Spectrum of epithelial cell abnormalities of uterine cervix in a cervical cancer screening programme: Implications for resource limited settings
Abstract Objective (1) To compute the frequencies and peak age incidences of epithelial cell abnormalities (ECA) of uterine cervix in a cytology-based screening programme and (2) to analyze the comparative frequencies of squamous intraepithelial lesions (SIL) and malignancies in age groups
Gespeichert in:
| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2007-10, Vol.134 (2), p.238-242 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 242 |
|---|---|
| container_issue | 2 |
| container_start_page | 238 |
| container_title | European journal of obstetrics & gynecology and reproductive biology |
| container_volume | 134 |
| creator | Gupta, Sanjay Sodhani, Pushpa Halder, Kaushik Chachra, Krishan Lal Sardana, Sarita Singh, Veena Sehgal, Ashok |
| description | Abstract Objective (1) To compute the frequencies and peak age incidences of epithelial cell abnormalities (ECA) of uterine cervix in a cytology-based screening programme and (2) to analyze the comparative frequencies of squamous intraepithelial lesions (SIL) and malignancies in age groups |
| doi_str_mv | 10.1016/j.ejogrb.2006.07.022 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68420568</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0301211506004088</els_id><sourcerecordid>68420568</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-6f237c7006cbe8dcc5e07b2716c8cf8ce703172f1a670ee50940daf43e74171a3</originalsourceid><addsrcrecordid>eNqFksGK1TAUhoMozp3RNxDJRnetJ2ma9LoQZNBxYMDF6Dqk6emY2qY1SQfnLXxkU3phwI3ZJJDvP5zz_4eQVwxKBky-G0oc5rvQlhxAlqBK4PwJObBG8ULJWjwlB6iAFZyx-oycxzhAPlV1fE7OmDxy4KI5kD-3C9oU1onOPcXFpR84OjNSi-NITevnMJnRJYdxA9aEwXnMv-He_abOU7O_7SYxPr9ptAHRO39Hl5D7M9OE7-n1tIwZSm72kfZzoAHjvAaLdHSTS9jRiCllUXxBnvVmjPjydF-Q758_fbv8Utx8vbq-_HhTWCHqVMieV8qqPLptsemsrRFUyxWTtrF9Y1FBxRTvmZEKEGs4CuhMLypUgilmqgvydq-bu_y1Ykx6cnGb2nic16hlIzjUssmg2EEb5hgD9noJbjLhQTPQWxJ60HsSektCg9I5iSx7faq_thN2j6KT9Rl4cwJMzPb1Idvn4iN3ZHUlBcvch53D7Ma9w6CjdZit7lzI0eludv_r5N8CdnR-i-wnPmAccg4-O62ZjlyDvt22ZlsakAACmqb6CyhKwM0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68420568</pqid></control><display><type>article</type><title>Spectrum of epithelial cell abnormalities of uterine cervix in a cervical cancer screening programme: Implications for resource limited settings</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Gupta, Sanjay ; Sodhani, Pushpa ; Halder, Kaushik ; Chachra, Krishan Lal ; Sardana, Sarita ; Singh, Veena ; Sehgal, Ashok</creator><creatorcontrib>Gupta, Sanjay ; Sodhani, Pushpa ; Halder, Kaushik ; Chachra, Krishan Lal ; Sardana, Sarita ; Singh, Veena ; Sehgal, Ashok</creatorcontrib><description>Abstract Objective (1) To compute the frequencies and peak age incidences of epithelial cell abnormalities (ECA) of uterine cervix in a cytology-based screening programme and (2) to analyze the comparative frequencies of squamous intraepithelial lesions (SIL) and malignancies in age groups <40 and ≥40 years, in order to assess the implications for screening protocol in resource limited settings. Study design Pap smears form 29,475 women were cytologically screened over a 4-year period as a part of hospital-based screening programme. The frequencies, peak age incidences and mean age of various ECA detected were computed. The data was further stratified in to age groups <40 (Gp 1) and ≥40 (Gp 2) and comparative profile of the lesions was analyzed. Results On cytologic screening of the smears 5.6% ECA were detected. Atypical squamous cells-undetermined significance (ASC-US) and low grade SILs (LSIL) were diagnosed more frequently in Gp 1 ( p < 0.001) while atypical glandular cells (AGC) and malignancies were more significantly more frequent in Gp 2 ( p < 0.001). The frequency of HSIL was similar in the two groups. The SILs predominated in the fourth decade while the malignant lesions were most frequent in age >50 years. The mean age for LSIL and HSIL was 34.7 and 37.7 years, respectively, while for malignancy it was 51.8 years thus corroborating the hypothesis that a prolonged latent phase exists between the precursor lesions and the onset of invasive cancer. Conclusions Since the goal of any screening programme should be to pick up majority of the precursor lesions and not frank cancers, it is desirable to initiate screening before 40 years of age. The WHO recommendation of once in a life time screening between 35 and 40 years of age seems appropriate for resource limited settings like ours.