Applications of microfluidics for neuronal studies
Abstract Microfabrication processes have changed the technology used in consumer goods, and have now advanced into applications in biology. Microfluidic platforms are microfabricated tools that are gaining popularity for studies of molecular and cellular biology. These platforms can allow precise co...
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| Veröffentlicht in: | Journal of the neurological sciences 2007-01, Vol.252 (2), p.135-143 |
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| container_end_page | 143 |
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| container_issue | 2 |
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| container_title | Journal of the neurological sciences |
| container_volume | 252 |
| creator | Gross, Pamela G Kartalov, Emil P Scherer, Axel Weiner, Leslie P |
| description | Abstract Microfabrication processes have changed the technology used in consumer goods, and have now advanced into applications in biology. Microfluidic platforms are microfabricated tools that are gaining popularity for studies of molecular and cellular biology. These platforms can allow precise control of the environment surrounding individual cells and they have been used to study physiologic and pharmacologic responses at the single-cell level. This article reviews microfluidic technology with emphasis on advances that could apply to the study of the nervous system, including architecture for isolation of axons, integrated electrophysiology, patterned physical and chemical substrate cues, and devices for the precisely controlled delivery of possible therapeutic agents such as trophic factors and drugs. The potential of these chips for the study of neurological diseases is also discussed. |
| doi_str_mv | 10.1016/j.jns.2006.11.009 |
| format | Article |
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Microfluidic platforms are microfabricated tools that are gaining popularity for studies of molecular and cellular biology. These platforms can allow precise control of the environment surrounding individual cells and they have been used to study physiologic and pharmacologic responses at the single-cell level. This article reviews microfluidic technology with emphasis on advances that could apply to the study of the nervous system, including architecture for isolation of axons, integrated electrophysiology, patterned physical and chemical substrate cues, and devices for the precisely controlled delivery of possible therapeutic agents such as trophic factors and drugs. 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Microfluidic platforms are microfabricated tools that are gaining popularity for studies of molecular and cellular biology. These platforms can allow precise control of the environment surrounding individual cells and they have been used to study physiologic and pharmacologic responses at the single-cell level. This article reviews microfluidic technology with emphasis on advances that could apply to the study of the nervous system, including architecture for isolation of axons, integrated electrophysiology, patterned physical and chemical substrate cues, and devices for the precisely controlled delivery of possible therapeutic agents such as trophic factors and drugs. The potential of these chips for the study of neurological diseases is also discussed.</description><subject>Animals</subject><subject>Axon</subject><subject>Biological and medical sciences</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Microfluidic</subject><subject>Microfluidic Analytical Techniques - trends</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Nanotechnology</subject><subject>Nanotechnology - trends</subject><subject>Neurology</subject><subject>Neuron</subject><subject>Neurons - physiology</subject><subject>Neurosciences - instrumentation</subject><subject>Neurosciences - trends</subject><subject>PDMS</subject><subject>Single cell</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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| ispartof | Journal of the neurological sciences, 2007-01, Vol.252 (2), p.135-143 |
| issn | 0022-510X 1878-5883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Axon Biological and medical sciences Human viral diseases Humans Infectious diseases Medical sciences Microfluidic Microfluidic Analytical Techniques - trends Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Nanotechnology Nanotechnology - trends Neurology Neuron Neurons - physiology Neurosciences - instrumentation Neurosciences - trends PDMS Single cell Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Applications of microfluidics for neuronal studies |
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