Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1
Abstract We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all c...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 2007-01, Vol.172 (2), p.154-157 |
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| creator | de Oliveira, Fábio Morato Tone, Luiz Gonzaga Simões, Belinda Pinto Falcão, Roberto Passetto Brassesco, María Sol Sakamoto-Hojo, Elza Tiemi Silva dos Santos, Guilherme Augusto Marinato, André Fiorin Jácomo, Rafael Henriques Rego, Eduardo Magalhães |
| description | Abstract We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase–polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations. |
| doi_str_mv | 10.1016/j.cancergencyto.2006.09.004 |
| format | Article |
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Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase–polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations.</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/j.cancergencyto.2006.09.004</identifier><identifier>PMID: 17213025</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Chromosomes, Human, Pair 11 - genetics ; Chromosomes, Human, Pair 5 - genetics ; Cyclin D1 - biosynthesis ; Cyclin D1 - genetics ; Gene Expression Regulation, Neoplastic - genetics ; Hematology, Oncology and Palliative Medicine ; Humans ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - metabolism ; Leukemia, Myelomonocytic, Acute ; Male ; Medical Education ; Translocation, Genetic</subject><ispartof>Cancer genetics and cytogenetics, 2007-01, Vol.172 (2), p.154-157</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-8702079b6da9ca13e1b10d99629658b2868643b8b9893c16948ef6fcf94c3c293</citedby><cites>FETCH-LOGICAL-c467t-8702079b6da9ca13e1b10d99629658b2868643b8b9893c16948ef6fcf94c3c293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cancergencyto.2006.09.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17213025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Oliveira, Fábio Morato</creatorcontrib><creatorcontrib>Tone, Luiz Gonzaga</creatorcontrib><creatorcontrib>Simões, Belinda Pinto</creatorcontrib><creatorcontrib>Falcão, Roberto Passetto</creatorcontrib><creatorcontrib>Brassesco, María Sol</creatorcontrib><creatorcontrib>Sakamoto-Hojo, Elza Tiemi</creatorcontrib><creatorcontrib>Silva dos Santos, Guilherme Augusto</creatorcontrib><creatorcontrib>Marinato, André Fiorin</creatorcontrib><creatorcontrib>Jácomo, Rafael Henriques</creatorcontrib><creatorcontrib>Rego, Eduardo Magalhães</creatorcontrib><title>Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Abstract We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase–polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations.</description><subject>Adult</subject><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Chromosomes, Human, Pair 5 - genetics</subject><subject>Cyclin D1 - biosynthesis</subject><subject>Cyclin D1 - genetics</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - metabolism</subject><subject>Leukemia, Myelomonocytic, Acute</subject><subject>Male</subject><subject>Medical Education</subject><subject>Translocation, Genetic</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2L1DAUhoso7rj6FyQgyMxFx5OPpgkDC8O6fsAsXqjgXUjTU81sP2aSVrf_fltmQPRGr3LznOeE9z1J8orCmgKVb_ZrZ1uH4Tu2buy7NQOQa9BrAPEoWVCV81SITD5OFhOdpUKCukiexbgHgJxp-TS5oDmjHFi2SL5t3dAjaUasO1-SGoc7bLwly-3tLr1lK_LL9z9Iv8w2lK6WR55tjpSviG1L0nahsTXB-0PAGH3Xkq4ibnS1b8lb-jx5Utk64ovze5l8fXfz5fpDuvv0_uP1dpc6IfM-VTkwyHUhS6udpRxpQaHUWk4fzVTBlFRS8EIVWmnuqNRCYSUrV2nhuGOaXyavT95D6I4Dxt40Pjqsa9tiN0QjlaBMaPZPkAHLeZbNxs0JdKGLMWBlDsE3NoyGgpkbMHvzRwNmbsCANlMD0_TL85qhaLD8PXuOfAJuTgBOqfz0GEx0fhJh6QO63pSd_89FV3955uS9s_Udjhj33RDaKXhDTWQGzOf5GOZbADlJQEr-AFEOr58</recordid><startdate>20070115</startdate><enddate>20070115</enddate><creator>de Oliveira, Fábio Morato</creator><creator>Tone, Luiz Gonzaga</creator><creator>Simões, Belinda