Chicken antibody against a restrictive epitope of prion protein distinguishes normal and abnormal prion proteins

Recently, we reported the application of a recombinant chicken IgY monoclonal antibody, Ab3–15, against mammalian prion protein (PrP), for the diagnosis of bovine spongiform encephalopathy in cattle. In this study, we have characterized a soluble, single-chain variable fragment (scFv) form of this a...

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Veröffentlicht in:	Biologicals 2007-10, Vol.35 (4), p.303-308
Hauptverfasser:	Miyamoto, Kazuyoshi, Kimura, Sota, Nakamura, Naoto, Yokoyama, Takashi, Horiuchi, Hiroyuki, Furusawa, Shuichi, Matsuda, Haruo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Specificity Blotting, Western Cattle Chicken monoclonal antibody Chickens Enzyme-Linked Immunosorbent Assay Epitopes - immunology Mice Prion Diseases - diagnosis Prion Diseases - immunology Prion protein Prions - immunology PrP-specific antibody PrPC Proteins - immunology PrPSc Proteins - immunology scFv antibody Scrapie - diagnosis Scrapie - immunology
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