Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium
Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than...
Gespeichert in:
| Veröffentlicht in: | Blood 2007-01, Vol.109 (2), p.613-615 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 615 |
|---|---|
| container_issue | 2 |
| container_start_page | 613 |
| container_title | Blood |
| container_volume | 109 |
| creator | Yano, Kiichiro Gale, Daniel Massberg, Steffen Cheruvu, Pavan K. Monahan-Earley, Rita Morgan, Ellen S. Haig, David von Andrian, Ulrich H. Dvorak, Ann M. Aird, William C. |
| description | Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have already been present in this ancestral vertebrate. The goal of this study was to determine whether the hagfish endothelium displays phenotypic heterogeneity. Electron microscopy of the aorta, dermis, heart, and liver revealed ultrastructural heterogeneity of the endothelium. Immunofluorescent studies demonstrated marked differences in lectin binding between vascular beds. Intravital microscopy of the dermis revealed histamine-induced adhesion of leukocytes in capillaries and postcapillary venules, but no such adhesion in arterioles. Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage. |
| doi_str_mv | 10.1182/blood-2006-05-026401 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68411650</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006497120520703</els_id><sourcerecordid>68411650</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-a7e76925ed5df8433b6ba78540c2b450a343885355404dc1ea3e89b9d27042693</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVpaTZp_0EourQ3p6NP25dCCWkSCLSU5ixkaZxV8UpbSV7Yfx9vdiG3ngZmnneYeQi5ZHDFWMe_DlNKvuEAugHVANcS2BuyYop3DQCHt2QFh6HsW3ZGzkv5C8Ck4Oo9OWO670EDW5Hfv9YYU91vg6NrrJjTE0YMdU9DoTZS3KVpriFFm8O0py7FgnmHno5o65yRppHWNVKMPi11CvPmA3k32qngx1O9II8_bv5c3zUPP2_vr78_NE4KXRvbYqt7rtArP3ZSiEEPtu2UBMcHqcAKKbpOCbV0pHcMrcCuH3rPW5Bc9-KCfDnu3eb0b8ZSzSYUh9NkI6a5GN1JxrSCBZRH0OVUSsbRbHPY2Lw3DMzBpXlxaQ4uDShzdLnEPp32z8MG_WvoJG8BPp8AW5ydxmyjC-WVW57qhRIL9-3I4WJjFzCb4gJGhz5kdNX4FP5_yTMTj5K4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68411650</pqid></control><display><type>article</type><title>Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Yano, Kiichiro ; Gale, Daniel ; Massberg, Steffen ; Cheruvu, Pavan K. ; Monahan-Earley, Rita ; Morgan, Ellen S. ; Haig, David ; von Andrian, Ulrich H. ; Dvorak, Ann M. ; Aird, William C.</creator><creatorcontrib>Yano, Kiichiro ; Gale, Daniel ; Massberg, Steffen ; Cheruvu, Pavan K. ; Monahan-Earley, Rita ; Morgan, Ellen S. ; Haig, David ; von Andrian, Ulrich H. ; Dvorak, Ann M. ; Aird, William C.</creatorcontrib><description>Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have already been present in this ancestral vertebrate. The goal of this study was to determine whether the hagfish endothelium displays phenotypic heterogeneity. Electron microscopy of the aorta, dermis, heart, and liver revealed ultrastructural heterogeneity of the endothelium. Immunofluorescent studies demonstrated marked differences in lectin binding between vascular beds. Intravital microscopy of the dermis revealed histamine-induced adhesion of leukocytes in capillaries and postcapillary venules, but no such adhesion in arterioles. Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2006-05-026401</identifier><identifier>PMID: 16990601</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Animals ; Aorta - ultrastructure ; Biological and medical sciences ; Biological Evolution ; Blood vessels and receptors ; Capillaries - cytology ; Cell Adhesion ; Dermis - blood supply ; Dermis - ultrastructure ; Endothelium - ultrastructure ; Fundamental and applied biological sciences. Psychology ; Hagfishes - physiology ; Heart - anatomy & histology ; Lectins ; Leukocytes - cytology ; Liver - ultrastructure ; Phenotype ; Staining and Labeling ; Venules - cytology ; Vertebrates: cardiovascular system</subject><ispartof>Blood, 