Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?
BACKGROUND: Minor histocompatibility antigens have been poorly defined. Whether Duffy (FY) and Kidd (JK), polymorphic and immunogenic blood group antigens, widely distributed in human organs, expressed and functional in the kidney, could function as minor histocompatibility antigens and be implicate...
Gespeichert in:
| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2007-01, Vol.47 (1), p.28-40 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 40 |
|---|---|
| container_issue | 1 |
| container_start_page | 28 |
| container_title | Transfusion (Philadelphia, Pa.) |
| container_volume | 47 |
| creator | Lerut, Evelyne Van Damme, Boudewijn Noizat-Pirenne, France Emonds, Marie-Paule Rouger, Philippe Vanrenterghem, Yves Pirenne, Jacques Ansart-Pirenne, Hélène |
| description | BACKGROUND: Minor histocompatibility antigens have been poorly defined. Whether Duffy (FY) and Kidd (JK), polymorphic and immunogenic blood group antigens, widely distributed in human organs, expressed and functional in the kidney, could function as minor histocompatibility antigens and be implicated in renal allograft rejection was questioned.
STUDY DESIGN AND METHODS: A retrospective, homogeneous, single‐center cohort of 370 renal transplants was analyzed. In all donor/recipient pairs, FY and JK polymorphisms were identified by real‐time polymerase chain reaction. In all donor/recipient pairs the matching (m) or mismatching (mm) status was defined for both systems. All biopsies were reviewed, and historical screening results for FY and JK alloantibodies and graft survival were retrospectively analyzed.
RESULTS: Although graft survival was not different between the groups, it was observed that FY mm grafts had significantly more chronic lesions compared to FY m grafts. HLA‐DR11 was more frequent in both recipients (p = 0.0081) and donors (p = 0.0104) of FY mm couples without chronic allograft nephropathy, suggesting a protective effect for this molecule. JK mm grafts had more interstitial inflammation than JK m grafts (p = 0.0369).
CONCLUSION: This renal model unmasks for the first time the role of FY and—to a lesser extent—JK antigens as minor histocompatibility antigens and suggests their potential role for other clinical transplant settings. |
| doi_str_mv | 10.1111/j.1537-2995.2007.01060.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68410384</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68410384</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5020-a88cdb1b5b745fc9dc858ee3586962325775618fcdecd15b85cf4b1a2989e3423</originalsourceid><addsrcrecordid>eNqNkU-PEyEYh4nRuLXrVzBc9DYjf4aB8aAxu7a6u3ETs0ZvhAGmUpmhwszafnvptule5cILPO8P8gAAxKjEebxdl5hRXpCmYSVBiJcIoxqV2ydgdjp4CmYIVbjAmJIz8CKlNUKINAg_B2eYE8QJ4TPQX05dt4NqMPDaGQNbH4KBqximTd4c3coO6R3s3RAi_OXSGHToN2p0rfNu3J0Q6Ib74O-tyQWMdlAeKu_DKqpuzOu11aMLw4dz8KxTPtmXx3kOvi8-3V18Lm5ul18uPt4UmiGCCiWENi1uWcsr1unGaMGEtZSJuqkJJYxzVmPRaWO1wawVTHdVixVpRGNpRegcvDnkbmL4M9k0yt4lbb1Xgw1TkrWoMKKiyqA4gDqGlKLt5Ca6XsWdxEjuVcu13BuVe6Nyr1o-qJbb3PrqeMfU9tY8Nh7dZuD1EVBJK99FNWiXHjlR1XWdw-fg_YH767zd_fcD5N23xUOZA4pDQP4fuz0FqPhb1pxyJn98XUq2pFc_q8WlpPQfgXOqdg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68410384</pqid></control><display><type>article</type><title>Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lerut, Evelyne ; Van Damme, Boudewijn ; Noizat-Pirenne, France ; Emonds, Marie-Paule ; Rouger, Philippe ; Vanrenterghem, Yves ; Pirenne, Jacques ; Ansart-Pirenne, Hélène</creator><creatorcontrib>Lerut, Evelyne ; Van Damme, Boudewijn ; Noizat-Pirenne, France ; Emonds, Marie-Paule ; Rouger, Philippe ; Vanrenterghem, Yves ; Pirenne, Jacques ; Ansart-Pirenne, Hélène</creatorcontrib><description>BACKGROUND: Minor histocompatibility antigens have been poorly defined. Whether Duffy (FY) and Kidd (JK), polymorphic and immunogenic blood group antigens, widely distributed in human organs, expressed and functional in the kidney, could function as minor histocompatibility antigens and be implicated in renal allograft rejection was questioned.
