Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells : Involvement of mammalian target of rapamycin/eIF4E pathway

Nitric oxide (NO) in nanomolar (nmol/L) concentrations is consistently detected in tumor microenvironment and has been found to promote tumorigenesis. The mechanism by which NO enhances tumor progression is largely unknown. In this study, we investigated the possible mechanisms and identified cellul...

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