Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats
Abstract Lactoferrin (LF) is a multifunctional protein present in secretory fluids of mammals and circulating neutrophils. Beside anti-inflammatory properties, LF was found to inhibit some autoimmune disorders. In this investigation we studied effects of oral administration of LF on experimental aut...
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| Veröffentlicht in: | Journal of neuroimmunology 2007-01, Vol.182 (1), p.160-166 |
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| creator | Zimecki, Michał Kocięba, Maja Chodaczek, Grzegorz Houszka, Marek Kruzel, Marian L |
| description | Abstract Lactoferrin (LF) is a multifunctional protein present in secretory fluids of mammals and circulating neutrophils. Beside anti-inflammatory properties, LF was found to inhibit some autoimmune disorders. In this investigation we studied effects of oral administration of LF on experimental autoimmune encephalomyelitis (EAE) in Lewis rats. LF was given in drinking water as 0.25% solution beginning the day of elicitation of EAE or with a seven-day delay. The effects of LF were evaluated by the following criteria: clinical score, lymph node cell number, serum cytokine levels and histopathological changes. We found that LF treatment led to a significant acceleration of the recovery process, particularly on days 16–18 following elicitation of EAE. The delayed administration of LF was less effective in reducing the score of EAE. In addition, cell number of the inguinal lymph nodes of untreated EAE rats, almost 3 times higher as compared with control, naïve rats, was normalized by LF treatment. Furthermore, LF decreased elevated serum concentrations of tumor necrosis factor alpha and transforming growth factor beta. The histological analysis of the spinal cord revealed reduction in the number and size of inflammatory foci in LF-treated rats. In summary, treatment of EAE Lewis rats with LF reduced the clinical symptoms and accelerated the recovery of animals. |
| doi_str_mv | 10.1016/j.jneuroim.2006.10.008 |
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Beside anti-inflammatory properties, LF was found to inhibit some autoimmune disorders. In this investigation we studied effects of oral administration of LF on experimental autoimmune encephalomyelitis (EAE) in Lewis rats. LF was given in drinking water as 0.25% solution beginning the day of elicitation of EAE or with a seven-day delay. The effects of LF were evaluated by the following criteria: clinical score, lymph node cell number, serum cytokine levels and histopathological changes. We found that LF treatment led to a significant acceleration of the recovery process, particularly on days 16–18 following elicitation of EAE. The delayed administration of LF was less effective in reducing the score of EAE. In addition, cell number of the inguinal lymph nodes of untreated EAE rats, almost 3 times higher as compared with control, naïve rats, was normalized by LF treatment. Furthermore, LF decreased elevated serum concentrations of tumor necrosis factor alpha and transforming growth factor beta. The histological analysis of the spinal cord revealed reduction in the number and size of inflammatory foci in LF-treated rats. In summary, treatment of EAE Lewis rats with LF reduced the clinical symptoms and accelerated the recovery of animals.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2006.10.008</identifier><identifier>PMID: 17113653</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Animals ; Cattle ; Encephalomyelitis, Autoimmune, Experimental - blood ; Encephalomyelitis, Autoimmune, Experimental - pathology ; Encephalomyelitis, Autoimmune, Experimental - physiopathology ; Experimental autoimmune encephalomyelitis (EAE) ; Female ; Groin ; Lactoferrin (LF) ; Lactoferrin - pharmacology ; Lymph Nodes - pathology ; Multiple sclerosis (MS) ; Neurology ; Rats ; Rats, Inbred Lew ; Spinal Cord - pathology ; Transforming Growth Factor beta - blood ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Journal of neuroimmunology, 2007-01, Vol.182 (1), p.160-166</ispartof><rights>Elsevier B.V.</rights><rights>2006 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-e71cef5f9b7ff00a6909845b0314b0f32c766d8b715f4286956e550c9cb902a63</citedby><cites>FETCH-LOGICAL-c518t-e71cef5f9b7ff00a6909845b0314b0f32c766d8b715f4286956e550c9cb902a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2006.10.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17113653$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimecki, Michał</creatorcontrib><creatorcontrib>Kocięba, Maja</creatorcontrib><creatorcontrib>Chodaczek, Grzegorz</creatorcontrib><creatorcontrib>Houszka, Marek</creatorcontrib><creatorcontrib>Kruzel, Marian L</creatorcontrib><title>Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Lactoferrin (LF) is a multifunctional protein present in secretory fluids of mammals and circulating neutrophils. Beside anti-inflammatory properties, LF was found to inhibit some autoimmune disorders. In this investigation we studied effects of oral administration of LF on experimental autoimmune encephalomyelitis (EAE) in Lewis rats. LF was given in drinking water as 0.25% solution beginning the day of elicitation of EAE or with a seven-day delay. The effects of LF were evaluated by the following criteria: clinical score, lymph node cell number, serum cytokine levels and histopathological changes. We found that LF treatment led to a significant acceleration of the recovery process, particularly on days 16–18 following elicitation of EAE. The delayed administration of LF was less effective in reducing the score of EAE. In addition, cell number of the inguinal lymph nodes of untreated EAE rats, almost 3 times higher as compared with control, naïve rats, was normalized by LF treatment. Furthermore, LF decreased elevated serum concentrations of tumor necrosis factor alpha and transforming growth factor beta. The histological analysis of the spinal cord revealed reduction in the number and size of inflammatory foci in LF-treated rats. In summary, treatment of EAE Lewis rats with LF reduced the clinical symptoms and accelerated the recovery of animals.