STUDY DESIGN AND METHODS: A retrospective, homogeneous, single‐center cohort of 370 renal transplants was analyzed. In all donor/recipient pairs, FY and JK polymorphisms were identified by real‐time polymerase chain reaction. In all donor/recipient pairs the matching (m) or mismatching (mm) status was defined for both systems. All biopsies were reviewed, and historical screening results for FY and JK alloantibodies and graft survival were retrospectively analyzed.
RESULTS: Although graft survival was not different between the groups, it was observed that FY mm grafts had significantly more chronic lesions compared to FY m grafts. HLA‐DR11 was more frequent in both recipients (p = 0.0081) and donors (p = 0.0104) of FY mm couples without chronic allograft nephropathy, suggesting a protective effect for this molecule. JK mm grafts had more interstitial inflammation than JK m grafts (p = 0.0369).
CONCLUSION: This renal model unmasks for the first time the role of FY and—to a lesser extent—JK antigens as minor histocompatibility antigens and suggests their potential role for other clinical transplant settings.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2007.01060.x</identifier><identifier>PMID: 17207227</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Group Antigens - immunology ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Child ; Cohort Studies ; Duffy Blood-Group System - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Gene Frequency ; Graft Rejection - immunology ; Graft Survival ; Histocompatibility ; HLA Antigens - genetics ; HLA-DR Antigens - blood ; HLA-DR Serological Subtypes ; Humans ; Immunohematology ; Isoantibodies - blood ; Kidd Blood-Group System - immunology ; Kidney Diseases - etiology ; Kidney Transplantation - adverse effects ; Kidney Transplantation - immunology ; Male ; Medical sciences ; Middle Aged ; Minor Histocompatibility Antigens - immunology ; Red blood cell immunology ; Retrospective Studies ; Tissue Donors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><ispartof>Transfusion (Philadelphia, Pa.), 2007-01, Vol.47 (1), p.28-40</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5020-a88cdb1b5b745fc9dc858ee3586962325775618fcdecd15b85cf4b1a2989e3423</citedby><cites>FETCH-LOGICAL-c5020-a88cdb1b5b745fc9dc858ee3586962325775618fcdecd15b85cf4b1a2989e3423</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2007.01060.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2007.01060.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18466615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17207227$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lerut, Evelyne</creatorcontrib><creatorcontrib>Van Damme, Boudewijn</creatorcontrib><creatorcontrib>Noizat-Pirenne, France</creatorcontrib><creatorcontrib>Emonds, Marie-Paule</creatorcontrib><creatorcontrib>Rouger, Philippe</creatorcontrib><creatorcontrib>Vanrenterghem, Yves</creatorcontrib><creatorcontrib>Pirenne, Jacques</creatorcontrib><creatorcontrib>Ansart-Pirenne, Hélène</creatorcontrib><title>Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Minor histocompatibility antigens have been poorly defined. Whether Duffy (FY) and Kidd (JK), polymorphic and immunogenic blood group antigens, widely distributed in human organs, expressed and functional in the kidney, could function as minor histocompatibility antigens and be implicated in renal allograft rejection was questioned.
STUDY DESIGN AND METHODS: A retrospective, homogeneous, single‐center cohort of 370 renal transplants was analyzed. In all donor/recipient pairs, FY and JK polymorphisms were identified by real‐time polymerase chain reaction. In all donor/recipient pairs the matching (m) or mismatching (mm) status was defined for both systems. All biopsies were reviewed, and historical screening results for FY and JK alloantibodies and graft survival were retrospectively analyzed.