2007-01, Vol.109 (2), p.613-615</ispartof><rights>2007 American Society of Hematology</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-a7e76925ed5df8433b6ba78540c2b450a343885355404dc1ea3e89b9d27042693</citedby><cites>FETCH-LOGICAL-c436t-a7e76925ed5df8433b6ba78540c2b450a343885355404dc1ea3e89b9d27042693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18439353$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16990601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yano, Kiichiro</creatorcontrib><creatorcontrib>Gale, Daniel</creatorcontrib><creatorcontrib>Massberg, Steffen</creatorcontrib><creatorcontrib>Cheruvu, Pavan K.</creatorcontrib><creatorcontrib>Monahan-Earley, Rita</creatorcontrib><creatorcontrib>Morgan, Ellen S.</creatorcontrib><creatorcontrib>Haig, David</creatorcontrib><creatorcontrib>von Andrian, Ulrich H.</creatorcontrib><creatorcontrib>Dvorak, Ann M.</creatorcontrib><creatorcontrib>Aird, William C.</creatorcontrib><title>Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium</title><title>Blood</title><addtitle>Blood</addtitle><description>Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have already been present in this ancestral vertebrate. The goal of this study was to determine whether the hagfish endothelium displays phenotypic heterogeneity. Electron microscopy of the aorta, dermis, heart, and liver revealed ultrastructural heterogeneity of the endothelium. Immunofluorescent studies demonstrated marked differences in lectin binding between vascular beds. Intravital microscopy of the dermis revealed histamine-induced adhesion of leukocytes in capillaries and postcapillary venules, but no such adhesion in arterioles. Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage.</description><subject>Animals</subject><subject>Aorta - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Biological Evolution</subject><subject>Blood vessels and receptors</subject><subject>Capillaries - cytology</subject><subject>Cell Adhesion</subject><subject>Dermis - blood supply</subject><subject>Dermis - ultrastructure</subject><subject>Endothelium - ultrastructure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hagfishes - physiology</subject><subject>Heart - anatomy & histology</subject><subject>Lectins</subject><subject>Leukocytes - cytology</subject><subject>Liver - ultrastructure</subject><subject>Phenotype</subject><subject>Staining and Labeling</subject><subject>Venules - cytology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaTZp_0EourQ3p6NP25dCCWkSCLSU5ixkaZxV8UpbSV7Yfx9vdiG3ngZmnneYeQi5ZHDFWMe_DlNKvuEAugHVANcS2BuyYop3DQCHt2QFh6HsW3ZGzkv5C8Ck4Oo9OWO670EDW5Hfv9YYU91vg6NrrJjTE0YMdU9DoTZS3KVpriFFm8O0py7FgnmHno5o65yRppHWNVKMPi11CvPmA3k32qngx1O9II8_bv5c3zUPP2_vr78_NE4KXRvbYqt7rtArP3ZSiEEPtu2UBMcHqcAKKbpOCbV0pHcMrcCuH3rPW5Bc9-KCfDnu3eb0b8ZSzSYUh9NkI6a5GN1JxrSCBZRH0OVUSsbRbHPY2Lw3DMzBpXlxaQ4uDShzdLnEPp32z8MG_WvoJG8BPp8AW5ydxmyjC-WVW57qhRIL9-3I4WJjFzCb4gJGhz5kdNX4FP5_yTMTj5K4</recordid><startdate>20070115</startdate><enddate>20070115</enddate><creator>Yano, Kiichiro</creator><creator>Gale, Daniel</creator><creator>Massberg, Steffen</creator><creator>Cheruvu, Pavan K.</creator><creator>Monahan-Earley, Rita</creator><creator>Morgan, Ellen S.</creator><creator>Haig, David</creator><creator>von Andrian, Ulrich H.</creator><creator>Dvorak, Ann M.</creator><creator>Aird, William C.