High-Affinity TCRs Generated by Phage Display Provide CD4+ T Cells with the Ability to Recognize and Kill Tumor Cell Lines

We examined the activity of human T cells engineered to express variants of a single TCR (1G4) specific for the cancer/testis Ag NY-ESO-1, generated by bacteriophage display with a wide range of affinities (from 4 microM to 26 pM). CD8(+) T cells expressing intermediate- and high-affinity 1G4 TCR va...

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Veröffentlicht in:	The Journal of immunology (1950) 2007-11, Vol.179 (9), p.5845-5854
Hauptverfasser:	Zhao, Yangbing, Bennett, Alan D, Zheng, Zhili, Wang, Qiong J, Robbins, Paul F, Yu, Lawrence Y. L, Li, Yi, Molloy, Peter E, Dunn, Steven M, Jakobsen, Bent K, Rosenberg, Steven A, Morgan, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigen-Presenting Cells - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - immunology Cell Survival Cells, Cultured Cross Reactions - immunology Histocompatibility Antigens - immunology Humans Lymphocyte Activation - immunology Molecular Sequence Data Neoplasms - immunology Neoplasms - metabolism Neoplasms - pathology Peptide Library Receptors, Antigen, T-Cell - chemistry Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Sensitivity and Specificity
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