Adhesion Molecule Polymorphisms in Acute Renal Allograft Rejection
Abstract Acute rejection is the main cause of early renal allograft failure. Adhesion molecules provide signals for activation and recruitment of effector cells leading to graft infiltration by host T cells, which are key to allograft rejection. This study was undertaken to analyze the adhesion mole...
Gespeichert in:
| Veröffentlicht in: | Transplantation proceedings 2007-10, Vol.39 (8), p.2563-2564 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2564 |
|---|---|
| container_issue | 8 |
| container_start_page | 2563 |
| container_title | Transplantation proceedings |
| container_volume | 39 |
| creator | Khazen, D Jendoubi-Ayed, S Gorgi, Y Sfar, I Abderrahim, E Ben Abdallah, T Ayed, K |
| description | Abstract Acute rejection is the main cause of early renal allograft failure. Adhesion molecules provide signals for activation and recruitment of effector cells leading to graft infiltration by host T cells, which are key to allograft rejection. This study was undertaken to analyze the adhesion molecule gene polymorphisms in renal transplant recipients and to investigate their potential association with the development of acute allograft rejection. A total of 120 renal transplant recipients and 100 controls were retrospectively genotyped. Seven nucleotide polymorphisms in intracellular adhesion molecule (ICAM)-1, platelet endothelial cell adhesion molecule (PECAM)-1, L-selectin, and E-selectin were analyzed using allele-specific polymerase chain reaction (PCR)-SSP assay and PCR–restriction fragment length polymorphism (RFLP). Recipients were selected on the basis of the development of acute allograft rejection in the first 6 months after renal transplantation. Forty-one patients developed acute allograft rejection and 79 showed uneventful courses. There was no evidence for an association of any polymorphism with acute rejection. Thus, we concluded that these genes do not predispose to acute renal allograft rejection. |
| doi_str_mv | 10.1016/j.transproceed.2007.08.031 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68418659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0041134507009505</els_id><sourcerecordid>68418659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c463t-6cdbee4c7e1571b3b7f03d0f7288f4095a783eb7f2154ccd22fee0e52bd95f813</originalsourceid><addsrcrecordid>eNqNkVuL1DAUgIMo7rj6F6QI-tbuyaVN6oMwrpcVdlG8PIc0PXVT02ZMWmH-vRlmUPFpn8JJvnPJdwh5RqGiQJuLsVqimdMuBovYVwxAVqAq4PQe2VAleckaxu-TDYCgJeWiPiOPUhohx0zwh-SMyrYWVIoNeb3tbzG5MBc3waNdPRafgt9PIe5uXZpS4eZia9cFi884G19svQ_foxmWHI9ol5z5mDwYjE_45HSek2_v3n69vCqvP77_cLm9Lq1o-FI2tu8QhZVIa0k73skBeA-DZEoNAtraSMUx3zJaC2t7xgZEwJp1fVsPivJz8uJYN3_854pp0ZNLFr03M4Y16UYJqpq6zeDLI2hjSCnioHfRTSbuNQV9MKhH_a9BfTCoQelsMCc_PXVZuym__Uk9KcvA8xNgkjV-yIWsS3-5lgFTrMncmyOH2ckvh1En63C22LuYxek-uLvN8-q_Mta72eXOP3CPaQxrzHtJmurENOgvh50fVg4SslOo-W_iV6sn</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68418659</pqid></control><display><type>article</type><title>Adhesion Molecule Polymorphisms in Acute Renal Allograft Rejection</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Khazen, D ; Jendoubi-Ayed, S ; Gorgi, Y ; Sfar, I ; Abderrahim, E ; Ben Abdallah, T ; Ayed, K</creator><creatorcontrib>Khazen, D ; Jendoubi-Ayed, S ; Gorgi, Y ; Sfar, I ; Abderrahim, E ; Ben Abdallah, T ; Ayed, K</creatorcontrib><description>Abstract Acute rejection is the main cause of early renal allograft failure. Adhesion molecules provide signals for activation and recruitment of effector cells leading to graft infiltration by host T cells, which are key to allograft rejection. This study was undertaken to analyze the adhesion molecule gene polymorphisms in renal transplant recipients and to investigate their potential association with the development of acute allograft rejection. A total of 120 renal transplant recipients and 100 controls were retrospectively genotyped. Seven nucleotide polymorphisms in intracellular adhesion molecule (ICAM)-1, platelet endothelial cell adhesion molecule (PECAM)-1, L-selectin, and E-selectin were analyzed using allele-specific polymerase chain reaction (PCR)-SSP assay and PCR–restriction fragment length polymorphism (RFLP). Recipients were selected on the basis of the development of acute allograft rejection in the first 6 months after renal transplantation. Forty-one patients developed acute allograft rejection and 79 showed uneventful courses. There was no evidence for an association of any polymorphism with acute rejection. Thus, we concluded that these genes do not predispose to acute renal allograft rejection.