Ovariectomy Delays Alveolar Wound Healing After Molar Extractions in Rats
Purpose This study was conducted to investigate the morphological effects of the absence of estrogen on alveolar wound healing of young female rats after tooth extraction. Materials and Methods A total of 60 4- to 6-week-old female rats underwent bilateral ovariectomy (OVX) or sham operations. Three...
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| Veröffentlicht in: | Journal of oral and maxillofacial surgery 2007-11, Vol.65 (11), p.2248-2253 |
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| container_title | Journal of oral and maxillofacial surgery |
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| creator | Pereira, Michele Conceição, DDS, MSc Zecchin, Karina Gottardello, DDS, PhD Campagnoli, Eduardo Bauml, DDS, MSc Jorge, Jacks, DDS, PhD |
| description | Purpose This study was conducted to investigate the morphological effects of the absence of estrogen on alveolar wound healing of young female rats after tooth extraction. Materials and Methods A total of 60 4- to 6-week-old female rats underwent bilateral ovariectomy (OVX) or sham operations. Three weeks later, the first mandibular molars were extracted. Subsequently, the animals were killed by cervical dislocation 3, 5, 7, 14, 21, or 28 days after tooth extraction. The mandibles were removed, and serial transversal sections of mesial alveolus of the first mandibular molars were obtained for histometric analysis. Results OVX sockets showed significant increases in fibroblasts and collagen content 3 and 5 days after the extractions, followed by significant decreases in these parameters in the subsequent periods. In accordance with the decreased collagen content in the latest period of healing, new bone formation was significantly reduced in the OVX animals. Conclusion These findings suggest that the initial molecular changes observed in the absence of estrogen lead to delayed alveolar wound healing. |
| doi_str_mv | 10.1016/j.joms.2006.11.040 |
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Materials and Methods A total of 60 4- to 6-week-old female rats underwent bilateral ovariectomy (OVX) or sham operations. Three weeks later, the first mandibular molars were extracted. Subsequently, the animals were killed by cervical dislocation 3, 5, 7, 14, 21, or 28 days after tooth extraction. The mandibles were removed, and serial transversal sections of mesial alveolus of the first mandibular molars were obtained for histometric analysis. Results OVX sockets showed significant increases in fibroblasts and collagen content 3 and 5 days after the extractions, followed by significant decreases in these parameters in the subsequent periods. In accordance with the decreased collagen content in the latest period of healing, new bone formation was significantly reduced in the OVX animals. Conclusion These findings suggest that the initial molecular changes observed in the absence of estrogen lead to delayed alveolar wound healing.</description><identifier>ISSN: 0278-2391</identifier><identifier>EISSN: 1531-5053</identifier><identifier>DOI: 10.1016/j.joms.2006.11.040</identifier><identifier>PMID: 17954321</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Absorptiometry, Photon ; Alveolar Process - pathology ; Alveolar Process - physiopathology ; Animals ; Bone Density - physiology ; Collagen - analysis ; Dentistry ; Estrogens - physiology ; Female ; Fibroblasts - pathology ; Mandible - pathology ; Mandible - physiopathology ; Mandible - surgery ; Molar - surgery ; Osteogenesis - physiology ; Ovariectomy ; Ovary - physiology ; Rats ; Rats, Wistar ; Surgery ; Tibia - pathology ; Time Factors ; Tooth Extraction ; Tooth Socket - pathology ; Tooth Socket - physiopathology ; Wound Healing - physiology</subject><ispartof>Journal of oral and maxillofacial surgery, 2007-11, Vol.65 (11), p.2248-2253</ispartof><rights>American Association of Oral and Maxillofacial