Activity of 7-methyljuglone derivatives against Mycobacterium tuberculosis and as subversive substrates for mycothiol disulfide reductase

The naphthoquinone 7-methyljuglone (5-hydroxy-7-methyl-1,4-naphthoquinone) has previously been isolated and identified as an active component of root extracts of Euclea natalensis which displays antitubercular activity. Herein, a series of synthetic and plant-derived naphthoquinone derivates of the...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2007-12, Vol.15 (24), p.7638-7646
Hauptverfasser:	Mahapatra, Anita, Mativandlela, Sannah P.N., Binneman, B., Fourie, P.B., Hamilton, Chris J., Meyer, J.J.M., van der Kooy, F., Houghton, Peter, Lall, Namrita
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Disulfide reductase Dose-Response Relationship, Drug Ebenaceae - chemistry Medical sciences Microbial Sensitivity Tests Molecular Structure Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Mycothiol NADH, NADPH Oxidoreductases - chemistry NADH, NADPH Oxidoreductases - metabolism Naphthoquinones Naphthoquinones - chemistry Naphthoquinones - pharmacology Pharmacology. Drug treatments Plant Roots - chemistry Subversive substrates Tuberculosis
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