6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis
Summary Fluorescence in situ hybridisation (FISH) is an effective technique for the cytogenetic analysis of Waldenström macroglobulinemia (WM), but the potential impact of molecular cytogenetics on disease evolution and as a prognostic marker is still unknown. Deletion of the long arm of chromosome...
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| Veröffentlicht in: | British journal of haematology 2007-01, Vol.136 (1), p.80-86 |
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| creator | Ocio, E. M. Schop, R. F. J. Gonzalez, B. Van Wier, S. A. Hernandez‐Rivas, J. M. Gutierrez, N. C. Garcia‐Sanz, R. Moro, M. J. Aguilera, C. Hernandez, J. Xu, R. Greipp, P. R. Dispenzieri, A. Jalal, S. M. Lacy, M. Q. Gonzalez‐Paz, N. Gertz, M. A. San Miguel, J. F. Fonseca, R. |
| description | Summary
Fluorescence in situ hybridisation (FISH) is an effective technique for the cytogenetic analysis of Waldenström macroglobulinemia (WM), but the potential impact of molecular cytogenetics on disease evolution and as a prognostic marker is still unknown. Deletion of the long arm of chromosome 6 (6q−) is the most frequent cytogenetic abnormality in WM. This study analysed the prevalence of this aberration in 102 WM patients, and correlated it with disease characteristics. The incidence of 6q21 deletion was 7% by conventional cytogenetics and 34% when analysed by FISH (54% when cytoplasmic immunoglobulin M‐FISH was used). Patients with deletion of 6q displayed features of adverse prognosis, such as higher levels of β2‐microglobulin and monoclonal paraprotein and a greater tendency to display anaemia and hypoalbuminemia. Interestingly, there was a correlation between the presence of 6q deletion and the International Staging System prognostic index (incidence of 6q− among patients stratified in stages 1, 2 and 3 was 24%, 42% and 67% respectively). Those patients diagnosed with smouldering WM who displayed the abnormality showed a trend to an earlier requirement of treatment. Finally, the survival analysis did not show differences between the two groups of patients, probably due to the short follow up of our series. |
| doi_str_mv | 10.1111/j.1365-2141.2006.06389.x |
| format | Article |
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Fluorescence in situ hybridisation (FISH) is an effective technique for the cytogenetic analysis of Waldenström macroglobulinemia (WM), but the potential impact of molecular cytogenetics on disease evolution and as a prognostic marker is still unknown. Deletion of the long arm of chromosome 6 (6q−) is the most frequent cytogenetic abnormality in WM. This study analysed the prevalence of this aberration in 102 WM patients, and correlated it with disease characteristics. The incidence of 6q21 deletion was 7% by conventional cytogenetics and 34% when analysed by FISH (54% when cytoplasmic immunoglobulin M‐FISH was used). Patients with deletion of 6q displayed features of adverse prognosis, such as higher levels of β2‐microglobulin and monoclonal paraprotein and a greater tendency to display anaemia and hypoalbuminemia. Interestingly, there was a correlation between the presence of 6q deletion and the International Staging System prognostic index (incidence of 6q− among patients stratified in stages 1, 2 and 3 was 24%, 42% and 67% respectively). Those patients diagnosed with smouldering WM who displayed the abnormality showed a trend to an earlier requirement of treatment. Finally, the survival analysis did not show differences between the two groups of patients, probably due to the short follow up of our series.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2006.06389.x</identifier><identifier>PMID: 17222197</identifier><identifier>CODEN: BJHEAL</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>6q deletion ; Adult ; Aged ; Aged, 80 and over ; Albuminuria ; Anemia ; beta 2-Microglobulin - analysis ; Biological and medical sciences ; Blood Sedimentation ; C-Reactive Protein - analysis ; Chi-Square Distribution ; Chromosome Deletion ; Cytogenetics ; Disease Progression ; DNA deletions ; Female ; fluorescence in situ hybridisation ; Hematologic and hematopoietic diseases ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulin M - blood ; Immunoglobulinopathies ; Immunopathology ; In Situ Hybridization, Fluorescence ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Prognosis ; prognostic ; Statistics, Nonparametric ; Waldenstrom Macroglobulinemia - blood ; Waldenstrom Macroglobulinemia - genetics ; Waldenstrom Macroglobulinemia - urine ; Waldenström macroglobulinemia</subject><ispartof>British journal of haematology, 2007-01, Vol.136 (1), p.80-86</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4479-8e6d64921ffe5d60ee8fd11d9325729215ce27800aa36db635c6399b3ab962423</citedby><cites>FETCH-LOGICAL-c4479-8e6d64921ffe5d60ee8fd11d9325729215ce27800aa36db635c6399b3ab962423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2006.06389.