Filovirus-Like Particles Produced in Insect Cells: Immunogenicity and Protection in Rodents

Background. Virus-like particles (VLPs) of Ebola virus (EBOV) and Marburg virus (MARV) produced in human 293T embryonic kidney cells have been shown to be effective vaccines against filoviral infection. In this study, we explored alternative strategies for production of filovirus-like particle-based...

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Veröffentlicht in:	The Journal of infectious diseases 2007-11, Vol.196 (Supplement-2), p.S421-S429
Hauptverfasser:	Warfield, Kelly L., Posten, Nichole A., Swenson, Dana L., Olinger, Gene G., Esposito, Dominic, Gillette, William K., Hopkins, Ralph F., Costantino, Julie, Panchal, Rekha G., Hartley, James L., Aman, M. Javad, Bavari, Sina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Baculoviridae Baculovirus Cell Line Dendritic Cells - immunology Disease Models, Animal Ebola virus Ebolavirus - immunology Ebolavirus - physiology Female Filoviridae - immunology Filoviridae Infections - immunology Hemorrhagic Fever, Ebola - immunology Humans Insect genetics Insect vectors Insect viruses Kidney cells Marburg virus Marburg Virus Disease - immunology Marburgvirus - immunology Marburgvirus - physiology Mice Mice, Inbred C57BL Prophylaxis and Therapy Rodentia T lymphocytes Vaccination Virus Replication Viruses
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