Risk Factors for Methicillin-Resistant Staphylococcus aureus (MRSA) and Use of a Nasal Mupirocin Ointment in Oral Cancer Inpatients
Purpose Elimination of methicillin-resistant Staphylococcus aureus (MRSA) is of critical importance in oral and maxillofacial surgery because control is very difficult once infection of an oral tumor or oral wound with MRSA is established. Patients and Methods We retrospectively investigated the ris...
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| Veröffentlicht in: | Journal of oral and maxillofacial surgery 2007-11, Vol.65 (11), p.2159-2163 |
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| creator | Miyake, Minoru, DDS, PhD Ohbayashi, Yumiko, DDS, PhD Iwasaki, Akinori, DDS, PhD Ogawa, Takaaki, DDS, PhD Nagahata, Shunichiro, DDS, PhD |
| description | Purpose Elimination of methicillin-resistant Staphylococcus aureus (MRSA) is of critical importance in oral and maxillofacial surgery because control is very difficult once infection of an oral tumor or oral wound with MRSA is established. Patients and Methods We retrospectively investigated the risk factors for acquiring MRSA in 518 patients with oral cancer among 1,877 inpatients in our department between 1984 and 2005. Results The patients with oral cancer demonstrated a high rate of MRSA colonization and infection (77.8%) relative to the population as a whole with MRSA isolated percentage in our department after 1991. The risk factors for MRSA in oral cancer patients are also related to systemic diseases and physiological and iatrogenic conditions, including cerebrovascular diseases (77.8%), peripheral arterial catheterization (69.2%), diabetes (50.0%), tracheotomy (50.0%), renal failure (50.0%), long-term broad-spectrum antibiotic use (45.7%), and malnutrition (43.3%). However, the highest risk of MRSA seems to be related to poor hygienic care. Conclusions Beginning in 1999, we implemented a strategy for reducing infection by MRSA that included nasal mupirocin ointment for patients at high risk of MRSA; since then, the detection rate has decreased. We suggest that the administration of nasal mupirocin ointment and provision of scrupulous hygienic care for high-risk patients are useful and effective measures for decreasing the incidence of MRSA infection. |
| doi_str_mv | 10.1016/j.joms.2007.04.026 |
| format | Article |
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Patients and Methods We retrospectively investigated the risk factors for acquiring MRSA in 518 patients with oral cancer among 1,877 inpatients in our department between 1984 and 2005. Results The patients with oral cancer demonstrated a high rate of MRSA colonization and infection (77.8%) relative to the population as a whole with MRSA isolated percentage in our department after 1991. The risk factors for MRSA in oral cancer patients are also related to systemic diseases and physiological and iatrogenic conditions, including cerebrovascular diseases (77.8%), peripheral arterial catheterization (69.2%), diabetes (50.0%), tracheotomy (50.0%), renal failure (50.0%), long-term broad-spectrum antibiotic use (45.7%), and malnutrition (43.3%). However, the highest risk of MRSA seems to be related to poor hygienic care. Conclusions Beginning in 1999, we implemented a strategy for reducing infection by MRSA that included nasal mupirocin ointment for patients at high risk of MRSA; since then, the detection rate has decreased. We suggest that the administration of nasal mupirocin ointment and provision of scrupulous hygienic care for high-risk patients are useful and effective measures for decreasing the incidence of MRSA infection.</description><identifier>ISSN: 0278-2391</identifier><identifier>EISSN: 1531-5053</identifier><identifier>DOI: 10.1016/j.joms.2007.04.026</identifier><identifier>PMID: 17954308</identifier><identifier>CODEN: JOMSDA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Intranasal ; Anti-Bacterial Agents - administration & dosage ; Antibacterial agents ; Antibiotic Prophylaxis ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial diseases ; Biological and medical sciences ; Catheterization, Peripheral - instrumentation ; Cerebrovascular Disorders - complications ; Colony Count, Microbial ; Dentistry ; Diabetes Complications - microbiology ; Follow-Up Studies ; Human bacterial diseases ; Humans ; Hygiene ; Infectious diseases ; Malnutrition - complications ; Medical sciences ; Methicillin Resistance ; Mouth Neoplasms - microbiology ; Mupirocin - administration & dosage ; Ointments ; Otorhinolaryngology. Stomatology ; Pharmacology. Drug treatments ; Renal Insufficiency - complications ; Retrospective Studies ; Risk Factors ; Staphylococcal Infections - complications ; Staphylococcal Infections - prevention & control ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Staphylococcus aureus ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - growth & development ; Surgery ; Tracheotomy ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of oral and maxillofacial surgery, 2007-11, Vol.65 (11), p.2159-2163</ispartof><rights>American Association of Oral and Maxillofacial Surgeons</rights><rights>2007 American Association of Oral and Maxillofacial Surgeons</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-f7f5f3b8d02b2322af2af16de4cccaa0699ff5a1dbe0d68e3feee17bd7172db93</citedby><cites>FETCH-LOGICAL-c470t-f7f5f3b8d02b2322af2af16de4cccaa0699ff5a1dbe0d68e3feee17bd7172db93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.joms.2007.04.