RESULTS: Although graft survival was not different between the groups, it was observed that FY mm grafts had significantly more chronic lesions compared to FY m grafts. HLA‐DR11 was more frequent in both recipients (p = 0.0081) and donors (p = 0.0104) of FY mm couples without chronic allograft nephropathy, suggesting a protective effect for this molecule. JK mm grafts had more interstitial inflammation than JK m grafts (p = 0.0369).
CONCLUSION: This renal model unmasks for the first time the role of FY and—to a lesser extent—JK antigens as minor histocompatibility antigens and suggests their potential role for other clinical transplant settings.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Group Antigens - immunology</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Child</subject><subject>Cohort Studies</subject><subject>Duffy Blood-Group System - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Gene Frequency</subject><subject>Graft Rejection - immunology</subject><subject>Graft Survival</subject><subject>Histocompatibility</subject><subject>HLA Antigens - genetics</subject><subject>HLA-DR Antigens - blood</subject><subject>HLA-DR Serological Subtypes</subject><subject>Humans</subject><subject>Immunohematology</subject><subject>Isoantibodies - blood</subject><subject>Kidd Blood-Group System - immunology</subject><subject>Kidney Diseases - etiology</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Kidney Transplantation - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Minor Histocompatibility Antigens - immunology</subject><subject>Red blood cell immunology</subject><subject>Retrospective Studies</subject><subject>Tissue Donors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><subject>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-PEyEYh4nRuLXrVzBc9DYjf4aB8aAxu7a6u3ETs0ZvhAGmUpmhwszafnvptule5cILPO8P8gAAxKjEebxdl5hRXpCmYSVBiJcIoxqV2ydgdjp4CmYIVbjAmJIz8CKlNUKINAg_B2eYE8QJ4TPQX05dt4NqMPDaGQNbH4KBqximTd4c3coO6R3s3RAi_OXSGHToN2p0rfNu3J0Q6Ib74O-tyQWMdlAeKu_DKqpuzOu11aMLw4dz8KxTPtmXx3kOvi8-3V18Lm5ul18uPt4UmiGCCiWENi1uWcsr1unGaMGEtZSJuqkJJYxzVmPRaWO1wawVTHdVixVpRGNpRegcvDnkbmL4M9k0yt4lbb1Xgw1TkrWoMKKiyqA4gDqGlKLt5Ca6XsWdxEjuVcu13BuVe6Nyr1o-qJbb3PrqeMfU9tY8Nh7dZuD1EVBJK99FNWiXHjlR1XWdw-fg_YH767zd_fcD5N23xUOZA4pDQP4fuz0FqPhb1pxyJn98XUq2pFc_q8WlpPQfgXOqdg</recordid><startdate>200701</startdate><enddate>200701</enddate><creator>Lerut, Evelyne</creator><creator>Van Damme, Boudewijn</creator><creator>Noizat-Pirenne, France</creator><creator>Emonds, Marie-Paule</creator><creator>Rouger, Philippe</creator><creator>Vanrenterghem, Yves</creator><creator>Pirenne, Jacques</creator><creator>Ansart-Pirenne, Hélène</creator><general>Blackwell Publishing Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200701</creationdate><title>Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?</title><author>Lerut, Evelyne ; Van Damme, Boudewijn ; Noizat-Pirenne, France ; Emonds, Marie-Paule ; Rouger, Philippe ; Vanrenterghem, Yves ; Pirenne, Jacques ; Ansart-Pirenne, Hélène</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5020-a88cdb1b5b745fc9dc858ee3586962325775618fcdecd15b85cf4b1a2989e3423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Group Antigens - immunology</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Child</topic><topic>Cohort Studies</topic><topic>Duffy Blood-Group System - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Gene Frequency</topic><topic>Graft Rejection - immunology</topic><topic>Graft Survival</topic><topic>Histocompatibility</topic><topic>HLA Antigens - genetics</topic><topic>HLA-DR Antigens - blood</topic><topic>HLA-DR Serological Subtypes</topic><topic>Humans</topic><topic>Immunohematology</topic><topic>Isoantibodies - blood</topic><topic>Kidd Blood-Group System - immunology</topic><topic>Kidney Diseases - etiology</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Kidney Transplantation - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Minor Histocompatibility Antigens - immunology</topic><topic>Red blood cell immunology</topic><topic>Retrospective Studies</topic><topic>Tissue Donors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><topic>Vertebrates: blood, hematopoietic organs, reticuloendothelial system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lerut, Evelyne</creatorcontrib><creatorcontrib>Van