Systemic Cytokines, Clinical and Physiological Changes in Patients Hospitalized for Exacerbation of COPD
Background:Systemic inflammation in patients with COPD may worsen during exacerbations, but there is limited information relating levels of systemic inflammatory markers with symptoms and physiologic changes during an exacerbation Methods:We measured dyspnea using the visual analog scale, pulmonary...
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| Veröffentlicht in: | Chest 2007-01, Vol.131 (1), p.37-43 |
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| creator | Pinto-Plata, Victor M. Livnat, Guy Girish, Mirle Cabral, Howard Masdin, Phil Linacre, Paul Dew, Rick Kenney, Lawrence Celli, Bartolome R. |
| description | Background:Systemic inflammation in patients with COPD may worsen during exacerbations, but there is limited information relating levels of systemic inflammatory markers with symptoms and physiologic changes during an exacerbation
Methods:We measured dyspnea using the visual analog scale, pulmonary function tests, hemograms, and plasma levels for interleukin (IL)-6, IL-8, leukotriene B4(LTB4), tumor necrosis factor-A, and secretory leukocyte protease inhibitor (SLPI) in 20 patients on admission to a hospital for exacerbation of COPD (ECOPD), 48 h later (interim), and 8 weeks after hospital discharge (recovery).
Results:Dyspnea was present in all patients. Inspiratory capacity improved faster than FEV1. Compared to recovery, there was a significant increase in the mean (± SD) hospital admission plasma levels of IL-6 (6.38 ± 0.72 to 2.80 ± 0.79 pg/mL; p = 0.0001), IL-8 (8.18 ± 0.85 to 3.72 ± 0.85 pg/mL; p = 0.002), and LTB4 (8,675 ± 1,652 to 2,534 ± 1,813 pg/mL; p = 0.003), and the percentages of segmented neutrophils (79 to 69%; p < 0.02) and band forms (7.3 to 1.0%; p < 0.01) in peripheral blood, with no changes in TNF-A and SLPI. There were significant correlations between changes in IL-6 (r= 0.61; p = 0.01) and IL-8 (r= 0.56; p = 0.04) with changes in dyspnea and levels of IL-6 (r= −0.51; p = 0.04) and TNF-A (r= −0.71; p < 0.02) with changes in FEV1.
Conclusions:Hospitalized patients with ECOPDs experience significant changes in systemic cytokine levels that correlate with symptoms and lung function. An ECOPD represents not only a worsening of airflow obstruction but also increased systemic demand in a host with limited ventilatory reserve. |
| doi_str_mv | 10.1378/chest.06-0668 |
| format | Article |
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Methods:We measured dyspnea using the visual analog scale, pulmonary function tests, hemograms, and plasma levels for interleukin (IL)-6, IL-8, leukotriene B4(LTB4), tumor necrosis factor-A, and secretory leukocyte protease inhibitor (SLPI) in 20 patients on admission to a hospital for exacerbation of COPD (ECOPD), 48 h later (interim), and 8 weeks after hospital discharge (recovery).
Results:Dyspnea was present in all patients. Inspiratory capacity improved faster than FEV1. Compared to recovery, there was a significant increase in the mean (± SD) hospital admission plasma levels of IL-6 (6.38 ± 0.72 to 2.80 ± 0.79 pg/mL; p = 0.0001), IL-8 (8.18 ± 0.85 to 3.72 ± 0.85 pg/mL; p = 0.002), and LTB4 (8,675 ± 1,652 to 2,534 ± 1,813 pg/mL; p = 0.003), and the percentages of segmented neutrophils (79 to 69%; p < 0.02) and band forms (7.3 to 1.0%; p < 0.01) in peripheral blood, with no changes in TNF-A and SLPI. There were significant correlations between changes in IL-6 (r= 0.61; p = 0.01) and IL-8 (r= 0.56; p = 0.04) with changes in dyspnea and levels of IL-6 (r= −0.51; p = 0.04) and TNF-A (r= −0.71; p < 0.02) with changes in FEV1.
