Hodgkin’s lymphoma in Indian children: Prevalence and significance of Epstein–Barr virus detection in Hodgkin’s and Reed–Sternberg cells
Abstract Aim This study was done to document the prevalence of Epstein–Barr virus (EBV) in Hodgkin’s lymphoma (HL) in children of North India. Methods 145 previously untreated children diagnosed with HL from 1991 to 2003 were included. Lymph node (LN) biopsies were studied and classified using World...
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| Veröffentlicht in: | European journal of cancer (1990) 2007-01, Vol.43 (1), p.161-168 |
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| container_title | European journal of cancer (1990) |
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| creator | Dinand, Veronique Dawar, Ramesh Arya, Laxman S Unni, Rajani Mohanty, Binimaya Singh, Rajvir |
| description | Abstract Aim This study was done to document the prevalence of Epstein–Barr virus (EBV) in Hodgkin’s lymphoma (HL) in children of North India. Methods 145 previously untreated children diagnosed with HL from 1991 to 2003 were included. Lymph node (LN) biopsies were studied and classified using World Health Organisation (WHO) classification. EBV detection was done by immunohistochemistry (IHC) and in situ hybridisation (ISH) in 145 cases and 25 age- and sex-matched controls. Patients were treated with chemotherapy alone. Results EBV was detected by IHC in 131 (90.3%) cases and by ISH in 126 (93.3%) out of 135 cases, and in none of the controls examined. With IHC and ISH combined, EBV positivity was seen in 96.6% and was significantly associated with younger age ( p = 0.012) and lower socioeconomic level ( p = 0.007). EBV status had no implication on treatment response and survival. Conclusion EBV detection in 96.6% of childhood HL in a population with almost universal EBV seroconversion, and in none of the control lymph nodes, suggests a causative role of EBV in most cases of Indian childhood HL. |
| doi_str_mv | 10.1016/j.ejca.2006.08.036 |
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Methods 145 previously untreated children diagnosed with HL from 1991 to 2003 were included. Lymph node (LN) biopsies were studied and classified using World Health Organisation (WHO) classification. EBV detection was done by immunohistochemistry (IHC) and in situ hybridisation (ISH) in 145 cases and 25 age- and sex-matched controls. Patients were treated with chemotherapy alone. Results EBV was detected by IHC in 131 (90.3%) cases and by ISH in 126 (93.3%) out of 135 cases, and in none of the controls examined. With IHC and ISH combined, EBV positivity was seen in 96.6% and was significantly associated with younger age ( p = 0.012) and lower socioeconomic level ( p = 0.007). EBV status had no implication on treatment response and survival. Conclusion EBV detection in 96.6% of childhood HL in a population with almost universal EBV seroconversion, and in none of the control lymph nodes, suggests a causative role of EBV in most cases of Indian childhood HL.</description><identifier>ISSN: 0959-8049</identifier><identifier>EISSN: 1879-0852</identifier><identifier>DOI: 10.1016/j.ejca.2006.08.036</identifier><identifier>PMID: 17113770</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Biological and medical sciences ; Case-Control Studies ; Child ; Child, Preschool ; Children ; Epstein-Barr Virus Infections - epidemiology ; Epstein-Barr Virus Infections - virology ; Epstein–Barr virus ; Female ; Hematology, Oncology and Palliative Medicine ; Herpesvirus 4, Human - isolation & purification ; Hodgkin Disease - epidemiology ; Hodgkin Disease - virology ; Hodgkin’s lymphoma ; Humans ; Hybridisation in situ ; Immunohistocytochemistry ; India - epidemiology ; Infant ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Prevalence ; Reed-Sternberg Cells - virology ; Retrospective Studies ; Socioeconomic status ; Treatment outcome ; Tumors</subject><ispartof>European journal of cancer (1990), 2007-01, Vol.43 (1), p.161-168</ispartof><rights>Elsevier Ltd</rights><rights>2006 Elsevier Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-9d0f81ce18b3f45e6bf6990e557b20a4598d16d79516c21ccb1f34b7d00c8dde3</citedby><cites>FETCH-LOGICAL-c420t-9d0f81ce18b3f45e6bf6990e557b20a4598d16d79516c21ccb1f34b7d00c8dde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejca.2006.08.036$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18467115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17113770$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dinand, Veronique</creatorcontrib><creatorcontrib>Dawar, Ramesh</creatorcontrib><creatorcontrib>Arya, Laxman S</creatorcontrib><creatorcontrib>Unni, Rajani</creatorcontrib><creatorcontrib>Mohanty, Binimaya</creatorcontrib><creatorcontrib>Singh, Rajvir</creatorcontrib><title>Hodgkin’s lymphoma in Indian children: Prevalence and significance of Epstein–Barr virus detection in Hodgkin’s and Reed–Sternberg cells</title><title>European journal of cancer (1990)</title><addtitle>Eur J Cancer</addtitle><description>Abstract Aim This study was done to document the prevalence of Epstein–Barr virus (EBV) in Hodgkin’s lymphoma (HL) in children of North India. Methods 145 previously untreated children diagnosed with HL from 1991 to 2003 were included. Lymph node (LN) biopsies were studied and classified using World Health Organisation (WHO) classification. EBV detection was done by immunohistochemistry (IHC) and in situ hybridisation (ISH) in 145 cases and 25 age- and sex-matched controls. Patients were treated with chemotherapy alone. Results EBV was detected by IHC in 131 (90.3%) cases and by ISH in 126 (93.3%) out of 135 cases, and in none of the controls examined. With IHC and ISH combined, EBV positivity was seen in 96.6% and was significantly associated with younger age ( p = 0.012) and lower socioeconomic level ( p = 0.007). EBV status had no implication on treatment response and survival. Conclusion EBV detection in 96.6% of childhood HL in a population with almost universal EBV seroconversion, and in none of the control lymph nodes, suggests a causative role of EBV in most cases of Indian childhood HL.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Epstein-Barr Virus Infections - epidemiology</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Epstein–Barr virus</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Hodgkin Disease - epidemiology</subject><subject>Hodgkin Disease - virology</subject><subject>Hodgkin’s lymphoma</subject><subject>Humans</subject><subject>Hybridisation in situ</subject><subject>Immunohistocytochemistry</subject><subject>India - epidemiology</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Prevalence</subject><subject>Reed-Sternberg Cells - virology</subject><subject>Retrospective Studies</subject><subject>Socioeconomic status</subject><subject>Treatment outcome</subject><subject>Tumors</subject><issn>0959-8049</issn><issn>1879-0852</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks2KFDEUhQtRnHb0BVxINrqr8qZ-UomIoMPoDAwojq5DKrnVk5rqVJtUNfTORxBc-Xo-iQndMOLCVeDynZPLOTfLnlIoKFD2cihw0KooAVgBvICK3ctWlLciB96U97MViEbkHGpxkj0KYQCAltfwMDuhLaVV28Iq-3ExmfWtdb-__wpk3G-2N9NGEevIpTNWOaJv7Gg8ulfkk8edGtFpJMoZEuza2d5qlQZTT863Ycbk8_Od8p7srF8CMTijnu3kkuPfPyWHz4gm4tczetehXxON4xgeZw96NQZ8cnxPs6_vz7-cXeRXHz9cnr29ynVdwpwLAz2nGinvqr5ukHU9EwKwadquBFU3ghvKTCsaynRJte5oX9VdawA0Nwar0-zFwXfrp28LhllubEgbKIfTEiTjdVky0UawPIDaTyF47OXW243ye0lBph7kIFMPMvUggcvYQxQ9O7ov3QbNneQYfASeHwEVtBp7H3O04Y7jNYtoE7nXBw5jFjuLXgZtUwnG-hitNJP9_x5v_pHr0brY2niLewzDtHgXU5ZUhlKCvE4Xkw4GGADnZVX9AYBHwPw</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Dinand, Veronique</creator><creator>Dawar, Ramesh</creator><creator>Arya, Laxman S</creator><creator>Unni, Rajani</creator><creator>Mohanty, Binimaya</creator><creator>Singh, Rajvir</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Hodgkin’s lymphoma in Indian children: Prevalence and significance of Epstein–Barr virus detection in Hodgkin’s and Reed–Sternberg