Surgeons</rights><rights>2007 American Association of Oral and Maxillofacial Surgeons</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-36b37d35a093eb4d026a3d4ea4ca8deb26c5a690cd113a31fca5d476d1bd1bae3</citedby><cites>FETCH-LOGICAL-c506t-36b37d35a093eb4d026a3d4ea4ca8deb26c5a690cd113a31fca5d476d1bd1bae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joms.2006.11.040$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17954321$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira, Michele Conceição, DDS, MSc</creatorcontrib><creatorcontrib>Zecchin, Karina Gottardello, DDS, PhD</creatorcontrib><creatorcontrib>Campagnoli, Eduardo Bauml, DDS, MSc</creatorcontrib><creatorcontrib>Jorge, Jacks, DDS, PhD</creatorcontrib><title>Ovariectomy Delays Alveolar Wound Healing After Molar Extractions in Rats</title><title>Journal of oral and maxillofacial surgery</title><addtitle>J Oral Maxillofac Surg</addtitle><description>Purpose This study was conducted to investigate the morphological effects of the absence of estrogen on alveolar wound healing of young female rats after tooth extraction. Materials and Methods A total of 60 4- to 6-week-old female rats underwent bilateral ovariectomy (OVX) or sham operations. Three weeks later, the first mandibular molars were extracted. Subsequently, the animals were killed by cervical dislocation 3, 5, 7, 14, 21, or 28 days after tooth extraction. The mandibles were removed, and serial transversal sections of mesial alveolus of the first mandibular molars were obtained for histometric analysis. Results OVX sockets showed significant increases in fibroblasts and collagen content 3 and 5 days after the extractions, followed by significant decreases in these parameters in the subsequent periods. In accordance with the decreased collagen content in the latest period of healing, new bone formation was significantly reduced in the OVX animals. Conclusion These findings suggest that the initial molecular changes observed in the absence of estrogen lead to delayed alveolar wound healing.</description><subject>Absorptiometry, Photon</subject><subject>Alveolar Process - pathology</subject><subject>Alveolar Process - physiopathology</subject><subject>Animals</subject><subject>Bone Density - physiology</subject><subject>Collagen - analysis</subject><subject>Dentistry</subject><subject>Estrogens - physiology</subject><subject>Female</subject><subject>Fibroblasts - pathology</subject><subject>Mandible - pathology</subject><subject>Mandible - physiopathology</subject><subject>Mandible - surgery</subject><subject>Molar - surgery</subject><subject>Osteogenesis - physiology</subject><subject>Ovariectomy</subject><subject>Ovary - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Surgery</subject><subject>Tibia - pathology</subject><subject>Time Factors</subject><subject>Tooth Extraction</subject><subject>Tooth Socket - pathology</subject><subject>Tooth Socket - physiopathology</subject><subject>Wound Healing - physiology</subject><issn>0278-2391</issn><issn>1531-5053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV2L1DAUhoMo7uzqH_BCeuVd6zlJk05BhGFddxdWFvzAy5AmZyS106xJOzj_3tQZELxQCJyLPO978byMvUCoEFC97qs-7FLFAVSFWEENj9gKpcBSghSP2Qp4sy65aPGMnafUAyDKRj1lZ9i0shYcV-z2fm-iJzuF3aF4R4M5pGIz7CkMJhZfwzy64obM4MdvxWY7USw-_P65-jlFYycfxlT4sfhopvSMPdmaIdHz071gX95ffb68Ke_ur28vN3ellaCmUqhONE5IA62grnbAlRGuJlNbs3bUcWWlUS1YhyiMwK010tWNctjlZ0hcsFfH3ocYfsyUJr3zydIwmJHCnLRa15y3Qv4X5FDL7AEzyI-gjSGlSFv9EP3OxING0Itp3evFtF5Ma0SdTefQy1P73O3I_Ymc1GbgzRGgLGPvKepkPY2WnI_Zt3bB_7v_7V9xm1fw1gzf6UCpD3Mcs2aNOnEN-tOy9TI1KOAcsBa_AE9lpEM</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Pereira, Michele Conceição, DDS, MSc</creator><creator>Zecchin, Karina Gottardello, DDS, PhD</creator><creator>Campagnoli, Eduardo Bauml, DDS, MSc</creator><creator>Jorge, Jacks, DDS, PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20071101</creationdate><title>Ovariectomy Delays Alveolar Wound Healing After Molar Extractions in