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2006.06389.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,4010,27900,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18487775$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17222197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ocio, E. M.</creatorcontrib><creatorcontrib>Schop, R. F. J.</creatorcontrib><creatorcontrib>Gonzalez, B.</creatorcontrib><creatorcontrib>Van Wier, S. A.</creatorcontrib><creatorcontrib>Hernandez‐Rivas, J. M.</creatorcontrib><creatorcontrib>Gutierrez, N. C.</creatorcontrib><creatorcontrib>Garcia‐Sanz, R.</creatorcontrib><creatorcontrib>Moro, M. J.</creatorcontrib><creatorcontrib>Aguilera, C.</creatorcontrib><creatorcontrib>Hernandez, J.</creatorcontrib><creatorcontrib>Xu, R.</creatorcontrib><creatorcontrib>Greipp, P. R.</creatorcontrib><creatorcontrib>Dispenzieri, A.</creatorcontrib><creatorcontrib>Jalal, S. M.</creatorcontrib><creatorcontrib>Lacy, M. Q.</creatorcontrib><creatorcontrib>Gonzalez‐Paz, N.</creatorcontrib><creatorcontrib>Gertz, M. A.</creatorcontrib><creatorcontrib>San Miguel, J. F.</creatorcontrib><creatorcontrib>Fonseca, R.</creatorcontrib><title>6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
Fluorescence in situ hybridisation (FISH) is an effective technique for the cytogenetic analysis of Waldenström macroglobulinemia (WM), but the potential impact of molecular cytogenetics on disease evolution and as a prognostic marker is still unknown. Deletion of the long arm of chromosome 6 (6q−) is the most frequent cytogenetic abnormality in WM. This study analysed the prevalence of this aberration in 102 WM patients, and correlated it with disease characteristics. The incidence of 6q21 deletion was 7% by conventional cytogenetics and 34% when analysed by FISH (54% when cytoplasmic immunoglobulin M‐FISH was used). Patients with deletion of 6q displayed features of adverse prognosis, such as higher levels of β2‐microglobulin and monoclonal paraprotein and a greater tendency to display anaemia and hypoalbuminemia. Interestingly, there was a correlation between the presence of 6q deletion and the International Staging System prognostic index (incidence of 6q− among patients stratified in stages 1, 2 and 3 was 24%, 42% and 67% respectively). Those patients diagnosed with smouldering WM who displayed the abnormality showed a trend to an earlier requirement of treatment. Finally, the survival analysis did not show differences between the two groups of patients, probably due to the short follow up of our series.</description><subject>6q deletion</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Albuminuria</subject><subject>Anemia</subject><subject>beta 2-Microglobulin - analysis</subject><subject>Biological and medical sciences</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - analysis</subject><subject>Chi-Square Distribution</subject><subject>Chromosome Deletion</subject><subject>Cytogenetics</subject><subject>Disease Progression</subject><subject>DNA deletions</subject><subject>Female</subject><subject>fluorescence in situ hybridisation</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulin M - blood</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prognosis</subject><subject>prognostic</subject><subject>Statistics, Nonparametric</subject><subject>Waldenstrom Macroglobulinemia - blood</subject><subject>Waldenstrom Macroglobulinemia - genetics</subject><subject>Waldenstrom Macroglobulinemia - urine</subject><subject>Waldenström macroglobulinemia</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtu1TAQhi0EoofCK1TelF2Cb7GdRRelAgqqxIaqOywnnrQ-cpI2k_TyYrwAL4bDOaJbvLFlf79n5iOEclbyvD5sSy51VQiueCkY0yXT0tbl4wuy-ffwkmwYY6bgTNkD8gZxyxiXrOKvyQE3Qghemw35qe9ogARzHAcaB3rlU4AB5-n3r572vp3G6zQ2S4oD9NHTiNQjjm30MwT6EOcb2oGflwmQjh314R4mBHqbY8OIEd-SV51PCO_2-yG5_Pzpx9l5cfH9y9ez04uiVcrUhQUdtKoF7zqogmYAtguch1qKyoh8X7UgjGXMe6lDo2XValnXjfRNrYUS8pC83_2bK98tgLPrI7aQkh9gXNBpqwSzXGXQ7sA8GeIEnbudYu-nJ8eZW926rVsVulWhW926v27dY44e7WssTQ_hObiXmYHjPeCx9amb_NBGfOasssaYKnMnO-4hJnj67wbcx2_n60n-AU7Olf8</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Ocio, E. M.</creator><creator>Schop, R. F. J.</creator><creator>Gonzalez, B.</creator><creator>Van Wier, S. A.</creator><creator>Hernandez‐Rivas, J. M.</creator><creator>Gutierrez, N. C.</creator><creator>Garcia‐Sanz, R.</creator><creator>Moro, M. J.</creator><creator>Aguilera, C.</creator><creator>Hernandez, J.</creator><creator>Xu, R.</creator><creator>Greipp, P. R.</creator><creator>Dispenzieri, A.</creator><creator>Jalal, S. M.</creator><creator>Lacy, M. Q.</creator><creator>Gonzalez‐Paz, N.</creator><creator>Gertz, M. A.</creator><creator>San Miguel, J. F.</creator><creator>Fonseca, R.