Pinto</creator><creator>Falcão, Roberto Passetto</creator><creator>Brassesco, María Sol</creator><creator>Sakamoto-Hojo, Elza Tiemi</creator><creator>Silva dos Santos, Guilherme Augusto</creator><creator>Marinato, André Fiorin</creator><creator>Jácomo, Rafael Henriques</creator><creator>Rego, Eduardo Magalhães</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070115</creationdate><title>Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1</title><author>de Oliveira, Fábio Morato ; Tone, Luiz Gonzaga ; Simões, Belinda Pinto ; Falcão, Roberto Passetto ; Brassesco, María Sol ; Sakamoto-Hojo, Elza Tiemi ; Silva dos Santos, Guilherme Augusto ; Marinato, André Fiorin ; Jácomo, Rafael Henriques ; Rego, Eduardo Magalhães</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-8702079b6da9ca13e1b10d99629658b2868643b8b9893c16948ef6fcf94c3c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Chromosomes, Human, Pair 11 - genetics</topic><topic>Chromosomes, Human, Pair 5 - genetics</topic><topic>Cyclin D1 - biosynthesis</topic><topic>Cyclin D1 - genetics</topic><topic>Gene Expression Regulation, Neoplastic - genetics</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - metabolism</topic><topic>Leukemia, Myelomonocytic, Acute</topic><topic>Male</topic><topic>Medical Education</topic><topic>Translocation, Genetic</topic><toplevel>online_resources</toplevel><creatorcontrib>de Oliveira, Fábio Morato</creatorcontrib><creatorcontrib>Tone, Luiz Gonzaga</creatorcontrib><creatorcontrib>Simões, Belinda Pinto</creatorcontrib><creatorcontrib>Falcão, Roberto Passetto</creatorcontrib><creatorcontrib>Brassesco, María Sol</creatorcontrib><creatorcontrib>Sakamoto-Hojo, Elza Tiemi</creatorcontrib><creatorcontrib>Silva dos Santos, Guilherme Augusto</creatorcontrib><creatorcontrib>Marinato, André Fiorin</creatorcontrib><creatorcontrib>Jácomo, Rafael Henriques</creatorcontrib><creatorcontrib>Rego, Eduardo Magalhães</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer genetics and cytogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Oliveira, Fábio Morato</au><au>Tone, Luiz Gonzaga</au><au>Simões, Belinda Pinto</au><au>Falcão, Roberto Passetto</au><au>Brassesco, María Sol</au><au>Sakamoto-Hojo, Elza Tiemi</au><au>Silva dos Santos, Guilherme Augusto</au><au>Marinato, André Fiorin</au><au>Jácomo, Rafael Henriques</au><au>Rego, Eduardo Magalhães</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1</atitle><jtitle>Cancer genetics and cytogenetics</jtitle><addtitle>Cancer Genet Cytogenet</addtitle><date>2007-01-15</date><risdate>2007</risdate><volume>172</volume><issue>2</issue><spage>154</spage><epage>157</epage><pages>154-157</pages><issn>0165-4608</issn><eissn>1873-4456</eissn><abstract>Abstract We report a case of acute myeloid leukemia (AML) subtype M2, with t(5;11)(q35;q13), in a 30-year-old man. Conventional cytogenetic, spectral karyotyping, and fluorescence in situ hybridization (FISH) studies on bone marrow sample obtained at diagnosis revealed an abnormal karyotype in all cells examined. FISH analysis demonstrated absence of translocations in the region of the cyclin D1 gene and real-time quantitative reverse transcriptase–polymerase chain reaction revealed normal expression of this gene. Similar to the 11q23 region, 11q13 changes can be found in both myeloid and lymphoid neoplasias with different chromosomes serving as donors in translocations.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17213025</pmid><doi>10.1016/j.cancergencyto.2006.09.004</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 5 - genetics Cyclin D1 - biosynthesis Cyclin D1 - genetics Gene Expression Regulation, Neoplastic - genetics Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myelomonocytic, Acute Male Medical Education Translocation, Genetic |
| title | Acute myeloid leukemia (AML-M2) with t(5;11)(q35;q13) and normal expression of cyclin D1 |
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