</description><identifier>ISSN: 0301-2115</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2006.07.022</identifier><identifier>PMID: 16920248</identifier><identifier>CODEN: EOGRAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Atypical squamous cells (ASC) ; Biological and medical sciences ; Cervical cancer ; Cervical Intraepithelial Neoplasia - diagnosis ; Cervical Intraepithelial Neoplasia - epidemiology ; Cervix Uteri - pathology ; Developing Countries - economics ; Epithelial cell abnormalities (ECA) ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Health Care Rationing - economics ; Humans ; India - epidemiology ; Mass Screening - economics ; Mass Screening - methods ; Medical sciences ; Middle Aged ; Obstetrics and Gynecology ; Papanicolaou Test ; Prevalence ; Screening ; Squamous intraepithelial lesion (SIL) ; Tumors ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - epidemiology ; Vaginal Smears - economics</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2007-10, Vol.134 (2), p.238-242</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2006 Elsevier Ireland Ltd</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-6f237c7006cbe8dcc5e07b2716c8cf8ce703172f1a670ee50940daf43e74171a3</citedby><cites>FETCH-LOGICAL-c445t-6f237c7006cbe8dcc5e07b2716c8cf8ce703172f1a670ee50940daf43e74171a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301211506004088$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19153641$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16920248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gupta, Sanjay</creatorcontrib><creatorcontrib>Sodhani, Pushpa</creatorcontrib><creatorcontrib>Halder, Kaushik</creatorcontrib><creatorcontrib>Chachra, Krishan Lal</creatorcontrib><creatorcontrib>Sardana, Sarita</creatorcontrib><creatorcontrib>Singh, Veena</creatorcontrib><creatorcontrib>Sehgal, Ashok</creatorcontrib><title>Spectrum of epithelial cell abnormalities of uterine cervix in a cervical cancer screening programme: Implications for resource limited settings</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>Abstract Objective (1) To compute the frequencies and peak age incidences of epithelial cell abnormalities (ECA) of uterine cervix in a cytology-based screening programme and (2) to analyze the comparative frequencies of squamous intraepithelial lesions (SIL) and malignancies in age groups <40 and ≥40 years, in order to assess the implications for screening protocol in resource limited settings. Study design Pap smears form 29,475 women were cytologically screened over a 4-year period as a part of hospital-based screening programme. The frequencies, peak age incidences and mean age of various ECA detected were computed. The data was further stratified in to age groups <40 (Gp 1) and ≥40 (Gp 2) and comparative profile of the lesions was analyzed. Results On cytologic screening of the smears 5.6% ECA were detected. Atypical squamous cells-undetermined significance (ASC-US) and low grade SILs (LSIL) were diagnosed more frequently in Gp 1 ( p < 0.001) while atypical glandular cells (AGC) and malignancies were more significantly more frequent in Gp 2 ( p < 0.001). The frequency of HSIL was similar in the two groups. The SILs predominated in the fourth decade while the malignant lesions were most frequent in age >50 years. The mean age for LSIL and HSIL was 34.7 and 37.7 years, respectively, while for malignancy it was 51.8 years thus corroborating the hypothesis that a prolonged latent phase exists between the precursor lesions and the onset of invasive cancer. Conclusions Since the goal of any screening programme should be to pick up majority of the precursor lesions and not frank cancers, it is desirable to initiate screening before 40 years of age. The WHO recommendation of once in a life time screening between 35 and 40 years of age seems appropriate for resource limited settings like ours.