The Role of Electrostatics in Colicin Nuclease Domain Translocation into Bacterial Cells

The mechanism(s) by which nuclease colicins translocate distinct cytotoxic enzymes (DNases, rRNases, and tRNases) to the cytoplasm of Escherichia coli is unknown. Previous in vitro investigations on isolated colicin nuclease domains have shown that they have a strong propensity to associate with ani...

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Veröffentlicht in:	The Journal of biological chemistry 2007-10, Vol.282 (43), p.31389-31397
Hauptverfasser:	Walker, Daniel, Mosbahi, Khédidja, Vankemmelbeke, Mireille, James, Richard, Kleanthous, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Death - physiology Cell Survival Colicins - chemistry Colicins - genetics Colicins - isolation & purification Colicins - metabolism Escherichia coli Escherichia coli - metabolism Genes, Reporter Genetic Variation Half-Life Kinetics Luciferases - analysis Luciferases - metabolism Protein Structure, Tertiary Protein Transport Static Electricity Transformation, Genetic
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