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19218545$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17954308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyake, Minoru, DDS, PhD</creatorcontrib><creatorcontrib>Ohbayashi, Yumiko, DDS, PhD</creatorcontrib><creatorcontrib>Iwasaki, Akinori, DDS, PhD</creatorcontrib><creatorcontrib>Ogawa, Takaaki, DDS, PhD</creatorcontrib><creatorcontrib>Nagahata, Shunichiro, DDS, PhD</creatorcontrib><title>Risk Factors for Methicillin-Resistant Staphylococcus aureus (MRSA) and Use of a Nasal Mupirocin Ointment in Oral Cancer Inpatients</title><title>Journal of oral and maxillofacial surgery</title><addtitle>J Oral Maxillofac Surg</addtitle><description>Purpose Elimination of methicillin-resistant Staphylococcus aureus (MRSA) is of critical importance in oral and maxillofacial surgery because control is very difficult once infection of an oral tumor or oral wound with MRSA is established. Patients and Methods We retrospectively investigated the risk factors for acquiring MRSA in 518 patients with oral cancer among 1,877 inpatients in our department between 1984 and 2005. Results The patients with oral cancer demonstrated a high rate of MRSA colonization and infection (77.8%) relative to the population as a whole with MRSA isolated percentage in our department after 1991. The risk factors for MRSA in oral cancer patients are also related to systemic diseases and physiological and iatrogenic conditions, including cerebrovascular diseases (77.8%), peripheral arterial catheterization (69.2%), diabetes (50.0%), tracheotomy (50.0%), renal failure (50.0%), long-term broad-spectrum antibiotic use (45.7%), and malnutrition (43.3%). However, the highest risk of MRSA seems to be related to poor hygienic care. Conclusions Beginning in 1999, we implemented a strategy for reducing infection by MRSA that included nasal mupirocin ointment for patients at high risk of MRSA; since then, the detection rate has decreased. We suggest that the administration of nasal mupirocin ointment and provision of scrupulous hygienic care for high-risk patients are useful and effective measures for decreasing the incidence of MRSA infection.</description><subject>Administration, Intranasal</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Antibacterial agents</subject><subject>Antibiotic Prophylaxis</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Catheterization, Peripheral - instrumentation</subject><subject>Cerebrovascular Disorders - complications</subject><subject>Colony Count, Microbial</subject><subject>Dentistry</subject><subject>Diabetes Complications - microbiology</subject><subject>Follow-Up Studies</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Infectious diseases</subject><subject>Malnutrition - complications</subject><subject>Medical sciences</subject><subject>Methicillin Resistance</subject><subject>Mouth Neoplasms - microbiology</subject><subject>Mupirocin - administration & dosage</subject><subject>Ointments</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pharmacology. Drug treatments</subject><subject>Renal Insufficiency - complications</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Staphylococcal Infections - complications</subject><subject>Staphylococcal Infections - prevention & control</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - growth & development</subject><subject>Surgery</subject><subject>Tracheotomy</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0278-2391</issn><issn>1531-5053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAQgIso3nn6B3yQvCj60HWStE0LIhyLpwe3Hux6zyFNJ1z2us2aaYV99o-bsgsHPigEJjDfTMJ8k2WvOSw48OrjdrENO1oIALWAYgGiepKd81LyvIRSPs3OQag6F7LhZ9kLoi0A56WqnmdnXDVlIaE-z36vPT2wK2PHEIm5ENkKx3tvfd_7IV8jeRrNMLLNaPb3hz7YYO1EzEwRU3i_Wm8uPzAzdOyOkAXHDPtuyPRsNe19DNYP7NYP4w5Ti_keU2ppBouRXQ97M_qUoJfZM2d6wleneJHdXX35sfyW39x-vV5e3uS2UDDmTrnSybbuQLRCCmFcOrzqsLDWGgNV0zhXGt61CF1Vo3SIyFXbKa5E1zbyInt37LuP4eeENOqdJ4t9bwYME-mqLnitqv-DAqRqZFElUBxBGwNRRKf30e9MPGgOenakt3p2pGdHGgqdHKWiN6fuU7vD7rHkJCUBb0-AIWt6F9PAPD1yjeB1WZSJ-3TkMA3tl8eoyaaBWux8RDvqLvh__-PzX-U2OffpxQc8IG3DFIekQ3NNQoPezNs0LxMoSEsmlPwDj4PGkA</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Miyake, Minoru, DDS, PhD</creator><creator>Ohbayashi, Yumiko, DDS, PhD</creator><creator>Iwasaki, Akinori, DDS, PhD</creator><creator>Ogawa, Takaaki, DDS, PhD</creator><creator>Nagahata, Shunichiro, DDS, PhD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20071101</creationdate><title>Risk Factors for Methicillin-Resistant Staphylococcus aureus (MRSA) and Use of a Nasal Mupirocin Ointment in Oral Cancer Inpatients</title><author>Miyake, Minoru, DDS, PhD ; Ohbayashi, Yumiko, DDS, PhD ; Iwasaki, Akinori, DDS, PhD ; Ogawa, Takaaki, DDS, PhD ; Nagahata, Shunichiro, DDS, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-f7f5f3b8d02b2322af2af16de4cccaa0699ff5a1dbe0d68e3feee17bd7172db93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Administration, Intranasal</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Antibacterial