</description><subject>Adult</subject><subject>Atypical squamous cells (ASC)</subject><subject>Biological and medical sciences</subject><subject>Cervical cancer</subject><subject>Cervical Intraepithelial Neoplasia - diagnosis</subject><subject>Cervical Intraepithelial Neoplasia - epidemiology</subject><subject>Cervix Uteri - pathology</subject><subject>Developing Countries - economics</subject><subject>Epithelial cell abnormalities (ECA)</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Health Care Rationing - economics</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Mass Screening - economics</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Obstetrics and Gynecology</subject><subject>Papanicolaou Test</subject><subject>Prevalence</subject><subject>Screening</subject><subject>Squamous intraepithelial lesion (SIL)</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Vaginal Smears - economics</subject><issn>0301-2115</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksGK1TAUhoMozp3RNxDJRnetJ2ma9LoQZNBxYMDF6Dqk6emY2qY1SQfnLXxkU3phwI3ZJJDvP5zz_4eQVwxKBky-G0oc5rvQlhxAlqBK4PwJObBG8ULJWjwlB6iAFZyx-oycxzhAPlV1fE7OmDxy4KI5kD-3C9oU1onOPcXFpR84OjNSi-NITevnMJnRJYdxA9aEwXnMv-He_abOU7O_7SYxPr9ptAHRO39Hl5D7M9OE7-n1tIwZSm72kfZzoAHjvAaLdHSTS9jRiCllUXxBnvVmjPjydF-Q758_fbv8Utx8vbq-_HhTWCHqVMieV8qqPLptsemsrRFUyxWTtrF9Y1FBxRTvmZEKEGs4CuhMLypUgilmqgvydq-bu_y1Ykx6cnGb2nic16hlIzjUssmg2EEb5hgD9noJbjLhQTPQWxJ60HsSektCg9I5iSx7faq_thN2j6KT9Rl4cwJMzPb1Idvn4iN3ZHUlBcvch53D7Ma9w6CjdZit7lzI0eludv_r5N8CdnR-i-wnPmAccg4-O62ZjlyDvt22ZlsakAACmqb6CyhKwM0</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Gupta, Sanjay</creator><creator>Sodhani, Pushpa</creator><creator>Halder, Kaushik</creator><creator>Chachra, Krishan Lal</creator><creator>Sardana, Sarita</creator><creator>Singh, Veena</creator><creator>Sehgal, Ashok</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Spectrum of epithelial cell abnormalities of uterine cervix in a cervical cancer screening programme: Implications for resource limited settings</title><author>Gupta, Sanjay ; Sodhani, Pushpa ; Halder, Kaushik ; Chachra, Krishan Lal ; Sardana, Sarita ; Singh, Veena ; Sehgal, Ashok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-6f237c7006cbe8dcc5e07b2716c8cf8ce703172f1a670ee50940daf43e74171a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Atypical squamous cells (ASC)</topic><topic>Biological and medical sciences</topic><topic>Cervical cancer</topic><topic>Cervical Intraepithelial Neoplasia - diagnosis</topic><topic>Cervical Intraepithelial Neoplasia - epidemiology</topic><topic>Cervix Uteri - pathology</topic><topic>Developing Countries - economics</topic><topic>Epithelial cell abnormalities (ECA)</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Health Care Rationing - economics</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Mass Screening - economics</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Obstetrics and Gynecology</topic><topic>Papanicolaou Test</topic><topic>Prevalence</topic><topic>Screening</topic><topic>Squamous intraepithelial lesion (SIL)</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Vaginal Smears - economics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Sanjay</creatorcontrib><creatorcontrib>Sodhani, Pushpa</creatorcontrib><creatorcontrib>Halder, Kaushik</creatorcontrib><creatorcontrib>Chachra, Krishan Lal</creatorcontrib><creatorcontrib>Sardana, Sarita</creatorcontrib><creatorcontrib>Singh, Veena</creatorcontrib><creatorcontrib>Sehgal, Ashok</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Sanjay</au><au>Sodhani, Pushpa</au><au>Halder, Kaushik</au><au>Chachra, Krishan Lal</au><au>Sardana, Sarita</au><au>Singh, Veena</au><au>Sehgal, Ashok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spectrum of epithelial cell abnormalities of uterine cervix in a cervical cancer