Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin
Two of the classical kallikrein genes KLK3 and KLK2 on 19q13.4 are plausible candidates in prostate cancer susceptibility. They are expressed almost exclusively in prostate tissue. We have performed a comprehensive analysis of association of variants in these two genes with prostate cancer among men...
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| Veröffentlicht in: | Human genetics 2007-11, Vol.122 (3-4), p.251-259 |
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| creator | PAL, Prodipto HUIFENG XI DEKA, Ranjan GUANGYUN SUN KAUSHAL, Ritesh MEEKS, Joshua J SHAD THAXTON, C GUHA, Saurav JIN, Carol H SUAREZ, Brian K CATALONA, William J |
| description | Two of the classical kallikrein genes KLK3 and KLK2 on 19q13.4 are plausible candidates in prostate cancer susceptibility. They are expressed almost exclusively in prostate tissue. We have performed a comprehensive analysis of association of variants in these two genes with prostate cancer among men of European descent using a tagging SNP approach. Thirteen SNPs selected from the HapMap database were analyzed in a sample of 596 histologically verified prostate cancer cases and 567 ethnically matched controls. Five SNPs showed significant association at single marker level. Linkage disequilibrium (LD) analysis revealed four LD blocks. We performed a haplotype analysis within each LD block. A major haplotype in block 1 that contains the first two significantly associated SNPs was significantly underrepresented in the prostate cancer cases; a second haplotype in block 3 also showed significant frequency differences between cases and controls. Four of the studied SNPs show positive associations with serum PSA levels. A structure analysis revealed no population stratification in our samples that could have confounded the association results. These findings suggest a plausible role of kallikrein gene variants in the etiology of prostate cancer among men of European ancestry. |
| doi_str_mv | 10.1007/s00439-007-0394-3 |
| format | Article |
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They are expressed almost exclusively in prostate tissue. We have performed a comprehensive analysis of association of variants in these two genes with prostate cancer among men of European descent using a tagging SNP approach. Thirteen SNPs selected from the HapMap database were analyzed in a sample of 596 histologically verified prostate cancer cases and 567 ethnically matched controls. Five SNPs showed significant association at single marker level. Linkage disequilibrium (LD) analysis revealed four LD blocks. We performed a haplotype analysis within each LD block. A major haplotype in block 1 that contains the first two significantly associated SNPs was significantly underrepresented in the prostate cancer cases; a second haplotype in block 3 also showed significant frequency differences between cases and controls. Four of the studied SNPs show positive associations with serum PSA levels. A structure analysis revealed no population stratification in our samples that could have confounded the association results. These findings suggest a plausible role of kallikrein gene variants in the etiology of prostate cancer among men of European ancestry.</description><identifier>ISSN: 0340-6717</identifier><identifier>EISSN: 1432-1203</identifier><identifier>DOI: 10.1007/s00439-007-0394-3</identifier><identifier>PMID: 17593395</identifier><identifier>CODEN: HUGEDQ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Alleles ; Analysis ; Biological and medical sciences ; Cancer ; Case-Control Studies ; Chromosomes, Human, Pair 19 - genetics ; Classical genetics, quantitative genetics, hybrids ; Development and progression ; Disease susceptibility ; DNA, Neoplasm - genetics ; European Continental Ancestry Group - genetics ; Fundamental and applied biological sciences. Psychology ; Gene Frequency ; Genes ; Genetic aspects ; Genetics of eukaryotes. Biological and molecular evolution ; Genomes ; Gynecology. Andrology. Obstetrics ; Haplotypes ; Human ; Humans ; Kallikrein ; Linkage Disequilibrium ; Male ; Male genital diseases ; Medical sciences ; Medical screening ; Nephrology. Urinary tract diseases ; Polymorphism, Single Nucleotide ; Prostate cancer ; Prostate-specific antigen ; Prostate-Specific Antigen - blood ; Prostate-Specific Antigen - genetics ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - genetics ; Single nucleotide polymorphisms ; Tissue Kallikreins - genetics ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Urology</subject><ispartof>Human genetics, 2007-11, Vol.122 (3-4), p.251-259</ispartof><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2007 Springer</rights><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-403a0b1d5dfa12d284cf832c094c6076a6cd034fdb84c8a9c2f667e264f7493f3</citedby><cites>FETCH-LOGICAL-c449t-403a0b1d5dfa12d284cf832c094c6076a6cd034fdb84c8a9c2f667e264f7493f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19946567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17593395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PAL, Prodipto</creatorcontrib><creatorcontrib>HUIFENG XI</creatorcontrib><creatorcontrib>DEKA, Ranjan</creatorcontrib><creatorcontrib>GUANGYUN SUN</creatorcontrib><creatorcontrib>KAUSHAL, Ritesh</creatorcontrib><creatorcontrib>MEEKS, Joshua J</creatorcontrib><creatorcontrib>SHAD THAXTON, C</creatorcontrib><creatorcontrib>GUHA, Saurav</creatorcontrib><creatorcontrib>JIN, Carol H</creatorcontrib><creatorcontrib>SUAREZ, Brian K</creatorcontrib><creatorcontrib>CATALONA, William J</creatorcontrib><title>Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin</title><title>Human genetics</title><addtitle>Hum Genet</addtitle><description>Two of the classical kallikrein