Orientational control is an efficient control mechanism for phase switching in the E. coli fim system
The fim system in E. coli controls the expression of type-1 fimbriae. These are hair-like structures that can be used to attach to host cells. Fimbriation is controlled by a mechanism called “orientational control.” We present two families of models for orientational control to understand the detail...
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| Veröffentlicht in: | Journal of theoretical biology 2007-02, Vol.244 (3), p.541-551 |
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| container_title | Journal of theoretical biology |
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| creator | Chu, Dominique Blomfield, Ian C. |
| description | The
fim system in
E. coli controls the expression of type-1 fimbriae. These are hair-like structures that can be used to attach to host cells. Fimbriation is controlled by a mechanism called “orientational control.” We present two families of models for orientational control to understand the details of how it works. We find that the main benefits of orientational control are that (i) it allows rapid adjustment of fimbriation levels in response to a change of environmental conditions while (ii) keeping the overall frequencies with which a cell switches between the fimbriate state and the afimbriate state low. The main reason for the efficiency of orientational control in regulation of fimbriation levels is that it keeps the system far from its steady state. |
| doi_str_mv | 10.1016/j.jtbi.2006.08.016 |
| format | Article |
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fim system in
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| ispartof | Journal of theoretical biology, 2007-02, Vol.244 (3), p.541-551 |
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| subjects | Animals Bacterial Adhesion E. coli Escherichia coli Escherichia coli - physiology Escherichia coli Infections - transmission Fim Fimbriae, Bacterial - physiology Markov Chains Models, Biological Phase variation Steady-state Stochastic Processes |
| title | Orientational control is an efficient control mechanism for phase switching in the E. coli fim system |
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