Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS

Transforming growth factor beta1 (TGFbeta1) is a pleiotropic cytokine with potent neurotrophic and immunosuppressive properties that is upregulated after injury, but also expressed in the normal nervous system. In the current study, we examined the regulation of TGFbeta1 and the effects of TGFbeta1...

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Veröffentlicht in:	The Journal of neuroscience 2007-10, Vol.27 (42), p.11201-11213
Hauptverfasser:	Makwana, Milan, Jones, Leonard L, Cuthill, Dan, Heuer, Heike, Bohatschek, Marion, Hristova, Mariya, Friedrichsen, Sönke, Ormsby, Ilona, Bueringer, Dietmute, Koppius, Andrea, Bauer, Karl, Doetschman, Thomas, Raivich, Gennadij
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Brain - metabolism Brain - pathology Brain - physiology Cell Survival - physiology Central Nervous System - cytology Central Nervous System - metabolism Central Nervous System - pathology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Inflammation Mediators - physiology Mice Mice, Transgenic Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - prevention & control Transforming Growth Factor beta1 - physiology
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