Conclusions:Hospitalized patients with ECOPDs experience significant changes in systemic cytokine levels that correlate with symptoms and lung function. An ECOPD represents not only a worsening of airflow obstruction but also increased systemic demand in a host with limited ventilatory reserve.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.06-0668</identifier><identifier>PMID: 17218554</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomarkers - blood ; Cardiology. Vascular system ; chronic obstructive lung disease ; Chronic obstructive pulmonary disease, asthma ; cytokines ; Cytokines - blood ; dyspnea ; exacerbation ; Female ; Hospitalization ; Humans ; Interleukin-6 - blood ; Interleukin-8 - blood ; Leukotriene B4 - blood ; Linear Models ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Respiratory Function Tests ; Respiratory system : syndromes and miscellaneous diseases ; Secretory Leukocyte Peptidase Inhibitor - blood ; Severity of Illness Index ; Statistics, Nonparametric ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Chest, 2007-01, Vol.131 (1), p.37-43</ispartof><rights>2007 The American College of Chest Physicians</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-34a94f733143004c9a32160ea9120b16958ceffbd16d81d952f0e7c3e7fa5df33</citedby><cites>FETCH-LOGICAL-c474t-34a94f733143004c9a32160ea9120b16958ceffbd16d81d952f0e7c3e7fa5df33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18440187$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17218554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pinto-Plata, Victor M.</creatorcontrib><creatorcontrib>Livnat, Guy</creatorcontrib><creatorcontrib>Girish, Mirle</creatorcontrib><creatorcontrib>Cabral, Howard</creatorcontrib><creatorcontrib>Masdin, Phil</creatorcontrib><creatorcontrib>Linacre, Paul</creatorcontrib><creatorcontrib>Dew, Rick</creatorcontrib><creatorcontrib>Kenney, Lawrence</creatorcontrib><creatorcontrib>Celli, Bartolome R.</creatorcontrib><title>Systemic Cytokines, Clinical and Physiological Changes in Patients Hospitalized for Exacerbation of COPD</title><title>Chest</title><addtitle>Chest</addtitle><description>Background:Systemic inflammation in patients with COPD may worsen during exacerbations, but there is limited information relating levels of systemic inflammatory markers with symptoms and physiologic changes during an exacerbation
Methods:We measured dyspnea using the visual analog scale, pulmonary function tests, hemograms, and plasma levels for interleukin (IL)-6, IL-8, leukotriene B4(LTB4), tumor necrosis factor-A, and secretory leukocyte protease inhibitor (SLPI) in 20 patients on admission to a hospital for exacerbation of COPD (ECOPD), 48 h later (interim), and 8 weeks after hospital discharge (recovery).
Results:Dyspnea was present in all patients. Inspiratory capacity improved faster than FEV1. Compared to recovery, there was a significant increase in the mean (± SD) hospital admission plasma levels of IL-6 (6.38 ± 0.72 to 2.80 ± 0.79 pg/mL; p = 0.0001), IL-8 (8.18 ± 0.85 to 3.72 ± 0.85 pg/mL; p = 0.002), and LTB4 (8,675 ± 1,652 to 2,534 ± 1,813 pg/mL; p = 0.003), and the percentages of segmented neutrophils (79 to 69%; p < 0.02) and band forms (7.3 to 1.0%; p < 0.01) in peripheral blood, with no changes in TNF-A and SLPI. There were significant correlations between changes in IL-6 (r= 0.61; p = 0.01) and IL-8 (r= 0.56; p = 0.04) with changes in dyspnea and levels of IL-6 (r= −0.51; p = 0.04) and TNF-A (r= −0.71; p < 0.02) with changes in FEV1.
Conclusions:Hospitalized patients with ECOPDs experience significant changes in systemic cytokine levels that correlate with symptoms and lung function. An ECOPD represents not only a worsening of airflow obstruction but also increased systemic demand in a host with limited ventilatory reserve.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology. Vascular system</subject><subject>chronic obstructive lung disease</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>cytokines</subject><subject>Cytokines - blood</subject><subject>dyspnea</subject><subject>exacerbation</subject><subject>Female</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-8 - blood</subject><subject>Leukotriene B4 - blood</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - blood</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Secretory Leukocyte Peptidase Inhibitor - blood</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1vEzEURS0EoqGwZIu8gRUT_MaeryUaCkWq1EjA2nI8zxkXjx3sSSH8epxOpK5YWc_v3GvrEPIa2Bp4037QI6Z5zeqC1XX7hKyg41DwSvCnZMUYlAWvu_KCvEjpjuUZuvo5uYCmhLaqxIqM345pxslq2h_n8NN6TO9p76y3Wjmq_EA34zHZ4MLu4aYfld9hotbTjZot-jnR65D2dlbO_sWBmhDp1R-lMW7zPngaDO1vN59ekmdGuYSvzucl-fH56nt_Xdzcfvnaf7wptGjEXHChOmEazkFwxoTuFC-hZqg6KNkW6q5qNRqzHaAeWhi6qjQMG82xMaoaDOeX5N3Su4_h1yG7kZNNGp1THsMhyboVJVQVZLBYQB1DShGN3Ec7qXiUwORJrXxQK1ktT2oz_-ZcfNhOODzSZ5cZeHsGVMqqTFRe2_TItUIwaJvMrRdutLvxt40o06Scy7V8efIuHKJXDjhIkPwUaJYAZm_3FqNMOpvXOOSwnuUQ7H_-_A82FqZh</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Pinto-Plata, Victor M.