Crystal Structure Analysis and Solution Studies of Human Lck-SH3; Zinc-induced Homodimerization Competes with the Binding of Proline-rich Motifs

In cytosolic Src-type tyrosine kinases the Src-type homology 3 (SH3) domain binds to an internal proline-rich motif and the presence or the absence of this interaction modulates the kinase enzymatic activity. The Src-type kinase Lck plays an important role during T-cell activation and development, s...

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Veröffentlicht in:	Journal of molecular biology 2007-02, Vol.365 (5), p.1417-1428
Hauptverfasser:	Romir, Johannes, Lilie, Hauke, Egerer-Sieber, Claudia, Bauer, Finn, Sticht, Heinrich, Muller, Yves A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Binding, Competitive - drug effects Crystallography, X-Ray Dimerization Enzyme Activation - drug effects Humans ligand competition Ligands Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - chemistry Models, Biological Models, Molecular Molecular Sequence Data Proline - metabolism Protein Binding - drug effects Protein Structure, Quaternary - drug effects Protein Structure, Secondary - drug effects SH3 domain Solutions Solvents src Homology Domains Src-type tyrosine kinase T-cell activation Zinc - pharmacology
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