Mechanisms involved in the vasodilator effect induced by diosgenin in rat superior mesenteric artery

The aim of this study was to investigate the vasorelaxant effect induced by diosgenin in superior mesenteric rings. In rings pre-contracted with phenylephrine (10μM), diosgenin caused concentration-dependent relaxations [EC 50 = (3.3 ± 1.2) × 10 − 4M, E max = 94.2 ± 2.6 %]. Vascular relaxation induc...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 2007-11, Vol.574 (2), p.172-178
Hauptverfasser:	Dias, Katy Lísias Gondim, Correia, Nadja de Azevedo, Pereira, Krísthea Karyne Gonçalves, Barbosa-Filho, José Maria, Cavalcante, Karla Veruska Marques, Araújo, Islania Giselia Albuquerque, Silva, Darizy Flávia, Guedes, Diego Nunes, Neto, Mario dos Anjos, Bendhack, Lusiane Maria, Medeiros, Isac Almeida
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Diosgenin Diosgenin - pharmacology Dose-Response Relationship, Drug Endothelium-Dependent Relaxing Factors - physiology Intracellular Ca 2 Large-Conductance Calcium-Activated Potassium Channels - physiology Male Medical sciences Mesenteric artery Mesenteric Artery, Superior - drug effects Mesenteric Artery, Superior - physiology Nitric oxide Nitric Oxide - physiology Pharmacology. Drug treatments Phenylephrine - pharmacology Potassium Channel Blockers - pharmacology Prostaglandin-Endoperoxide Synthases - physiology Rats Rats, Wistar Vasodilation Vasodilation - drug effects Vasodilator Agents - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!