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Cattle</subject><subject>Encephalomyelitis, Autoimmune, Experimental - blood</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - physiopathology</subject><subject>Experimental autoimmune encephalomyelitis (EAE)</subject><subject>Female</subject><subject>Groin</subject><subject>Lactoferrin (LF)</subject><subject>Lactoferrin - pharmacology</subject><subject>Lymph Nodes - pathology</subject><subject>Multiple sclerosis (MS)</subject><subject>Neurology</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Spinal Cord - pathology</subject><subject>Transforming Growth Factor beta - blood</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7uzqX1j65K3HStL56Isoi18woKCeQzpTwbTdnTbpXp1_b5oZEbzsKaF43irqKUJuKewpUPmy3_cTrimGcc8AZCnuAfQjsqNasVo3jD4muwKKWiimr8h1zj0AFbxpn5IrqijlUvAd-XywbokeUwpTZUccQkx2wVzl0zgvccxV9BX-njGFEafFDhVODufvdojjqdBLyFVJHvBX-ZRkfkaeeDtkfH55b8i3d2-_3n2oD5_ef7x7c6idoHqpUVGHXvi2U94DWNlCqxvRAadNB54zp6Q86k5R4RumZSskCgGudV0LzEp-Q16c-84p_lwxL2YM2eEw2Anjmo3UDahG8QdBBkw3jdxAeQZdijkn9GYuS9t0MhTMJt305q90s0nf6kV6Cd5eJqzdiMd_sYvlArw-A1iE3AdMJruweTyGhG4xxxgenvHqvxZuCFNwdviBJ8x9XNNUdBtqMjNgvmyn3y4PEoC3XPI_MdKsPA</recordid><startdate>20070101</startdate><enddate>20070101</enddate><creator>Zimecki, Michał</creator><creator>Kocięba, Maja</creator><creator>Chodaczek, Grzegorz</creator><creator>Houszka, Marek</creator><creator>Kruzel, Marian L</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070101</creationdate><title>Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats</title><author>Zimecki, Michał ; Kocięba, Maja ; Chodaczek, Grzegorz ; Houszka, Marek ; Kruzel, Marian L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c518t-e71cef5f9b7ff00a6909845b0314b0f32c766d8b715f4286956e550c9cb902a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Cattle</topic><topic>Encephalomyelitis, Autoimmune, Experimental - blood</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - physiopathology</topic><topic>Experimental autoimmune encephalomyelitis (EAE)</topic><topic>Female</topic><topic>Groin</topic><topic>Lactoferrin (LF)</topic><topic>Lactoferrin - pharmacology</topic><topic>Lymph Nodes - pathology</topic><topic>Multiple sclerosis (MS)</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Spinal Cord - pathology</topic><topic>Transforming Growth Factor beta - blood</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimecki, Michał</creatorcontrib><creatorcontrib>Kocięba, Maja</creatorcontrib><creatorcontrib>Chodaczek, Grzegorz</creatorcontrib><creatorcontrib>Houszka, Marek</creatorcontrib><creatorcontrib>Kruzel, Marian L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimecki, Michał</au><au>Kocięba, Maja</au><au>Chodaczek, Grzegorz</au><au>Houszka, Marek</au><au>Kruzel, Marian L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2007-01-01</date><risdate>2007</risdate><volume>182</volume><issue>1</issue><spage>160</spage><epage>166</epage><pages>160-166</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Lactoferrin (LF) is a multifunctional protein present in secretory fluids of mammals and circulating neutrophils. Beside anti-inflammatory properties, LF was found to inhibit some autoimmune disorders. In this investigation we studied effects of oral administration of LF on experimental autoimmune encephalomyelitis (EAE) in Lewis rats. LF was given in drinking water as 0.25% solution beginning the day of elicitation of EAE or with a seven-day delay. The effects of LF were evaluated by the following criteria: clinical score, lymph node cell number, serum cytokine levels and histopathological changes. We found that LF treatment led to a significant acceleration of the recovery process, particularly on days 16–18 following elicitation of EAE. The delayed administration of LF was less effective in reducing the score of EAE. In addition, cell number of the inguinal lymph nodes of untreated EAE rats, almost 3 times higher as compared with control, naïve rats, was normalized by LF treatment. Furthermore, LF decreased elevated serum concentrations of tumor necrosis factor alpha and transforming growth factor beta. The histological analysis of the spinal cord revealed reduction in the number and size of inflammatory foci in LF-treated rats. In summary, treatment of EAE Lewis rats with LF reduced the clinical symptoms and accelerated the recovery of animals.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>17113653</pmid><doi>10.1016/j.jneuroim.2006.10.008</doi><tpages>7</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Cattle Encephalomyelitis, Autoimmune, Experimental - blood Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - physiopathology Experimental autoimmune encephalomyelitis (EAE) Female Groin Lactoferrin (LF) Lactoferrin - pharmacology Lymph Nodes - pathology Multiple sclerosis (MS) Neurology Rats Rats, Inbred Lew Spinal Cord - pathology Transforming Growth Factor beta - blood Tumor Necrosis Factor-alpha - blood |
| title | Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats |
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