quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN)

The P. aeruginosa quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) interacts not only with bacteria, but also with mammalian cells, among others with those of the immune defence system. We focussed on the possible interaction of 3OC12-HSL with human polymorphonuclear neutroph...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2007-01, Vol.387 (2), p.481-487
Hauptverfasser:	Wagner, Christof, Zimmermann, Sabine, Brenner-Weiss, Gerald, Hug, Friederike, Prior, Birgit, Obst, Ursula, Hänsch, Gertrud Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - immunology 4-Butyrolactone - pharmacology Bacteria - chemistry Bacteria - immunology Bacteria - pathogenicity Biofilms Cell Communication - immunology Cells, Cultured Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - immunology Functional activity Homoserine - analogs & derivatives Homoserine - immunology Homoserine - pharmacology Homoserine lactone Host defence Humans Immunity - drug effects Neutrophil Activation - immunology Phagocytosis PMN Pseudomonas aeruginosa - immunology Pseudomonas aeruginosa - pathogenicity Quorum Sensing Receptors, Immunologic - genetics Up-Regulation - genetics Up-Regulation - immunology
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