PICH, a Centromere-Associated SNF2 Family ATPase, Is Regulated by Plk1 and Required for the Spindle Checkpoint

We identify PICH (Plk1-interacting checkpoint “helicase”), a member of the SNF2 ATPase family, as an interaction partner and substrate of Plk1. Following phosphorylation of PICH on the Cdk1 site T1063, Plk1 is recruited to PICH and controls its localization. Starting in prometaphase, PICH accumulate...

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Veröffentlicht in:	Cell 2007-01, Vol.128 (1), p.101-114
Hauptverfasser:	Baumann, Christoph, Körner, Roman, Hofmann, Kay, Nigg, Erich A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Calcium-Binding Proteins - metabolism Cell Cycle Proteins - metabolism Centromere - metabolism DNA Helicases - chemistry DNA Helicases - deficiency DNA Helicases - metabolism DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - deficiency DNA-Binding Proteins - metabolism HeLa Cells Humans Kinetochores - metabolism Mad2 Proteins Mitosis Models, Biological Molecular Sequence Data Polo-Like Kinase 1 Protein Binding Protein Serine-Threonine Kinases - metabolism Protein Structure, Tertiary Protein Transport Proto-Oncogene Proteins - metabolism Repressor Proteins - metabolism Signal Transduction Spindle Apparatus - metabolism Substrate Specificity
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