</creator><creator>Livnat, Guy</creator><creator>Girish, Mirle</creator><creator>Cabral, Howard</creator><creator>Masdin, Phil</creator><creator>Linacre, Paul</creator><creator>Dew, Rick</creator><creator>Kenney, Lawrence</creator><creator>Celli, Bartolome R.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Systemic Cytokines, Clinical and Physiological Changes in Patients Hospitalized for Exacerbation of COPD</title><author>Pinto-Plata, Victor M. ; Livnat, Guy ; Girish, Mirle ; Cabral, Howard ; Masdin, Phil ; Linacre, Paul ; Dew, Rick ; Kenney, Lawrence ; Celli, Bartolome R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-34a94f733143004c9a32160ea9120b16958ceffbd16d81d952f0e7c3e7fa5df33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology. Vascular system</topic><topic>chronic obstructive lung disease</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>cytokines</topic><topic>Cytokines - blood</topic><topic>dyspnea</topic><topic>exacerbation</topic><topic>Female</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-8 - blood</topic><topic>Leukotriene B4 - blood</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - blood</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Secretory Leukocyte Peptidase Inhibitor - blood</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pinto-Plata, Victor M.</creatorcontrib><creatorcontrib>Livnat, Guy</creatorcontrib><creatorcontrib>Girish, Mirle</creatorcontrib><creatorcontrib>Cabral, Howard</creatorcontrib><creatorcontrib>Masdin, Phil</creatorcontrib><creatorcontrib>Linacre, Paul</creatorcontrib><creatorcontrib>Dew, Rick</creatorcontrib><creatorcontrib>Kenney, Lawrence</creatorcontrib><creatorcontrib>Celli, Bartolome R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pinto-Plata, Victor M.</au><au>Livnat, Guy</au><au>Girish, Mirle</au><au>Cabral, Howard</au><au>Masdin, Phil</au><au>Linacre, Paul</au><au>Dew, Rick</au><au>Kenney, Lawrence</au><au>Celli, Bartolome R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic Cytokines, Clinical and Physiological Changes in Patients Hospitalized for Exacerbation of COPD</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>2007-01</date><risdate>2007</risdate><volume>131</volume><issue>1</issue><spage>37</spage><epage>43</epage><pages>37-43</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>Background:Systemic inflammation in patients with COPD may worsen during exacerbations, but there is limited information relating levels of systemic inflammatory markers with symptoms and physiologic changes during an exacerbation
Methods:We measured dyspnea using the visual analog scale, pulmonary function tests, hemograms, and plasma levels for interleukin (IL)-6, IL-8, leukotriene B4(LTB4), tumor necrosis factor-A, and secretory leukocyte protease inhibitor (SLPI) in 20 patients on admission to a hospital for exacerbation of COPD (ECOPD), 48 h later (interim), and 8 weeks after hospital discharge (recovery).
Results:Dyspnea was present in all patients. Inspiratory capacity improved faster than FEV1. Compared to recovery, there was a significant increase in the mean (± SD) hospital admission plasma levels of IL-6 (6.38 ± 0.72 to 2.80 ± 0.79 pg/mL; p = 0.0001), IL-8 (8.18 ± 0.85 to 3.72 ± 0.85 pg/mL; p = 0.002), and LTB4 (8,675 ± 1,652 to 2,534 ± 1,813 pg/mL; p = 0.003), and the percentages of segmented neutrophils (79 to 69%; p < 0.02) and band forms (7.3 to 1.0%; p < 0.01) in peripheral blood, with no changes in TNF-A and SLPI. There were significant correlations between changes in IL-6 (r= 0.61; p = 0.01) and IL-8 (r= 0.56; p = 0.04) with changes in dyspnea and levels of IL-6 (r= −0.51; p = 0.04) and TNF-A (r= −0.71; p < 0.02) with changes in FEV1.
Conclusions:Hospitalized patients with ECOPDs experience significant changes in systemic cytokine levels that correlate with symptoms and lung function. An ECOPD represents not only a worsening of airflow obstruction but also increased systemic demand in a host with limited ventilatory reserve.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>17218554</pmid><doi>10.1378/chest.06-0668</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biological and medical sciences Biomarkers - blood Cardiology. Vascular system chronic obstructive lung disease Chronic obstructive pulmonary disease, asthma cytokines Cytokines - blood dyspnea exacerbation Female Hospitalization Humans Interleukin-6 - blood Interleukin-8 - blood Leukotriene B4 - blood Linear Models Male Medical sciences Middle Aged Pneumology Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - physiopathology Respiratory Function Tests Respiratory system : syndromes and miscellaneous diseases Secretory Leukocyte Peptidase Inhibitor - blood Severity of Illness Index Statistics, Nonparametric Tumor Necrosis Factor-alpha - blood |
| title | Systemic Cytokines, Clinical and Physiological Changes in Patients Hospitalized for Exacerbation of COPD |
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