quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN)
The P. aeruginosa quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) interacts not only with bacteria, but also with mammalian cells, among others with those of the immune defence system. We focussed on the possible interaction of 3OC12-HSL with human polymorphonuclear neutroph...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2007-01, Vol.387 (2), p.481-487 |
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| creator | Wagner, Christof Zimmermann, Sabine Brenner-Weiss, Gerald Hug, Friederike Prior, Birgit Obst, Ursula Hänsch, Gertrud Maria |
| description | The P. aeruginosa quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) interacts not only with bacteria, but also with mammalian cells, among others with those of the immune defence system. We focussed on the possible interaction of 3OC12-HSL with human polymorphonuclear neutrophils (PMN), because these cells are the first to enter an infected site. We found that 3OC12-HSL attracts PMN, and up-regulates expression of receptors known to be involved in host defence, including the adhesion proteins CD11b/CD18 and the immunoglobulin receptors CD16 and CD64. Furthermore, the uptake of bacteria (phagocytosis), which is crucial for an efficient defence against infection, was enhanced. Thus, recognising and responding to 3OC12-HSL not only attracts the PMN to the site of a developing biofilm, but also reinforces their defence mechanisms, and hence could be a means to control the infection in an early stage and to prevent biofilm formation. |
| doi_str_mv | 10.1007/s00216-006-0698-5 |
| format | Article |
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We focussed on the possible interaction of 3OC12-HSL with human polymorphonuclear neutrophils (PMN), because these cells are the first to enter an infected site. We found that 3OC12-HSL attracts PMN, and up-regulates expression of receptors known to be involved in host defence, including the adhesion proteins CD11b/CD18 and the immunoglobulin receptors CD16 and CD64. Furthermore, the uptake of bacteria (phagocytosis), which is crucial for an efficient defence against infection, was enhanced. Thus, recognising and responding to 3OC12-HSL not only attracts the PMN to the site of a developing biofilm, but also reinforces their defence mechanisms, and hence could be a means to control the infection in an early stage and to prevent biofilm formation.</description><subject>4-Butyrolactone - analogs & derivatives</subject><subject>4-Butyrolactone - immunology</subject><subject>4-Butyrolactone - pharmacology</subject><subject>Bacteria - chemistry</subject><subject>Bacteria - immunology</subject><subject>Bacteria - pathogenicity</subject><subject>Biofilms</subject><subject>Cell Communication - immunology</subject><subject>Cells, Cultured</subject><subject>Chemotaxis, Leukocyte - drug effects</subject><subject>Chemotaxis, Leukocyte - immunology</subject><subject>Functional activity</subject><subject>Homoserine - analogs & derivatives</subject><subject>Homoserine - immunology</subject><subject>Homoserine - pharmacology</subject><subject>Homoserine lactone</subject><subject>Host defence</subject><subject>Humans</subject><subject>Immunity - drug effects</subject><subject>Neutrophil Activation - immunology</subject><subject>Phagocytosis</subject><subject>PMN</subject><subject>Pseudomonas aeruginosa - immunology</subject><subject>Pseudomonas aeruginosa - pathogenicity</subject><subject>Quorum Sensing</subject><subject>Receptors, Immunologic - genetics</subject><subject>Up-Regulation - genetics</subject><subject>Up-Regulation - immunology</subject><issn>1618-2642</issn><issn>1618-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEoqXwAFzAJ9QeDGM7dpxjtaIUaWmRSs-W40yaICdO7QSxr9KnxatdwZGDNaPR53-k-YriLYOPDKD6lAA4UxQgP1VrKp8Vp0wxTbmS8PxvX_KT4lVKPwGY1Ey9LE6YqkEJLU6Lp8c1xHWkCac0TA9kDB7d6pHcUEHD79CGFp2dws6TPowhYRwmJN66JeR6Lm43jNPru-0Fwam3k8NElh4zmxbSYod5Qpodyfzwyy77Df062onMwe_GEOc-TKvzaCOZcF1imPvBJ3L-_dvNxeviRWd9wjfHelbcX33-sbmm29svXzeXW-qELBcqmAZdWRCta6qGtxJ0zWtguqty54C5qpKoG6hVKWU-jG1Vi2XTdaq1HBpxVnw45M4xPK6YFjMOyaH3dsKwJqN0CXUJ8r8gr6WUlSozyA6giyGliJ2Z4zDauDMMzN6cOZgz2ZzZmzP78HfH8LUZsf3346gqA-8PQGeDsQ9xSOb-jgMTOa_imgvxBzqqnlg</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Wagner, Christof</creator><creator>Zimmermann, Sabine</creator><creator>Brenner-Weiss, Gerald</creator><creator>Hug, Friederike</creator><creator>Prior, Birgit</creator><creator>Obst, Ursula</creator><creator>Hänsch, Gertrud