Total Synthesis of Myxovirescin A1

A convergent total synthesis of the antibiotic macrolide myxovirescin A1 (1) is described that is largely based on reagent‐ and catalyst‐controlled transformations. This includes a highly regioselective Negishi reaction of dibromo‐alkene 48 with an alkynylzinc reagent, and a palladium catalyzed alky...

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Veröffentlicht in:	Chemistry : a European journal 2007, Vol.13 (31), p.8762-8783
Hauptverfasser:	Fürstner, Alois, Bonnekessel, Melanie, Blank, Jarred T., Radkowski, Karin, Seidel, Günter, Lacombe, Fabrice, Gabor, Barbara, Mynott, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	alkynes antibiotics Crystallography, X-Ray Lactones - chemical synthesis Lactones - chemistry macrocyclization metathesis Models, Molecular Molecular Conformation natural products Stereoisomerism
Online-Zugang:	Volltext
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