cells</title><author>Dinand, Veronique ; Dawar, Ramesh ; Arya, Laxman S ; Unni, Rajani ; Mohanty, Binimaya ; Singh, Rajvir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-9d0f81ce18b3f45e6bf6990e557b20a4598d16d79516c21ccb1f34b7d00c8dde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Epstein-Barr Virus Infections - epidemiology</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Epstein–Barr virus</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Hodgkin Disease - epidemiology</topic><topic>Hodgkin Disease - virology</topic><topic>Hodgkin’s lymphoma</topic><topic>Humans</topic><topic>Hybridisation in situ</topic><topic>Immunohistocytochemistry</topic><topic>India - epidemiology</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Prevalence</topic><topic>Reed-Sternberg Cells - virology</topic><topic>Retrospective Studies</topic><topic>Socioeconomic status</topic><topic>Treatment outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dinand, Veronique</creatorcontrib><creatorcontrib>Dawar, Ramesh</creatorcontrib><creatorcontrib>Arya, Laxman S</creatorcontrib><creatorcontrib>Unni, Rajani</creatorcontrib><creatorcontrib>Mohanty, Binimaya</creatorcontrib><creatorcontrib>Singh, Rajvir</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cancer (1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dinand, Veronique</au><au>Dawar, Ramesh</au><au>Arya, Laxman S</au><au>Unni, Rajani</au><au>Mohanty, Binimaya</au><au>Singh, Rajvir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hodgkin’s lymphoma in Indian children: Prevalence and significance of Epstein–Barr virus detection in Hodgkin’s and Reed–Sternberg cells</atitle><jtitle>European journal of cancer (1990)</jtitle><addtitle>Eur J Cancer</addtitle><date>2007-01</date><risdate>2007</risdate><volume>43</volume><issue>1</issue><spage>161</spage><epage>168</epage><pages>161-168</pages><issn>0959-8049</issn><eissn>1879-0852</eissn><abstract>Abstract Aim This study was done to document the prevalence of Epstein–Barr virus (EBV) in Hodgkin’s lymphoma (HL) in children of North India. Methods 145 previously untreated children diagnosed with HL from 1991 to 2003 were included. Lymph node (LN) biopsies were studied and classified using World Health Organisation (WHO) classification. EBV detection was done by immunohistochemistry (IHC) and in situ hybridisation (ISH) in 145 cases and 25 age- and sex-matched controls. Patients were treated with chemotherapy alone. Results EBV was detected by IHC in 131 (90.3%) cases and by ISH in 126 (93.3%) out of 135 cases, and in none of the controls examined. With IHC and ISH combined, EBV positivity was seen in 96.6% and was significantly associated with younger age ( p = 0.012) and lower socioeconomic level ( p = 0.007). EBV status had no implication on treatment response and survival. Conclusion EBV detection in 96.6% of childhood HL in a population with almost universal EBV seroconversion, and in none of the control lymph nodes, suggests a causative role of EBV in most cases of Indian childhood HL.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>17113770</pmid><doi>10.1016/j.ejca.2006.08.036</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Biological and medical sciences Case-Control Studies Child Child, Preschool Children Epstein-Barr Virus Infections - epidemiology Epstein-Barr Virus Infections - virology Epstein–Barr virus Female Hematology, Oncology and Palliative Medicine Herpesvirus 4, Human - isolation & purification Hodgkin Disease - epidemiology Hodgkin Disease - virology Hodgkin’s lymphoma Humans Hybridisation in situ Immunohistocytochemistry India - epidemiology Infant Male Medical sciences Pharmacology. Drug treatments Prevalence Reed-Sternberg Cells - virology Retrospective Studies Socioeconomic status Treatment outcome Tumors |
| title | Hodgkin’s lymphoma in Indian children: Prevalence and significance of Epstein–Barr virus detection in Hodgkin’s and Reed–Sternberg cells |
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