</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070115</creationdate><title>Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium</title><author>Yano, Kiichiro ; Gale, Daniel ; Massberg, Steffen ; Cheruvu, Pavan K. ; Monahan-Earley, Rita ; Morgan, Ellen S. ; Haig, David ; von Andrian, Ulrich H. ; Dvorak, Ann M. ; Aird, William C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-a7e76925ed5df8433b6ba78540c2b450a343885355404dc1ea3e89b9d27042693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Aorta - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Biological Evolution</topic><topic>Blood vessels and receptors</topic><topic>Capillaries - cytology</topic><topic>Cell Adhesion</topic><topic>Dermis - blood supply</topic><topic>Dermis - ultrastructure</topic><topic>Endothelium - ultrastructure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hagfishes - physiology</topic><topic>Heart - anatomy & histology</topic><topic>Lectins</topic><topic>Leukocytes - cytology</topic><topic>Liver - ultrastructure</topic><topic>Phenotype</topic><topic>Staining and Labeling</topic><topic>Venules - cytology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yano, Kiichiro</creatorcontrib><creatorcontrib>Gale, Daniel</creatorcontrib><creatorcontrib>Massberg, Steffen</creatorcontrib><creatorcontrib>Cheruvu, Pavan K.</creatorcontrib><creatorcontrib>Monahan-Earley, Rita</creatorcontrib><creatorcontrib>Morgan, Ellen S.</creatorcontrib><creatorcontrib>Haig, David</creatorcontrib><creatorcontrib>von Andrian, Ulrich H.</creatorcontrib><creatorcontrib>Dvorak, Ann M.</creatorcontrib><creatorcontrib>Aird, William C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yano, Kiichiro</au><au>Gale, Daniel</au><au>Massberg, Steffen</au><au>Cheruvu, Pavan K.</au><au>Monahan-Earley, Rita</au><au>Morgan, Ellen S.</au><au>Haig, David</au><au>von Andrian, Ulrich H.</au><au>Dvorak, Ann M.</au><au>Aird, William C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2007-01-15</date><risdate>2007</risdate><volume>109</volume><issue>2</issue><spage>613</spage><epage>615</epage><pages>613-615</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Mammalian endothelial cells (ECs) display marked phenotypic heterogeneity. Little is known about the evolutionary mechanisms underlying EC heterogeneity. The last common ancestor of hagfish and gnathostomes was also the last common ancestor of all extant vertebrates, which lived some time more than 500 million years ago. Features of ECs that are shared between hagfish and gnathostomes can be inferred to have already been present in this ancestral vertebrate. The goal of this study was to determine whether the hagfish endothelium displays phenotypic heterogeneity. Electron microscopy of the aorta, dermis, heart, and liver revealed ultrastructural heterogeneity of the endothelium. Immunofluorescent studies demonstrated marked differences in lectin binding between vascular beds. Intravital microscopy of the dermis revealed histamine-induced adhesion of leukocytes in capillaries and postcapillary venules, but no such adhesion in arterioles. Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>16990601</pmid><doi>10.1182/blood-2006-05-026401</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-4971 |
| ispartof | Blood, 2007-01, Vol.109 (2), p.613-615 |
| issn | 0006-4971 1528-0020 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68411650 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Aorta - ultrastructure Biological and medical sciences Biological Evolution Blood vessels and receptors Capillaries - cytology Cell Adhesion Dermis - blood supply Dermis - ultrastructure Endothelium - ultrastructure Fundamental and applied biological sciences. Psychology Hagfishes - physiology Heart - anatomy & histology Lectins Leukocytes - cytology Liver - ultrastructure Phenotype Staining and Labeling Venules - cytology Vertebrates: cardiovascular system |
| title | Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T12%3A21%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phenotypic%20heterogeneity%20is%20an%20evolutionarily%20conserved%20feature%20of%20the%20endothelium&rft.jtitle=Blood&rft.au=Yano,%20Kiichiro&rft.date=2007-01-15&rft.volume=109&rft.issue=2&rft.spage=613&rft.epage=615&rft.pages=613-615&rft.issn=0006-4971&rft.eissn=1528-0020&rft_id=info:doi/10.1182/blood-2006-05-026401&rft_dat=%3Cproquest_cross%3E68411650%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68411650&rft_id=info:pmid/16990601&rft_els_id=S0006497120520703&rfr_iscdi=true |