Cyclosporin A Suspends Transplantation Reactions in the Marine Sponge Microciona prolifera

Sponges are the simplest extant animals but nevertheless possess self-nonself recognition that rivals the specificity of the vertebrate MHC. We have used dissociated cell assays and grafting techniques to study tissue acceptance and rejection in the marine sponge Microciona prolifera. Our data show...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-11, Vol.179 (9), p.5927-5935
Hauptverfasser:	Sabella, Clarissa, Faszewski, Ellen, Himic, Lisa, Colpitts, Katherine M, Kaltenbach, Jane, Burger, Max M, Fernandez-Busquets, Xavier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biomarkers Cell Adhesion Molecules - metabolism Cyclosporine - pharmacology Graft Rejection - immunology Immunohistochemistry Marine Metazoa Microciona prolifera Microscopy, Electron, Transmission Porifera - cytology Porifera - drug effects Porifera - immunology Porifera - ultrastructure Time Factors Transplantation, Homologous - immunology
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