Increased atherosclerosis following treatment with a dual PPAR agonist in the ApoE knockout mouse

Abstract Objective Recent reports have suggested that dual peroxisome proliferator-activated receptor (PPAR) α/γ agonists are associated with adverse cardiovascular events. This study aimed to investigate the actions of the non-thiazolidinedione PPARα/γ agonist, compound 3q , on plaque development i...

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Veröffentlicht in:	Atherosclerosis 2007-11, Vol.195 (1), p.17-22
Hauptverfasser:	Calkin, Anna C, Allen, Terri J, Lassila, Markus, Tikellis, Christos, Jandeleit-Dahm, Karin A, Thomas, Merlin C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein E Apolipoproteins E - genetics Atherosclerosis Atherosclerosis (general aspects, experimental research) Atherosclerosis - diagnosis Atherosclerosis - drug therapy Atherosclerosis - genetics Biological and medical sciences Blood and lymphatic vessels Blood Pressure Cardiology. Vascular system Cardiovascular Cardiovascular Diseases - genetics Cell Adhesion Diabetes Diseases of the cardiovascular system Diseases of the lymphatic vessels Gemfibrozil - pharmacology Gene Expression Profiling Glitazone Lipids - chemistry Male Medical sciences Mice Mice, Knockout Peroxisome Proliferator-Activated Receptors - agonists PPAR Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Thiazolidinediones - pharmacology
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