Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption

Abstract Bone has the capacity to alter its mass and structure to its mechanical environment. Osteocytes are the predominant bone cells and it is generally accepted that the osteocytes are the professional mechanosensors of bone. A strain-derived fluid flow through the lacuno-canalicular porosity se...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2007-11, Vol.41 (5), p.745-751
Hauptverfasser:	Tan, S. Djien, de Vries, Teun J, Kuijpers-Jagtman, Anne Marie, Semeins, Cornelis M, Everts, Vincent, Klein-Nulend, Jenneke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Bone Resorption Chickens Culture Media, Conditioned Fluid flow Fundamental and applied biological sciences. Psychology In vitro Mechanical loading NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide - biosynthesis Orthopedics Osteoblast Osteoclast Osteoclast activity Osteoclast formation Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteocyte Osteocytes - cytology Osteocytes - metabolism S-Nitroso-N-Acetylpenicillamine - pharmacology Skeleton and joints Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: osteoarticular system, musculoskeletal system
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