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis</title><author>Ocio, E. M. ; Schop, R. F. J. ; Gonzalez, B. ; Van Wier, S. A. ; Hernandez‐Rivas, J. M. ; Gutierrez, N. C. ; Garcia‐Sanz, R. ; Moro, M. J. ; Aguilera, C. ; Hernandez, J. ; Xu, R. ; Greipp, P. R. ; Dispenzieri, A. ; Jalal, S. M. ; Lacy, M. Q. ; Gonzalez‐Paz, N. ; Gertz, M. A. ; San Miguel, J. F. ; Fonseca, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4479-8e6d64921ffe5d60ee8fd11d9325729215ce27800aa36db635c6399b3ab962423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>6q deletion</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Albuminuria</topic><topic>Anemia</topic><topic>beta 2-Microglobulin - analysis</topic><topic>Biological and medical sciences</topic><topic>Blood Sedimentation</topic><topic>C-Reactive Protein - analysis</topic><topic>Chi-Square Distribution</topic><topic>Chromosome Deletion</topic><topic>Cytogenetics</topic><topic>Disease Progression</topic><topic>DNA deletions</topic><topic>Female</topic><topic>fluorescence in situ hybridisation</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulin M - blood</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prognosis</topic><topic>prognostic</topic><topic>Statistics, Nonparametric</topic><topic>Waldenstrom Macroglobulinemia - blood</topic><topic>Waldenstrom Macroglobulinemia - genetics</topic><topic>Waldenstrom Macroglobulinemia - urine</topic><topic>Waldenström macroglobulinemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ocio, E. M.</creatorcontrib><creatorcontrib>Schop, R. F. J.</creatorcontrib><creatorcontrib>Gonzalez, B.</creatorcontrib><creatorcontrib>Van Wier, S. A.</creatorcontrib><creatorcontrib>Hernandez‐Rivas, J. M.</creatorcontrib><creatorcontrib>Gutierrez, N. 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F.</creatorcontrib><creatorcontrib>Fonseca, R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ocio, E. M.</au><au>Schop, R. F. J.</au><au>Gonzalez, B.</au><au>Van Wier, S. A.</au><au>Hernandez‐Rivas, J. M.</au><au>Gutierrez, N. C.</au><au>Garcia‐Sanz, R.</au><au>Moro, M. J.</au><au>Aguilera, C.</au><au>Hernandez, J.</au><au>Xu, R.</au><au>Greipp, P. R.</au><au>Dispenzieri, A.</au><au>Jalal, S. M.</au><au>Lacy, M. Q.</au><au>Gonzalez‐Paz, N.</au><au>Gertz, M. A.</au><au>San Miguel, J. F.</au><au>Fonseca, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2007-01</date><risdate>2007</risdate><volume>136</volume><issue>1</issue><spage>80</spage><epage>86</epage><pages>80-86</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><coden>BJHEAL</coden><abstract>Summary
Fluorescence in situ hybridisation (FISH) is an effective technique for the cytogenetic analysis of Waldenström macroglobulinemia (WM), but the potential impact of molecular cytogenetics on disease evolution and as a prognostic marker is still unknown. Deletion of the long arm of chromosome 6 (6q−) is the most frequent cytogenetic abnormality in WM. This study analysed the prevalence of this aberration in 102 WM patients, and correlated it with disease characteristics. The incidence of 6q21 deletion was 7% by conventional cytogenetics and 34% when analysed by FISH (54% when cytoplasmic immunoglobulin M‐FISH was used). Patients with deletion of 6q displayed features of adverse prognosis, such as higher levels of β2‐microglobulin and monoclonal paraprotein and a greater tendency to display anaemia and hypoalbuminemia. Interestingly, there was a correlation between the presence of 6q deletion and the International Staging System prognostic index (incidence of 6q− among patients stratified in stages 1, 2 and 3 was 24%, 42% and 67% respectively). Those patients diagnosed with smouldering WM who displayed the abnormality showed a trend to an earlier requirement of treatment. Finally, the survival analysis did not show differences between the two groups of patients, probably due to the short follow up of our series.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17222197</pmid><doi>10.1111/j.1365-2141.2006.06389.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 6q deletion Adult Aged Aged, 80 and over Albuminuria Anemia beta 2-Microglobulin - analysis Biological and medical sciences Blood Sedimentation C-Reactive Protein - analysis Chi-Square Distribution Chromosome Deletion Cytogenetics Disease Progression DNA deletions Female fluorescence in situ hybridisation Hematologic and hematopoietic diseases Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulin M - blood Immunoglobulinopathies Immunopathology In Situ Hybridization, Fluorescence Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Prognosis prognostic Statistics, Nonparametric Waldenstrom Macroglobulinemia - blood Waldenstrom Macroglobulinemia - genetics Waldenstrom Macroglobulinemia - urine Waldenström macroglobulinemia |
| title | 6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis |
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