beta1 antagonist and beta2 agonist, celiprolol, restores the impaired endothelial dependent and independent responses and decreased TNFalpha in rat with type II diabetes

The effect of beta antagonists in the diabetic vascular lesion is controversial. We investigated the effect of celiprolol hydrochloride, a beta1 antagonist and mild beta2 agonist, on the lesions and function in type II male Otsuka Long-Evans Tokushima Fatty (OLETF) diabetic rats. OLETF rats were fed...

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Veröffentlicht in:	Life sciences (1973) 2007-01, Vol.80 (6), p.592-599
Hauptverfasser:	Hayashi, Toshio, Juliet, Packiasamy A R, Miyazaki-Akita, Asaka, Funami, Jun, Matsui-Hirai, Hisako, Fukatsu, Akiko, Iguchi, Akihisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-1 Receptor Antagonists Adrenergic beta-2 Receptor Agonists Animals Aorta, Abdominal - metabolism Atherosclerosis - metabolism Atherosclerosis - prevention & control Blood Pressure - drug effects Body Weight - drug effects Celiprolol - pharmacology Celiprolol - therapeutic use Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism Diabetic Angiopathies - metabolism Diabetic Angiopathies - prevention & control Endothelium, Vascular - metabolism Male Nitrates - blood Nitric Oxide - metabolism Nitrites - blood Rats Rats, Long-Evans Superoxides - metabolism Tumor Necrosis Factor-alpha - metabolism
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