genes KLK3 and KLK2 on 19q13.4 are plausible candidates in prostate cancer susceptibility. They are expressed almost exclusively in prostate tissue. We have performed a comprehensive analysis of association of variants in these two genes with prostate cancer among men of European descent using a tagging SNP approach. Thirteen SNPs selected from the HapMap database were analyzed in a sample of 596 histologically verified prostate cancer cases and 567 ethnically matched controls. Five SNPs showed significant association at single marker level. Linkage disequilibrium (LD) analysis revealed four LD blocks. We performed a haplotype analysis within each LD block. A major haplotype in block 1 that contains the first two significantly associated SNPs was significantly underrepresented in the prostate cancer cases; a second haplotype in block 3 also showed significant frequency differences between cases and controls. Four of the studied SNPs show positive associations with serum PSA levels. A structure analysis revealed no population stratification in our samples that could have confounded the association results. These findings suggest a plausible role of kallikrein gene variants in the etiology of prostate cancer among men of European ancestry.</description><subject>Aged</subject><subject>Alleles</subject><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Chromosomes, Human, Pair 19 - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Development and progression</subject><subject>Disease susceptibility</subject><subject>DNA, Neoplasm - genetics</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Frequency</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genomes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Haplotypes</subject><subject>Human</subject><subject>Humans</subject><subject>Kallikrein</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Male genital diseases</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prostate cancer</subject><subject>Prostate-specific antigen</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostate-Specific Antigen - genetics</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Single nucleotide polymorphisms</subject><subject>Tissue Kallikreins - genetics</subject><subject>Tumors</subject><subject>Tumors of the urinary system</subject><subject>Urinary tract. 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Psychology</topic><topic>Gene Frequency</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genomes</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Haplotypes</topic><topic>Human</topic><topic>Humans</topic><topic>Kallikrein</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Male genital diseases</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prostate cancer</topic><topic>Prostate-specific antigen</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostate-Specific Antigen - genetics</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Single nucleotide polymorphisms</topic><topic>Tissue Kallikreins - genetics</topic><topic>Tumors</topic><topic>Tumors of the urinary system</topic><topic>Urinary tract. 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They are expressed almost exclusively in prostate tissue. We have performed a comprehensive analysis of association of variants in these two genes with prostate cancer among men of European descent using a tagging SNP approach. Thirteen SNPs selected from the HapMap database were analyzed in a sample of 596 histologically verified prostate cancer cases and 567 ethnically matched controls. Five SNPs showed significant association at single marker level. Linkage disequilibrium (LD) analysis revealed four LD blocks. We performed a haplotype analysis within each LD block. A major haplotype in block 1 that contains the first two significantly associated SNPs was significantly underrepresented in the prostate cancer cases; a second haplotype in block 3 also showed significant frequency differences between cases and controls. Four of the studied SNPs show positive associations with serum PSA levels. A structure analysis revealed no population stratification in our samples that could have confounded the association results. These findings suggest a plausible role of kallikrein gene variants in the etiology of prostate cancer among men of European ancestry.</abstract><cop>Heidelberg</cop><cop>Berlin</cop><cop>New York, NY</cop><pub>Springer</pub><pmid>17593395</pmid><doi>10.1007/s00439-007-0394-3</doi><tpages>9</tpages></addata></record> |
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| ispartof | Human genetics, 2007-11, Vol.122 (3-4), p.251-259 |
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| subjects | Aged Alleles Analysis Biological and medical sciences Cancer Case-Control Studies Chromosomes, Human, Pair 19 - genetics Classical genetics, quantitative genetics, hybrids Development and progression Disease susceptibility DNA, Neoplasm - genetics European Continental Ancestry Group - genetics Fundamental and applied biological sciences. Psychology Gene Frequency Genes Genetic aspects Genetics of eukaryotes. Biological and molecular evolution Genomes Gynecology. Andrology. Obstetrics Haplotypes Human Humans Kallikrein Linkage Disequilibrium Male Male genital diseases Medical sciences Medical screening Nephrology. Urinary tract diseases Polymorphism, Single Nucleotide Prostate cancer Prostate-specific antigen Prostate-Specific Antigen - blood Prostate-Specific Antigen - genetics Prostatic Neoplasms - blood Prostatic Neoplasms - genetics Single nucleotide polymorphisms Tissue Kallikreins - genetics Tumors Tumors of the urinary system Urinary tract. Prostate gland Urology |
| title | Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin |
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