screening programme: Implications for resource limited settings</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>134</volume><issue>2</issue><spage>238</spage><epage>242</epage><pages>238-242</pages><issn>0301-2115</issn><eissn>1872-7654</eissn><coden>EOGRAL</coden><abstract>Abstract Objective (1) To compute the frequencies and peak age incidences of epithelial cell abnormalities (ECA) of uterine cervix in a cytology-based screening programme and (2) to analyze the comparative frequencies of squamous intraepithelial lesions (SIL) and malignancies in age groups <40 and ≥40 years, in order to assess the implications for screening protocol in resource limited settings. Study design Pap smears form 29,475 women were cytologically screened over a 4-year period as a part of hospital-based screening programme. The frequencies, peak age incidences and mean age of various ECA detected were computed. The data was further stratified in to age groups <40 (Gp 1) and ≥40 (Gp 2) and comparative profile of the lesions was analyzed. Results On cytologic screening of the smears 5.6% ECA were detected. Atypical squamous cells-undetermined significance (ASC-US) and low grade SILs (LSIL) were diagnosed more frequently in Gp 1 ( p < 0.001) while atypical glandular cells (AGC) and malignancies were more significantly more frequent in Gp 2 ( p < 0.001). The frequency of HSIL was similar in the two groups. The SILs predominated in the fourth decade while the malignant lesions were most frequent in age >50 years. The mean age for LSIL and HSIL was 34.7 and 37.7 years, respectively, while for malignancy it was 51.8 years thus corroborating the hypothesis that a prolonged latent phase exists between the precursor lesions and the onset of invasive cancer. Conclusions Since the goal of any screening programme should be to pick up majority of the precursor lesions and not frank cancers, it is desirable to initiate screening before 40 years of age. The WHO recommendation of once in a life time screening between 35 and 40 years of age seems appropriate for resource limited settings like ours.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>16920248</pmid><doi>10.1016/j.ejogrb.2006.07.022</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-2115 |
| ispartof | European journal of obstetrics & gynecology and reproductive biology, 2007-10, Vol.134 (2), p.238-242 |
| issn | 0301-2115 1872-7654 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68420568 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Atypical squamous cells (ASC) Biological and medical sciences Cervical cancer Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - epidemiology Cervix Uteri - pathology Developing Countries - economics Epithelial cell abnormalities (ECA) Female Female genital diseases Gynecology. Andrology. Obstetrics Health Care Rationing - economics Humans India - epidemiology Mass Screening - economics Mass Screening - methods Medical sciences Middle Aged Obstetrics and Gynecology Papanicolaou Test Prevalence Screening Squamous intraepithelial lesion (SIL) Tumors Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - epidemiology Vaginal Smears - economics |
| title | Spectrum of epithelial cell abnormalities of uterine cervix in a cervical cancer screening programme: Implications for resource limited settings |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T10%3A25%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Spectrum%20of%20epithelial%20cell%20abnormalities%20of%20uterine%20cervix%20in%20a%20cervical%20cancer%20screening%20programme:%20Implications%20for%20resource%20limited%20settings&rft.jtitle=European%20journal%20of%20obstetrics%20&%20gynecology%20and%20reproductive%20biology&rft.au=Gupta,%20Sanjay&rft.date=2007-10-01&rft.volume=134&rft.issue=2&rft.spage=238&rft.epage=242&rft.pages=238-242&rft.issn=0301-2115&rft.eissn=1872-7654&rft.coden=EOGRAL&rft_id=info:doi/10.1016/j.ejogrb.2006.07.022&rft_dat=%3Cproquest_cross%3E68420568%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68420568&rft_id=info:pmid/16920248&rft_els_id=S0301211506004088&rfr_iscdi=true |