Maria</creator><general>Berlin/Heidelberg : Springer-Verlag</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN)</title><author>Wagner, Christof ; Zimmermann, Sabine ; Brenner-Weiss, Gerald ; Hug, Friederike ; Prior, Birgit ; Obst, Ursula ; Hänsch, Gertrud Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-318087a03dcb7b2d508929018f7089c01c775e8b096455650ad6de4bff6da20b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>4-Butyrolactone - analogs & derivatives</topic><topic>4-Butyrolactone - immunology</topic><topic>4-Butyrolactone - pharmacology</topic><topic>Bacteria - chemistry</topic><topic>Bacteria - immunology</topic><topic>Bacteria - pathogenicity</topic><topic>Biofilms</topic><topic>Cell Communication - immunology</topic><topic>Cells, Cultured</topic><topic>Chemotaxis, Leukocyte - drug effects</topic><topic>Chemotaxis, Leukocyte - immunology</topic><topic>Functional activity</topic><topic>Homoserine - analogs & derivatives</topic><topic>Homoserine - immunology</topic><topic>Homoserine - pharmacology</topic><topic>Homoserine lactone</topic><topic>Host defence</topic><topic>Humans</topic><topic>Immunity - drug effects</topic><topic>Neutrophil Activation - immunology</topic><topic>Phagocytosis</topic><topic>PMN</topic><topic>Pseudomonas aeruginosa - immunology</topic><topic>Pseudomonas aeruginosa - pathogenicity</topic><topic>Quorum Sensing</topic><topic>Receptors, Immunologic - genetics</topic><topic>Up-Regulation - genetics</topic><topic>Up-Regulation - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagner, Christof</creatorcontrib><creatorcontrib>Zimmermann, Sabine</creatorcontrib><creatorcontrib>Brenner-Weiss, Gerald</creatorcontrib><creatorcontrib>Hug, Friederike</creatorcontrib><creatorcontrib>Prior, Birgit</creatorcontrib><creatorcontrib>Obst, Ursula</creatorcontrib><creatorcontrib>Hänsch, Gertrud Maria</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Analytical and bioanalytical chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wagner, Christof</au><au>Zimmermann, Sabine</au><au>Brenner-Weiss, Gerald</au><au>Hug, Friederike</au><au>Prior, Birgit</au><au>Obst, Ursula</au><au>Hänsch, Gertrud Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN)</atitle><jtitle>Analytical and bioanalytical chemistry</jtitle><addtitle>Anal Bioanal Chem</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>387</volume><issue>2</issue><spage>481</spage><epage>487</epage><pages>481-487</pages><issn>1618-2642</issn><eissn>1618-2650</eissn><abstract>The P. aeruginosa quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) interacts not only with bacteria, but also with mammalian cells, among others with those of the immune defence system. We focussed on the possible interaction of 3OC12-HSL with human polymorphonuclear neutrophils (PMN), because these cells are the first to enter an infected site. We found that 3OC12-HSL attracts PMN, and up-regulates expression of receptors known to be involved in host defence, including the adhesion proteins CD11b/CD18 and the immunoglobulin receptors CD16 and CD64. Furthermore, the uptake of bacteria (phagocytosis), which is crucial for an efficient defence against infection, was enhanced. Thus, recognising and responding to 3OC12-HSL not only attracts the PMN to the site of a developing biofilm, but also reinforces their defence mechanisms, and hence could be a means to control the infection in an early stage and to prevent biofilm formation.</abstract><cop>Germany</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>16906383</pmid><doi>10.1007/s00216-006-0698-5</doi><tpages>7</tpages></addata></record> |
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| subjects | 4-Butyrolactone - analogs & derivatives 4-Butyrolactone - immunology 4-Butyrolactone - pharmacology Bacteria - chemistry Bacteria - immunology Bacteria - pathogenicity Biofilms Cell Communication - immunology Cells, Cultured Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - immunology Functional activity Homoserine - analogs & derivatives Homoserine - immunology Homoserine - pharmacology Homoserine lactone Host defence Humans Immunity - drug effects Neutrophil Activation - immunology Phagocytosis PMN Pseudomonas aeruginosa - immunology Pseudomonas aeruginosa - pathogenicity Quorum Sensing Receptors, Immunologic - genetics Up-Regulation - genetics Up-Regulation - immunology |
| title | quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN) |
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