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2007.08.031</identifier><identifier>PMID: 17954174</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Disease ; Adult ; Biological and medical sciences ; Cell Adhesion Molecules - genetics ; Codon ; E-Selectin - genetics ; Exons ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection - genetics ; Humans ; Intercellular Adhesion Molecule-1 - genetics ; Kidney Transplantation - pathology ; L-Selectin - genetics ; Male ; Medical sciences ; Platelet Endothelial Cell Adhesion Molecule-1 - genetics ; Polymorphism, Genetic ; Retrospective Studies ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology</subject><ispartof>Transplantation proceedings, 2007-10, Vol.39 (8), p.2563-2564</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-6cdbee4c7e1571b3b7f03d0f7288f4095a783eb7f2154ccd22fee0e52bd95f813</citedby><cites>FETCH-LOGICAL-c463t-6cdbee4c7e1571b3b7f03d0f7288f4095a783eb7f2154ccd22fee0e52bd95f813</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0041134507009505$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19202826$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17954174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khazen, D</creatorcontrib><creatorcontrib>Jendoubi-Ayed, S</creatorcontrib><creatorcontrib>Gorgi, Y</creatorcontrib><creatorcontrib>Sfar, I</creatorcontrib><creatorcontrib>Abderrahim, E</creatorcontrib><creatorcontrib>Ben Abdallah, T</creatorcontrib><creatorcontrib>Ayed, K</creatorcontrib><title>Adhesion Molecule Polymorphisms in Acute Renal Allograft Rejection</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Acute rejection is the main cause of early renal allograft failure. Adhesion molecules provide signals for activation and recruitment of effector cells leading to graft infiltration by host T cells, which are key to allograft rejection. This study was undertaken to analyze the adhesion molecule gene polymorphisms in renal transplant recipients and to investigate their potential association with the development of acute allograft rejection. A total of 120 renal transplant recipients and 100 controls were retrospectively genotyped. Seven nucleotide polymorphisms in intracellular adhesion molecule (ICAM)-1, platelet endothelial cell adhesion molecule (PECAM)-1, L-selectin, and E-selectin were analyzed using allele-specific polymerase chain reaction (PCR)-SSP assay and PCR–restriction fragment length polymorphism (RFLP). Recipients were selected on the basis of the development of acute allograft rejection in the first 6 months after renal transplantation. Forty-one patients developed acute allograft rejection and 79 showed uneventful courses. There was no evidence for an association of any polymorphism with acute rejection. Thus, we concluded that these genes do not predispose to acute renal allograft rejection.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Codon</subject><subject>E-Selectin - genetics</subject><subject>Exons</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - genetics</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Kidney Transplantation - pathology</subject><subject>L-Selectin - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVuL1DAUgIMo7rj6F6QI-tbuyaVN6oMwrpcVdlG8PIc0PXVT02ZMWmH-vRlmUPFpn8JJvnPJdwh5RqGiQJuLsVqimdMuBovYVwxAVqAq4PQe2VAleckaxu-TDYCgJeWiPiOPUhohx0zwh-SMyrYWVIoNeb3tbzG5MBc3waNdPRafgt9PIe5uXZpS4eZia9cFi884G19svQ_foxmWHI9ol5z5mDwYjE_45HSek2_v3n69vCqvP77_cLm9Lq1o-FI2tu8QhZVIa0k73skBeA-DZEoNAtraSMUx3zJaC2t7xgZEwJp1fVsPivJz8uJYN3_854pp0ZNLFr03M4Y16UYJqpq6zeDLI2hjSCnioHfRTSbuNQV9MKhH_a9BfTCoQelsMCc_PXVZuym__Uk9KcvA8xNgkjV-yIWsS3-5lgFTrMncmyOH2ckvh1En63C22LuYxek-uLvN8-q_Mta72eXOP3CPaQxrzHtJmurENOgvh50fVg4SslOo-W_iV6sn</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Khazen, D</creator><creator>Jendoubi-Ayed, S</creator><creator>Gorgi, Y</creator><creator>Sfar, I</creator><creator>Abderrahim, E</creator><creator>Ben