Reconstruction of orbital wall defects with calcium phosphate cement: clinical and histological findings in a sheep model
Abstract The aim of this pilot study was to investigate the potential of calcium phosphate cement in the treatment of orbital wall defect fractures in an adult sheep model, and to compare this alloplastic material to autologous calvaria split-bone grafts. Clinical, volumetric and histological examin...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 2007-01, Vol.36 (1), p.54-61 |
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| container_title | International journal of oral and maxillofacial surgery |
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| creator | Šiniković, B Kramer, F.-J Swennen, G Lübbers, H.-T Dempf, R |
| description | Abstract The aim of this pilot study was to investigate the potential of calcium phosphate cement in the treatment of orbital wall defect fractures in an adult sheep model, and to compare this alloplastic material to autologous calvaria split-bone grafts. Clinical, volumetric and histological examinations were carried out of both reconstruction materials. The use of cement made intraoperative corrections easier to perform, and increased the precision of reconstruction of the orbital volume. This material also proved to be osseoconductive. The two materials were used successfully in combination. Regions of most intensive remodelling were the anterior orbital floor and the adjacent orbital rim. The preliminary results of this study demonstrate the potential of calcium phosphate cement as a useful biomaterial in the reconstruction of the anterior orbital region. Further animal and clinical trials are necessary to investigate its ability as a carrier for mediators where bone healing requires influence or support. |
| doi_str_mv | 10.1016/j.ijom.2006.07.014 |
| format | Article |
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Clinical, volumetric and histological examinations were carried out of both reconstruction materials. The use of cement made intraoperative corrections easier to perform, and increased the precision of reconstruction of the orbital volume. This material also proved to be osseoconductive. The two materials were used successfully in combination. Regions of most intensive remodelling were the anterior orbital floor and the adjacent orbital rim. The preliminary results of this study demonstrate the potential of calcium phosphate cement as a useful biomaterial in the reconstruction of the anterior orbital region. Further animal and clinical trials are necessary to investigate its ability as a carrier for mediators where bone healing requires influence or support.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/j.ijom.2006.07.014</identifier><identifier>PMID: 16965899</identifier><identifier>CODEN: IJOSE9</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Animals ; Biocompatible Materials - pharmacology ; Biological and medical sciences ; Bone Cements - chemistry ; Bone Cements - pharmacology ; Bone Cements - therapeutic use ; Bone Regeneration - drug effects ; bone replacement ; Bone Transplantation ; calcium phosphate cement ; Calcium Phosphates - pharmacology ; defect fracture ; Dentistry ; Female ; Injuries of the limb. Injuries of the spine ; Medical sciences ; Models, Animal ; Orbit - surgery ; orbita ; Orbital Fractures - surgery ; osseoconduction ; Otorhinolaryngology. Stomatology ; Pilot Projects ; Reconstructive Surgical Procedures - methods ; Sheep ; Surgery ; Surgery, Computer-Assisted ; Traumas. 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Clinical, volumetric and histological examinations were carried out of both reconstruction materials. The use of cement made intraoperative corrections easier to perform, and increased the precision of reconstruction of the orbital volume. This material also proved to be osseoconductive. The two materials were used successfully in combination. Regions of most intensive remodelling were the anterior orbital floor and the adjacent orbital rim. The preliminary results of this study demonstrate the potential of calcium phosphate cement as a useful biomaterial in the reconstruction of the anterior orbital region. Further animal and clinical trials are necessary to investigate its ability as a carrier for mediators where bone healing requires influence or support.</description><subject>Animals</subject><subject>Biocompatible Materials - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bone Cements - chemistry</subject><subject>Bone Cements - pharmacology</subject><subject>Bone Cements - therapeutic use</subject><subject>Bone Regeneration - drug effects</subject><subject>bone replacement</subject><subject>Bone Transplantation</subject><subject>calcium phosphate cement</subject><subject>Calcium Phosphates - pharmacology</subject><subject>defect fracture</subject><subject>Dentistry</subject><subject>Female</subject><subject>Injuries of the limb. Injuries of the spine</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Orbit - surgery</subject><subject>orbita</subject><subject>Orbital Fractures - surgery</subject><subject>osseoconduction</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Pilot Projects</subject><subject>Reconstructive Surgical Procedures - methods</subject><subject>Sheep</subject><subject>Surgery</subject><subject>Surgery, Computer-Assisted</subject><subject>Traumas. 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Injuries of the spine</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Orbit - surgery</topic><topic>orbita</topic><topic>Orbital Fractures - surgery</topic><topic>osseoconduction</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Pilot Projects</topic><topic>Reconstructive Surgical Procedures - methods</topic><topic>Sheep</topic><topic>Surgery</topic><topic>Surgery, Computer-Assisted</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Šiniković, B</creatorcontrib><creatorcontrib>Kramer, F.-J</creatorcontrib><creatorcontrib>Swennen, G</creatorcontrib><creatorcontrib>Lübbers, H.-T</creatorcontrib><creatorcontrib>Dempf, R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Šiniković, B</au><au>Kramer, F.-J</au><au>Swennen, G</au><au>Lübbers, H.-T</au><au>Dempf, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reconstruction of orbital wall defects with calcium phosphate cement: clinical and histological findings in a sheep model</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>36</volume><issue>1</issue><spage>54</spage><epage>61</epage><pages>54-61</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><coden>IJOSE9</coden><abstract>Abstract The aim of this pilot study was to investigate the potential of calcium phosphate cement in the treatment of orbital wall defect fractures in an adult sheep model, and to compare this alloplastic material to autologous calvaria split-bone grafts. Clinical, volumetric and histological examinations were carried out of both reconstruction materials. The use of cement made intraoperative corrections easier to perform, and increased the precision of reconstruction of the orbital volume. This material also proved to be osseoconductive. The two materials were used successfully in combination. Regions of most intensive remodelling were the anterior orbital floor and the adjacent orbital rim. The preliminary results of this study demonstrate the potential of calcium phosphate cement as a useful biomaterial in the reconstruction of the anterior orbital region. Further animal and clinical trials are necessary to investigate its ability as a carrier for mediators where bone healing requires influence or support.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>16965899</pmid><doi>10.1016/j.ijom.2006.07.014</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biocompatible Materials - pharmacology Biological and medical sciences Bone Cements - chemistry Bone Cements - pharmacology Bone Cements - therapeutic use Bone Regeneration - drug effects bone replacement Bone Transplantation calcium phosphate cement Calcium Phosphates - pharmacology defect fracture Dentistry Female Injuries of the limb. Injuries of the spine Medical sciences Models, Animal Orbit - surgery orbita Orbital Fractures - surgery osseoconduction Otorhinolaryngology. Stomatology Pilot Projects Reconstructive Surgical Procedures - methods Sheep Surgery Surgery, Computer-Assisted Traumas. Diseases due to physical agents |
| title | Reconstruction of orbital wall defects with calcium phosphate cement: clinical and histological findings in a sheep model |
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