition of isogentisin to the cells as long as 4.5 h after exposure to cigarette smoke chemicals protected endothelial cells from cell death. Finally, detailed analyses of intracellular oxidative stress and protein oxidation suggest that isogentisin promotes cell survival by activating cellular repair functions.</abstract><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>17141243</pmid><doi>10.1016/j.atherosclerosis.2006.10.019</doi><tpages>9</tpages></addata></record> |
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| subjects | Antihypertensive agents Apoptosis Apoptosis - drug effects Atherosclerosis Atherosclerosis (general aspects, experimental research) Bio-guided Biological and medical sciences Blood and lymphatic vessels Blood. Blood coagulation. Reticuloendothelial system Cardiology. Vascular system Cardiovascular Cardiovascular system Cells, Cultured Cigarette smoke extract Dysfunction Endothelial Endothelial Cells - drug effects Gentiana - chemistry Humans HUVECs Injury Isogentisin Medical sciences Microtubules - drug effects Necrosis Oxidative stress Oxidative Stress - drug effects Pharmacology. Drug treatments Phytochemistry Phytotherapy Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Smoking - physiopathology Umbilical Veins - cytology Umbilical Veins - drug effects Xanthone Xanthones - chemistry Xanthones - pharmacology |
| title | Isogentisin—A novel compound for the prevention of smoking-caused endothelial injury |
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