Attenuation of actinomyosinII contractile activity in growth cones accelerates filopodia-guided and microtubule-based neurite elongation

Abstract The myosinII-specific inhibitor blebbistatin was used to attenuate actinomyosinII contractility in E7-chicken retina explant, medulla and spinal cord neuronal cell cultures. Addition of 20–100 μM blebbistatin, a concentration range that reversibly disrupts actin stress fibers, led to a redu...

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Veröffentlicht in:	Brain research 2007-10, Vol.1176, p.1-10
Hauptverfasser:	Rösner, Harald, Möller, Wolfgang, Wassermann, Torsten, Mihatsch, Julia, Blum, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actomyosin - antagonists & inhibitors Actomyosin - metabolism Amides - pharmacology Animals Biological and medical sciences Blebbistatin Cell structures and functions Central Nervous System - cytology Central Nervous System - embryology Central Nervous System - metabolism Chick Embryo Contractile Proteins - metabolism Cytoskeletal Proteins - metabolism Cytoskeleton, cytoplasm. Intracellular movements Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Fibronectins - metabolism Fibronectins - pharmacology Fundamental and applied biological sciences. Psychology Growth Cones - metabolism Growth Cones - ultrastructure Heterocyclic Compounds, 4 or More Rings - pharmacology Laminin - metabolism Laminin - pharmacology Microtubules Microtubules - metabolism Microtubules - ultrastructure Molecular and cellular biology Myosin Neural Pathways - cytology Neural Pathways - embryology Neural Pathways - metabolism Neurite outgrowth Neurites - metabolism Neurites - ultrastructure Neurogenesis - physiology Neurology Nocodazole - pharmacology Paclitaxel - pharmacology Pseudopodia - metabolism Pseudopodia - ultrastructure Pyridines - pharmacology rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - metabolism Tubulin Modulators - pharmacology
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