Abdallah, T</creator><creator>Ayed, K</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>Adhesion Molecule Polymorphisms in Acute Renal Allograft Rejection</title><author>Khazen, D ; Jendoubi-Ayed, S ; Gorgi, Y ; Sfar, I ; Abderrahim, E ; Ben Abdallah, T ; Ayed, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-6cdbee4c7e1571b3b7f03d0f7288f4095a783eb7f2154ccd22fee0e52bd95f813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Codon</topic><topic>E-Selectin - genetics</topic><topic>Exons</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection - genetics</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Kidney Transplantation - pathology</topic><topic>L-Selectin - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khazen, D</creatorcontrib><creatorcontrib>Jendoubi-Ayed, S</creatorcontrib><creatorcontrib>Gorgi, Y</creatorcontrib><creatorcontrib>Sfar, I</creatorcontrib><creatorcontrib>Abderrahim, E</creatorcontrib><creatorcontrib>Ben Abdallah, T</creatorcontrib><creatorcontrib>Ayed, K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khazen, D</au><au>Jendoubi-Ayed, S</au><au>Gorgi, Y</au><au>Sfar, I</au><au>Abderrahim, E</au><au>Ben Abdallah, T</au><au>Ayed, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adhesion Molecule Polymorphisms in Acute Renal Allograft Rejection</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>39</volume><issue>8</issue><spage>2563</spage><epage>2564</epage><pages>2563-2564</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Acute rejection is the main cause of early renal allograft failure. Adhesion molecules provide signals for activation and recruitment of effector cells leading to graft infiltration by host T cells, which are key to allograft rejection. This study was undertaken to analyze the adhesion molecule gene polymorphisms in renal transplant recipients and to investigate their potential association with the development of acute allograft rejection. A total of 120 renal transplant recipients and 100 controls were retrospectively genotyped. Seven nucleotide polymorphisms in intracellular adhesion molecule (ICAM)-1, platelet endothelial cell adhesion molecule (PECAM)-1, L-selectin, and E-selectin were analyzed using allele-specific polymerase chain reaction (PCR)-SSP assay and PCR–restriction fragment length polymorphism (RFLP). Recipients were selected on the basis of the development of acute allograft rejection in the first 6 months after renal transplantation. Forty-one patients developed acute allograft rejection and 79 showed uneventful courses. There was no evidence for an association of any polymorphism with acute rejection. Thus, we concluded that these genes do not predispose to acute renal allograft rejection.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17954174</pmid><doi>10.1016/j.transproceed.2007.08.031</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1345 |
| ispartof | Transplantation proceedings, 2007-10, Vol.39 (8), p.2563-2564 |
| issn | 0041-1345 1873-2623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68418659 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acute Disease Adult Biological and medical sciences Cell Adhesion Molecules - genetics Codon E-Selectin - genetics Exons Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - genetics Humans Intercellular Adhesion Molecule-1 - genetics Kidney Transplantation - pathology L-Selectin - genetics Male Medical sciences Platelet Endothelial Cell Adhesion Molecule-1 - genetics Polymorphism, Genetic Retrospective Studies Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology |
| title | Adhesion Molecule Polymorphisms in Acute Renal Allograft Rejection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T23%3A23%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adhesion%20Molecule%20Polymorphisms%20in%20Acute%20Renal%20Allograft%20Rejection&rft.jtitle=Transplantation%20proceedings&rft.au=Khazen,%20D&rft.date=2007-10-01&rft.volume=39&rft.issue=8&rft.spage=2563&rft.epage=2564&rft.pages=2563-2564&rft.issn=0041-1345&rft.eissn=1873-2623&rft.coden=TRPPA8&rft_id=info:doi/10.1016/j.transproceed.2007.08.031&rft_dat=%3Cproquest_cross%3E68418659%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68418659&rft_id=info:pmid/17954174&rft_els_id=1_s2_0_S0041134507009505&rfr_iscdi=true |