Rats</title><author>Pereira, Michele Conceição, DDS, MSc ; Zecchin, Karina Gottardello, DDS, PhD ; Campagnoli, Eduardo Bauml, DDS, MSc ; Jorge, Jacks, DDS, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-36b37d35a093eb4d026a3d4ea4ca8deb26c5a690cd113a31fca5d476d1bd1bae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Absorptiometry, Photon</topic><topic>Alveolar Process - pathology</topic><topic>Alveolar Process - physiopathology</topic><topic>Animals</topic><topic>Bone Density - physiology</topic><topic>Collagen - analysis</topic><topic>Dentistry</topic><topic>Estrogens - physiology</topic><topic>Female</topic><topic>Fibroblasts - pathology</topic><topic>Mandible - pathology</topic><topic>Mandible - physiopathology</topic><topic>Mandible - surgery</topic><topic>Molar - surgery</topic><topic>Osteogenesis - physiology</topic><topic>Ovariectomy</topic><topic>Ovary - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Surgery</topic><topic>Tibia - pathology</topic><topic>Time Factors</topic><topic>Tooth Extraction</topic><topic>Tooth Socket - pathology</topic><topic>Tooth Socket - physiopathology</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pereira, Michele Conceição, DDS, MSc</creatorcontrib><creatorcontrib>Zecchin, Karina Gottardello, DDS, PhD</creatorcontrib><creatorcontrib>Campagnoli, Eduardo Bauml, DDS, MSc</creatorcontrib><creatorcontrib>Jorge, Jacks, DDS, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pereira, Michele Conceição, DDS, MSc</au><au>Zecchin, Karina Gottardello, DDS, PhD</au><au>Campagnoli, Eduardo Bauml, DDS, MSc</au><au>Jorge, Jacks, DDS, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovariectomy Delays Alveolar Wound Healing After Molar Extractions in Rats</atitle><jtitle>Journal of oral and maxillofacial surgery</jtitle><addtitle>J Oral Maxillofac Surg</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>65</volume><issue>11</issue><spage>2248</spage><epage>2253</epage><pages>2248-2253</pages><issn>0278-2391</issn><eissn>1531-5053</eissn><abstract>Purpose This study was conducted to investigate the morphological effects of the absence of estrogen on alveolar wound healing of young female rats after tooth extraction. Materials and Methods A total of 60 4- to 6-week-old female rats underwent bilateral ovariectomy (OVX) or sham operations. Three weeks later, the first mandibular molars were extracted. Subsequently, the animals were killed by cervical dislocation 3, 5, 7, 14, 21, or 28 days after tooth extraction. The mandibles were removed, and serial transversal sections of mesial alveolus of the first mandibular molars were obtained for histometric analysis. Results OVX sockets showed significant increases in fibroblasts and collagen content 3 and 5 days after the extractions, followed by significant decreases in these parameters in the subsequent periods. In accordance with the decreased collagen content in the latest period of healing, new bone formation was significantly reduced in the OVX animals. Conclusion These findings suggest that the initial molecular changes observed in the absence of estrogen lead to delayed alveolar wound healing.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17954321</pmid><doi>10.1016/j.joms.2006.11.040</doi><tpages>6</tpages></addata></record> |
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| subjects | Absorptiometry, Photon Alveolar Process - pathology Alveolar Process - physiopathology Animals Bone Density - physiology Collagen - analysis Dentistry Estrogens - physiology Female Fibroblasts - pathology Mandible - pathology Mandible - physiopathology Mandible - surgery Molar - surgery Osteogenesis - physiology Ovariectomy Ovary - physiology Rats Rats, Wistar Surgery Tibia - pathology Time Factors Tooth Extraction Tooth Socket - pathology Tooth Socket - physiopathology Wound Healing - physiology |
| title | Ovariectomy Delays Alveolar Wound Healing After Molar Extractions in Rats |
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