Damme, Boudewijn</creatorcontrib><creatorcontrib>Noizat-Pirenne, France</creatorcontrib><creatorcontrib>Emonds, Marie-Paule</creatorcontrib><creatorcontrib>Rouger, Philippe</creatorcontrib><creatorcontrib>Vanrenterghem, Yves</creatorcontrib><creatorcontrib>Pirenne, Jacques</creatorcontrib><creatorcontrib>Ansart-Pirenne, Hélène</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lerut, Evelyne</au><au>Van Damme, Boudewijn</au><au>Noizat-Pirenne, France</au><au>Emonds, Marie-Paule</au><au>Rouger, Philippe</au><au>Vanrenterghem, Yves</au><au>Pirenne, Jacques</au><au>Ansart-Pirenne, Hélène</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection?</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2007-01</date><risdate>2007</risdate><volume>47</volume><issue>1</issue><spage>28</spage><epage>40</epage><pages>28-40</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Minor histocompatibility antigens have been poorly defined. Whether Duffy (FY) and Kidd (JK), polymorphic and immunogenic blood group antigens, widely distributed in human organs, expressed and functional in the kidney, could function as minor histocompatibility antigens and be implicated in renal allograft rejection was questioned.
STUDY DESIGN AND METHODS: A retrospective, homogeneous, single‐center cohort of 370 renal transplants was analyzed. In all donor/recipient pairs, FY and JK polymorphisms were identified by real‐time polymerase chain reaction. In all donor/recipient pairs the matching (m) or mismatching (mm) status was defined for both systems. All biopsies were reviewed, and historical screening results for FY and JK alloantibodies and graft survival were retrospectively analyzed.
RESULTS: Although graft survival was not different between the groups, it was observed that FY mm grafts had significantly more chronic lesions compared to FY m grafts. HLA‐DR11 was more frequent in both recipients (p = 0.0081) and donors (p = 0.0104) of FY mm couples without chronic allograft nephropathy, suggesting a protective effect for this molecule. JK mm grafts had more interstitial inflammation than JK m grafts (p = 0.0369).
CONCLUSION: This renal model unmasks for the first time the role of FY and—to a lesser extent—JK antigens as minor histocompatibility antigens and suggests their potential role for other clinical transplant settings.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17207227</pmid><doi>10.1111/j.1537-2995.2007.01060.x</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1132 |
| ispartof | Transfusion (Philadelphia, Pa.), 2007-01, Vol.47 (1), p.28-40 |
| issn | 0041-1132 1537-2995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68410384 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Group Antigens - immunology Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Child Cohort Studies Duffy Blood-Group System - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Frequency Graft Rejection - immunology Graft Survival Histocompatibility HLA Antigens - genetics HLA-DR Antigens - blood HLA-DR Serological Subtypes Humans Immunohematology Isoantibodies - blood Kidd Blood-Group System - immunology Kidney Diseases - etiology Kidney Transplantation - adverse effects Kidney Transplantation - immunology Male Medical sciences Middle Aged Minor Histocompatibility Antigens - immunology Red blood cell immunology Retrospective Studies Tissue Donors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Vertebrates: blood, hematopoietic organs, reticuloendothelial system |
| title | Duffy and Kidd blood group antigens: minor histocompatibility antigens involved in renal allograft rejection? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T15%3A16%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Duffy%20and%20Kidd%20blood%20group%20antigens:%20minor%20histocompatibility%20antigens%20involved%20in%20renal%20allograft%20rejection?&rft.jtitle=Transfusion%20(Philadelphia,%20Pa.)&rft.au=Lerut,%20Evelyne&rft.date=2007-01&rft.volume=47&rft.issue=1&rft.spage=28&rft.epage=40&rft.pages=28-40&rft.issn=0041-1132&rft.eissn=1537-2995&rft.coden=TRANAT&rft_id=info:doi/10.1111/j.1537-2995.2007.01060.x&rft_dat=%3Cproquest_cross%3E68410384%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68410384&rft_id=info:pmid/17207227&rfr_iscdi=true |