agents</topic><topic>Antibiotic Prophylaxis</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Catheterization, Peripheral - instrumentation</topic><topic>Cerebrovascular Disorders - complications</topic><topic>Colony Count, Microbial</topic><topic>Dentistry</topic><topic>Diabetes Complications - microbiology</topic><topic>Follow-Up Studies</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Hygiene</topic><topic>Infectious diseases</topic><topic>Malnutrition - complications</topic><topic>Medical sciences</topic><topic>Methicillin Resistance</topic><topic>Mouth Neoplasms - microbiology</topic><topic>Mupirocin - administration & dosage</topic><topic>Ointments</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pharmacology. Drug treatments</topic><topic>Renal Insufficiency - complications</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Staphylococcal Infections - complications</topic><topic>Staphylococcal Infections - prevention & control</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - growth & development</topic><topic>Surgery</topic><topic>Tracheotomy</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyake, Minoru, DDS, PhD</creatorcontrib><creatorcontrib>Ohbayashi, Yumiko, DDS, PhD</creatorcontrib><creatorcontrib>Iwasaki, Akinori, DDS, PhD</creatorcontrib><creatorcontrib>Ogawa, Takaaki, DDS, PhD</creatorcontrib><creatorcontrib>Nagahata, Shunichiro, DDS, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyake, Minoru, DDS, PhD</au><au>Ohbayashi, Yumiko, DDS, PhD</au><au>Iwasaki, Akinori, DDS, PhD</au><au>Ogawa, Takaaki, DDS, PhD</au><au>Nagahata, Shunichiro, DDS, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Methicillin-Resistant Staphylococcus aureus (MRSA) and Use of a Nasal Mupirocin Ointment in Oral Cancer Inpatients</atitle><jtitle>Journal of oral and maxillofacial surgery</jtitle><addtitle>J Oral Maxillofac Surg</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>65</volume><issue>11</issue><spage>2159</spage><epage>2163</epage><pages>2159-2163</pages><issn>0278-2391</issn><eissn>1531-5053</eissn><coden>JOMSDA</coden><abstract>Purpose Elimination of methicillin-resistant Staphylococcus aureus (MRSA) is of critical importance in oral and maxillofacial surgery because control is very difficult once infection of an oral tumor or oral wound with MRSA is established. Patients and Methods We retrospectively investigated the risk factors for acquiring MRSA in 518 patients with oral cancer among 1,877 inpatients in our department between 1984 and 2005. Results The patients with oral cancer demonstrated a high rate of MRSA colonization and infection (77.8%) relative to the population as a whole with MRSA isolated percentage in our department after 1991. The risk factors for MRSA in oral cancer patients are also related to systemic diseases and physiological and iatrogenic conditions, including cerebrovascular diseases (77.8%), peripheral arterial catheterization (69.2%), diabetes (50.0%), tracheotomy (50.0%), renal failure (50.0%), long-term broad-spectrum antibiotic use (45.7%), and malnutrition (43.3%). However, the highest risk of MRSA seems to be related to poor hygienic care. Conclusions Beginning in 1999, we implemented a strategy for reducing infection by MRSA that included nasal mupirocin ointment for patients at high risk of MRSA; since then, the detection rate has decreased. We suggest that the administration of nasal mupirocin ointment and provision of scrupulous hygienic care for high-risk patients are useful and effective measures for decreasing the incidence of MRSA infection.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17954308</pmid><doi>10.1016/j.joms.2007.04.026</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of oral and maxillofacial surgery, 2007-11, Vol.65 (11), p.2159-2163 |
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| subjects | Administration, Intranasal Anti-Bacterial Agents - administration & dosage Antibacterial agents Antibiotic Prophylaxis Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial diseases Biological and medical sciences Catheterization, Peripheral - instrumentation Cerebrovascular Disorders - complications Colony Count, Microbial Dentistry Diabetes Complications - microbiology Follow-Up Studies Human bacterial diseases Humans Hygiene Infectious diseases Malnutrition - complications Medical sciences Methicillin Resistance Mouth Neoplasms - microbiology Mupirocin - administration & dosage Ointments Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Renal Insufficiency - complications Retrospective Studies Risk Factors Staphylococcal Infections - complications Staphylococcal Infections - prevention & control Staphylococcal infections, streptococcal infections, pneumococcal infections Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Surgery Tracheotomy Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Risk Factors for Methicillin-Resistant Staphylococcus aureus (MRSA) and Use of a Nasal Mupirocin Ointment in Oral Cancer Inpatients |
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